Results 221 to 230 of about 143,897 (248)

The tandem–random transition of cellular patterning: proposed roles of N‐cadherin‐based orientational cell adhesions in the development, maintenance, and degeneration of the nucleus pulposus

open access: yesBiological Reviews, EarlyView.
ABSTRACT Intervertebral disc degeneration (IDD) can contribute to lower back and neck pain. In IDD, the most affected component of the intervertebral disc is the nucleus pulposus (NP). Derived from the notochord, where cells are organized into a tandem configuration, young NP cells cluster in three‐dimensional (3D) networks embedded in a gelatinous ...
Xiangyun Wei, Nam Vo, Gwendolyn A. Sowa
wiley   +1 more source

Indirect somatic embryogenesis of <i>Agave maximiliana</i> Baker. [PDF]

open access: yesFront Plant Sci
Delgado-Aceves L   +4 more
europepmc   +1 more source

Integration of epigenetics into ecotoxicology: insights and fundamental research needs

open access: yesBiological Reviews, EarlyView.
ABSTRACT Epigenetics refers to heritable changes in genome function that occur without direct alterations to the DNA sequence. A multitude of environmental contaminants can influence the epigenetic marks of a genome. Changes of epigenetic marks including DNA methylation, histone modifications, and non‐coding RNAs can induce alterations at the gene ...
Albano Pinto   +3 more
wiley   +1 more source

Rational design of induced regeneration via somatic embryogenesis in the absence of exogenous phytohormones. [PDF]

open access: yesPlant Cell
Wittmer J   +15 more
europepmc   +1 more source

Targeting Wnt/β‐Catenin Pathway by DNA Alkylating Pyrrole‐Imidazole Polyamide in Colon Cancer

open access: yesCancer Science, EarlyView.
Wnt/β‐catenin pathway is aberrantly activated in various cancers. We have synthesized a novel DNA alkylating PI polyamide (WNT‐Chb) to target the consensus TCF/LEF‐responsible element. WNT‐Chb downregulated the Wnt‐target genes by inhibiting the recruitment of the β‐catenin/TCF transcription complex and reduced tumor growth in a mouse xenograft tumor ...
Osamu Shimozato   +9 more
wiley   +1 more source

SPT5 regulates Pol II pausing and elongation in different ways at early versus late embryonic stages

open access: yes
Dulja A   +8 more
europepmc   +1 more source

MAP1B Variants Disrupt Neuronal Migration: Insights From Three Novel Families

open access: yesClinical Genetics, EarlyView.
Pathogenic variants in MAP1B have recently emerged as a cause of neurodevelopmental disorders characterized by intellectual disability, epilepsy, and cortical malformations, including periventricular nodular heterotopia (PVNH) and polymicrogyria (PMG).
Jessica Archer   +4 more
wiley   +1 more source

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