Results 41 to 50 of about 195,208 (299)

Murine exposure to gold nanoparticles during early pregnancy promotes abortion by inhibiting ectodermal differentiation

Molecular Medicine, 2018
Background Gold nanoparticles (AuNPs) have been widely studied for biomedical applications, although their safety and potential toxicity in pregnancy remains unknown.
Hui Yang, Libo Du, Guangjun Wu, Zhenyu Wu, Jeffrey A. Keelan   +4 more
doaj   +1 more source

Fetal endocrinology

Indian Journal of Endocrinology and Metabolism, 2013
Successful outcome of pregnancy depends upon genetic, cellular, and hormonal interactions, which lead to implantation, placentation, embryonic, and fetal development, parturition and fetal adaptation to extrauterine life.
Sunil Kumar Kota, Kotni Gayatri, Sruti Jammula, Lalit Kumar Meher, Siva Krishna Kota, S. V. S. Krishna, Kirtikumar D Modi   +6 more
doaj   +1 more source

Insulin-like growth factors in embryonic and fetal growth and skeletal development (Review)

Molecular Medicine Reports, 2014
The insulin-like growth factors (IGF)-I and -II have a predominant role in fetal growth and development. IGFs are involved in the proliferation, differentiation and apoptosis of fetal cells in vitro and the IGF serum concentration has been shown to be ...
G. Agrogiannis, S. Sifakis, E. Patsouris, A. Konstantinidou   +3 more
semanticscholar   +1 more source

Modifications in FLAP's second cytosolic loop influence 5‐LOX interaction, inhibitor binding, and leukotriene formation

FEBS Letters, EarlyView.
The enzyme 5‐lipoxygenase (5‐LOX) catalyzes the first step in the biosynthesis of leukotrienes (LTs) involved in inflammatory pathophysiology. After cellular stimulation, 5‐LOX translocates to the nucleus, interacting with the 5‐LOX‐activating protein (FLAP) to form LTA4 from arachidonic acid (AA).
Erik Romp, Katharina Rataj, Stefanie König, Marcia E. Newcomer, Oliver Werz, Ulrike Garscha   +5 more
wiley   +1 more source

Fetal and obstetrics manifestations of mitochondrial diseases

Journal of Translational Medicine
During embryonic and neonatal development, mitochondria have essential effects on metabolic and energetic regulation, shaping cell fate decisions and leading to significant short- and long-term effects on embryonic and offspring health.
Alessia Adelizzi, Anastasia Giri, Alessia Di Donfrancesco, Simona Boito, Alessandro Prigione, Emanuela Bottani, Valentina Bollati, Valeria Tiranti, Nicola Persico, Dario Brunetti   +9 more
doaj   +1 more source

Molecular conservation of marsupial and eutherian placentation and lactation

eLife, 2017
Eutherians are often mistakenly termed ‘placental mammals’, but marsupials also have a placenta to mediate early embryonic development. Lactation is necessary for both infant and fetal development in eutherians and marsupials, although marsupials have a ...
Michael W Guernsey, Edward B Chuong, Guillaume Cornelis, Marilyn B Renfree, Julie C Baker   +4 more
doaj   +1 more source

The thioredoxin‐like and one glutaredoxin domain are required to rescue the iron‐starvation phenotype of HeLa GLRX3 knock out cells

FEBS Letters, EarlyView.
Glutaredoxin (Grx) 3 proteins contain a thioredoxin domain and one to three class II Grx domains. These proteins play a crucial role in iron homeostasis in eukaryotic cells. In human Grx3, at least one of the two Grx domains, together with the thioredoxin domain, is essential for its function in iron metabolism.
Laura Magdalena Jordt, Manuela Gellert, Finja Zelms, Sander Bekeschus, Christopher Horst Lillig   +4 more
wiley   +1 more source

High-fat diet in pregnant rats and adverse fetal outcome

Upsala Journal of Medical Sciences, 2019
Background: Although pregestational obesity has been associated with increased risk of adverse fetal outcome, the mechanisms behind are not known. We aimed to investigate the influence of the maternal metabolic state on fetal outcome in rats exposed to ...
Parri Wentzel, Ulf J. Eriksson, Emilio Herrera   +2 more
doaj   +1 more source

Stage-specific nutritional management and developmental programming to optimize meat production

Journal of Animal Science and Biotechnology, 2023
Over the past few decades, genetic selection and refined nutritional management have extensively been used to increase the growth rate and lean meat production of livestock.
Liang Zhao, Xiangdong Liu, Noe A Gomez, Yao Gao, Jun Seok Son, Song Ah Chae, Mei-Jun Zhu, Min Du   +7 more
doaj   +1 more source

Crosstalk between gut microbiota and tumor: tumors could cause gut dysbiosis and metabolic imbalance

Molecular Oncology, EarlyView.
In this research, we analyzed the relationship between gut microbiota and tumor. We discovered that both subcutaneous and metastatic tumors would alter the composition and metabolic function of gut microbiota. Meanwhile, fecal microbiota transplantation also indicated the anti‐tumor role of the gut microbiota, revealing the crosstalk between tumor and ...
Siyuan Zhang, Haimei Wen, Ying Chen, Jingya Ning, Di Hu, Yujiao Dong, Chenyu Yao, Bo Yuan, Shuanying Yang   +8 more
wiley   +1 more source