Results 61 to 70 of about 7,106,650 (202)

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Effect of endometrial thickness and embryo quality on live-birth rate of fresh IVF/ICSI cycles: a retrospective cohort study

Reproductive Biology and Endocrinology, 2020
Background Successful implantation and delivery require both the functional embryo and receptive endometrium in assisted reproductive technology (ART) cycles. However, little is known about embryo-endometrial interaction on live-birth.
Hong Lv, Xiuzhu Li, Jiangbo Du, Xiufeng Ling, Feiyang Diao, Qun Lu, Shiyao Tao, Lei Huang, Shiyao Chen, Xiumei Han, Kun Zhou, Bo Xu, Xiaoyu Liu, Hongxia Ma, Yankai Xia, Hongbing Shen, Zhibin Hu, Guangfu Jin, Yichun Guan, Xinru Wang   +19 more
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Mitochondrial DNA copy number level in the culture medium of human embryos as a factor in predicting the onset and prolongation of pregnancy

RUDN Journal of Medicine
Relevance. A key factor influencing the effectiveness of assisted reproductive technology programmes is the quality of the embryo transferred into the uterine cavity.
Olga I. Lisitsyna, Nataliya P. Makarova, Aleksey M. Krasnyi, Alexey N. Ekimov, Andrey Yu. Romanov, Nataliya V. Dolgushina   +5 more
doaj   +1 more source

Top‐quality embryo transfer is associated with lower odds of ectopic pregnancy

Acta Obstetricia et Gynecologica Scandinavica, 2022
Introduction The incidence of ectopic pregnancy is up to four times higher after in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) than in spontaneous pregnancies, and the risk of ectopic pregnancy is increased by tubal factor ...
Simona Anzhel, Sirpa Mäkinen, Helena Tinkanen, Tiina Mikkilä, Anni Haltia, Antti Perheentupa, Candido Tomás, Hannu Martikainen, Aila Tiitinen, Juha S. Tapanainen, Zdravka Veleva   +10 more
doaj   +1 more source

Contribution of JAM-1 to epithelial differentiation and tight-junction biogenesis in the mouse preimplantation embryo [PDF]

, 2004
We have investigated the contribution of the tight junction (TJ) transmembrane protein junction-adhesion-molecule 1 (JAM-1) to trophectoderm epithelial differentiation in the mouse embryo.
Fay C. Thomas, Dejana, E., Bhavwanti Sheth, Tom P. Fleming, Fleming, T.P., Sheth, B., Judith J. Eckert, Gianfranco Bazzoni, Elisabetta Dejana, Bazzoni, G., Thomas, F.C., Eckert, J.J.   +11 more
core   +1 more source

Anti-Mullerian hormone: a marker for oocyte quantity, oocyte quality and embryo quality?

, 2008
Serum anti-Mullerian hormone (AMH) concentrations decline with increasing age and constitute a Sensitive marker for ovarian ageing. In addition, basal serum AMH concentrations predict ovarian response during IVF cycles. Concomitantly, oocyte quantity and
Jong, Frank, Visser, Jenny; id_orcid, Lie Fong, Sharon, Schipper, I, Laven, Joop, Baart, Esther; id_orcid, Themmen, Axel, Fauser, BCJM (Bart), Martini, E (Elena)   +8 more
core   +5 more sources

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Concentration of stromal cell‐derived factor‐1 (SDF‐1/CXCL12) in the follicular fluid is associated with blastocyst development

Reproductive Medicine and Biology, 2019
Purpose To study the association between stromal cell‐derived factor‐1 (SDF‐1/CXCL12) and vascular endothelial growth factor (VEGF) concentrations in individual human ovarian follicles and IVF outcomes.
Akemi Nishigaki, Tomoko Tsuzuki‐Nakao, Takeharu Kido, Naoko Kida, Maiko Kakita‐Kobayashi, Hiromi Murata, Hidetaka Okada   +6 more
doaj   +1 more source