Results 101 to 110 of about 14,262,601 (221)

UTX and UTY Demonstrate Histone Demethylase-Independent Function in Mouse Embryonic Development

open access: yesPLoS Genetics, 2012
UTX (KDM6A) and UTY are homologous X and Y chromosome members of the Histone H3 Lysine 27 (H3K27) demethylase gene family. UTX can demethylate H3K27; however, in vitro assays suggest that human UTY has lost enzymatic activity due to sequence divergence ...
Karl B Shpargel   +3 more
semanticscholar   +1 more source

The role of retinoic acid in embryonic and post-embryonic development [PDF]

open access: yesProceedings of the Nutrition Society, 2000
Retinoic acid (RA) is the bioactive metabolite of vitamin A (retinol) which acts on cells to establish or change the pattern of gene activity. Retinol is converted to RA by the action of two types of enzyme, retinol dehydrogenases and retinal dehydrogenases.
openaire   +2 more sources

Low androgen signaling rescues genome integrity with innate immune response by reducing fertility in humans

open access: yesCell Death and Disease
Development of the gonads under complex androgen regulation is critical for germ cells specification. In this work we addressed the relationship between androgens and genomic integrity determining human fertility.
J. Zimmer   +7 more
doaj   +1 more source

The 4D Human Embryonic Brain Atlas: spatiotemporal atlas generation for rapid anatomical changes using first-trimester ultrasound from the Rotterdam Periconceptional Cohort [PDF]

open access: yesarXiv
Early brain development is crucial for lifelong neurodevelopmental health. However, current clinical practice offers limited knowledge of normal embryonic brain anatomy on ultrasound, despite the brain undergoing rapid changes within the time-span of days.
arxiv  

Predictive computation of genomic logic processing functions in embryonic development

open access: yesProceedings of the National Academy of Sciences of the United States of America, 2012
Gene regulatory networks (GRNs) control the dynamic spatial patterns of regulatory gene expression in development. Thus, in principle, GRN models may provide system-level, causal explanations of developmental process.
Isabelle S. Peter, E. Faure, E. Davidson
semanticscholar   +1 more source

Reversine inhibits proliferation and induces apoptosis of human osteosarcoma cells through targeting MEK1

open access: yesJournal of Bone Oncology
Reversine, or 2-(4-morpholinoanilino)-6-cyclohexylaminopurine, is a 2,6-disubstituted purine derivative. This small molecule shows anti-tumor potential by playing a central role in the inhibition of several kinases related to cell cycle regulation and ...
Xianlong Chen   +6 more
doaj  

Importance of the pluripotency factor LIN28 in the mammalian nucleolus during early embryonic development

open access: yesDevelopment, 2012
The maternal nucleolus is required for proper activation of the embryonic genome (EGA) and early embryonic development. Nucleologenesis is characterized by the transformation of a nucleolar precursor body (NPB) to a mature nucleolus during ...
Edgar-John Vogt   +4 more
semanticscholar   +1 more source

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