Results 21 to 30 of about 254,276 (267)

An in vitro stem cell model of human epiblast and yolk sac interaction

eLife, 2021
Human embryogenesis entails complex signalling interactions between embryonic and extra-embryonic cells. However, how extra-embryonic cells direct morphogenesis within the human embryo remains largely unknown due to a lack of relevant stem cell models ...
Kirsty ML Mackinlay, Bailey AT Weatherbee, Viviane Souza Rosa, Charlotte E Handford, George Hudson, Tim Coorens, Lygia V Pereira, Sam Behjati, Ludovic Vallier, Marta N Shahbazi, Magdalena Zernicka-Goetz   +10 more
doaj   +1 more source

Assessment of Egg Yolk IgY Antibodies Against Live or Inactivated Aeromonas hydrophila for Polyvalent Passive Immunization in Goldfish (Carassius auratus)

Fishes
Egg yolk IgY antibody has significant application potential in aquaculture as a form of passive immunotherapy against various bacterial infections owing to its capacity for large-scale and cost-effective production.
Pan Cui, Jing Chen, Huihui Xiao, Xixian Che, Shujun Sun, Zijian Ma, Juan Lu, Gaoxiao Xu, Xiang Liu   +8 more
doaj   +1 more source

Comparison of Genome-Wide DNA Methylation Profiles of Human Fetal Tissues Conceived by in vitro Fertilization and Natural Conception

Frontiers in Cell and Developmental Biology, 2021
BackgroundAssisted reproductive technology (ART) might induce adverse pregnancy outcomes and increase the risk of metabolic diseases in offspring’ later life with unknown reasons.
Ye Liu, Ye Liu, Ye Liu, Xinzhu Li, Xinzhu Li, Xinzhu Li, Songchang Chen, Songchang Chen, Songchang Chen, Li Wang, Li Wang, Yajing Tan, Yajing Tan, Xiaocui Li, Lin Tang, Junyu Zhang, Dandan Wu, Dandan Wu, Yanting Wu, Yanting Wu, Yanting Wu, Xinmei Liu, Xinmei Liu, Xinmei Liu, Yimin Zhu, Jianzhong Sheng, Jianzhong Sheng, Jianzhong Sheng, Jiexue Pan, Jiexue Pan, Jiexue Pan, Li Jin, Li Jin, Li Jin, Hefeng Huang, Hefeng Huang, Hefeng Huang, Hefeng Huang, Hefeng Huang   +38 more
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Evaluation of Immunoprotective Activities of White Button Mushroom (Agaricus bisporus) Water Extract Against Major Pathogenic Bacteria (Aeromonas hydrophila or Vibrio fluvialis) in Goldfish (Carassius auratus)

Animals
The white button mushroom (Agaricus bisporus) is a widely cultivated edible and medicinal mushroom, which contains various active substances, and has application value against pathogenic bacteria in aquaculture. Firstly, A. bisporus water extract (AB-WE)
Shujun Sun, Jing Chen, Pan Cui, Xiaoxiao Yang, Yuhan Zheng, Zijian Ma, Yong Liu, Xiang Liu   +7 more
doaj   +1 more source

Morphogenesis of extra-embryonic tissues directs the remodelling of the mouse embryo at implantation

Nature Communications, 2019
How the shape of the pre-implantation murine embryo changes dramatically upon implantation is unclear. Here, the authors use live imaging with a cdx2-GFP reporter line in combination with loss of function experiments to demonstrate that FGF signalling ...
Neophytos Christodoulou, Antonia Weberling, Douglas Strathdee, Kurt I. Anderson, Paul Timpson, Magdalena Zernicka-Goetz   +5 more
doaj   +1 more source

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

The Passive Immunoprotective Activity Using Egg Yolk IgY Antibodies of Live or Inactivated Aeromonas veronii Against Major Pathogenic Bacteria (A. veronii and A. hydrophila) in Fish

Veterinary Sciences
Egg yolk immunoglobulin Y (IgY) has significant application potential in aquaculture as passive immunotherapy against various bacterial infections owing to its capacity for large-scale and cost-effective production.
Jing Chen, Pan Cui, Huihui Xiao, Xiaoqing Wu, Juan Lu, Yong Liu, Xiang Liu   +6 more
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

BPS causes abnormal blastocyst development by inhibiting cell proliferation

Ecotoxicology and Environmental Safety
In recent years, the escalating global utilization of bisphenol S (BPS) has raised growing concerns regarding its potential adverse effects on human health.
Qing Liu, Ruisong Bai, Xiaoyu Zhang, Siyu Wang, Zhipeng Lin, Yuheng Bi, Qing Ding, Wenya Zhang, Xiaoyun Wu, Shangrong Zhang, Zijian Ma, Hongcheng Wang, Xiaoqing Wu, Yong Liu   +13 more
doaj   +1 more source