Results 111 to 120 of about 537,037 (306)

In vivo and in vitro therapeutic evaluation of bone marrow-derived mesenchymal stem cells in liver cancer treatment

Frontiers in Cell and Developmental Biology
Hepatocellular carcinoma is the seventh most common kind of cancer worldwide and the second largest cause of cancer-related deaths in males, behind lung cancer.
Abdulrahman Johor, Abdulrahman Johor, A. S. M. Mahadiuzzaman, A. S. M. Mahadiuzzaman, Abdulaziz Abdullah Alqusayer, Abdulaziz Abdullah Alqusayer, Saleh Abdulaziz Alkarim, Saleh Abdulaziz Alkarim, Saleh Abdulaziz Alkarim, F. A. Dain Md Opo, F. A. Dain Md Opo   +10 more
doaj   +1 more source

Advanced 3D Platforms for Modeling CNS Neuroinflammation: Cell Integration, Techniques, and Challenges

Advanced Healthcare Materials, EarlyView.
This review summarizes the roles of key central nervous system cell types, the extracellular matrix, and the blood‐brain barrier in neuroinflammation, and their integration into diverse 3D culture systems. It examines major incorporation strategies, including direct co‐culture, hydrogel encapsulation, transwell migration assays, and bioprinting ...
Emmanuelle D. Aiyegbusi, Julia Di Stefano, Dearbhaile Dooley   +2 more
wiley   +1 more source

Establishment and application of a prediction model for blastocyst formation rate and delivery outcome in human assisted reproductive technology

Reproduction and Fertility
With the gradual emergence of population issues and the increasing incidence of infertility, the role of assisted reproductive technology (ART) is becoming increasingly important.
Meng-Dan Xi, Hong-Yi Xu, Xiao-Ning Wang, Jia-Rong Tian, Min Lu, Hong-Tao Zheng, Li He, Ying Zhang   +7 more
doaj   +1 more source

The Presence of Stem Cells in Human Breast Milk and Research Implications [PDF]

, 2016
Stem cell therapy research is an expanding area of study as stem cell therapy is believed to have the potential to provide treatment options for numerous disease processes.
Peterson, Melody (Brooke)
core  

Dynamic Modulation of the Microenvironment Promotes Functional Maturation of Engineered Tissues

Advanced Healthcare Materials, EarlyView.
Engineered tissues lack the dynamic microenvironment of native tissues. A biocompatible, diffusible small molecule to dynamically modulate tissue microenvironments during maturation is used. Timing‐dependent modulation yields distinct outcomes, producing thicker, more native‐like blood vessels, stronger and more mature cardiac tissues, and optimized ...
Eric Silberman, Hadas Oved, Itay Gil, Amgad Marzook, Ester Sapir Baruch, Yahel Shechter, Assaf Shapira, Tal Dvir   +7 more
wiley   +1 more source

Constraints to Progress in Embryonic Stem Cells from Domestic Species [PDF]

, 2013
Domestic animal embryonic stem cells are of potentially big value in transgenic research and studies of lineage commitment and development. Unfortunately, despite many efforts, validated embryonic stem cell lines in species other than mice and primates ...
Caamaño, J.N. (José), Díez, C., Gómez, E., Molina, I., Muñoz, M., Trigal, B.   +5 more
core  

Small Extracellular Vesicles from Neural Cells: Physiological and Pathological Roles, and Potential in Neurodegenerative Therapy

Advanced Healthcare Materials, EarlyView.
Neural cell–derived small extracellular vesicles (sEVs) are emerging as pivotal mediators in neurodegenerative diseases, exerting both pathogenic and therapeutic functions. This review synthesizes current evidence on how sEVs from distinct neural cell types regulate neurodegeneration, neuroprotection, biomarker discovery, and targeted drug delivery ...
Muhammad Waqas Salim, Wei Zhang, Lyndsey Collins‐Praino, Yuling Wang, Andrew Care   +4 more
wiley   +1 more source

Three‐Dimensional Ovary Model to Improve and Study Murine Follicle Growth

Advanced Healthcare Materials, EarlyView.
To develop new methods for fertility preservation in women, novel culture systems for small follicles need to be established. In this work, a poly(ethylene glycol) based scaffold, with appropriate mechanical and bioactive features to support mouse follicle and ovary cell growth is developed, and the formed cell‐follicle interactions are visualized ...
Mira Jacobs, Valon Gllareva, Lukas Moser, Silvia Pravato, Eric Mora Pimentel, Brigitte Leeners, Martin Ehrbar   +6 more
wiley   +1 more source

ETV2 Mediated Differentiation of Human Pluripotent Stem Cells Results in Functional Endothelial Cells for Engineering Advanced Vascularized Microphysiological Models

Advanced Healthcare Materials, EarlyView.
A robust method to generate functional human iPSC‐derived endothelial cells using inducible ETV2 expression. These cells self‐organize into stable, lumenized microvascular networks within microfluidic chips, surpassing conventional differentiation methods.
Shun Zhang, Zhengpeng Wan, Lei Wang, Caihong Wu, Junkai Zhang, Sarah Spitz, Xun Wang, Marie A. Floryan, Mark F. Coughlin, Francesca M. Pramotton, Liling Xu, Ron Weiss, Roger D. Kamm   +12 more
wiley   +1 more source

A Modular Bioinstructive Platform Reveals Mechanistic Insights into Additive‐Free, Topography‐Driven Osteogenesis

Advanced Healthcare Materials, EarlyView.
Engineered microparticle topographies direct human mesenchymal stem cell osteogenesis without biochemical additives. This osteogenic commitment is driven by canonical Hedgehog signaling and followed by temporal IGF‐II engagement. Two‐photon polymerization demonstrates spatial control, enabling the engineering of topographical gradients that pattern ...
Fatmah I. Ghuloum, Leo A. H. Zeef, Lee A. Stevens, Marco A. N. Domingos, Susan J. Kimber, Mahetab H. Amer   +5 more
wiley   +1 more source