Results 151 to 160 of about 1,293,017 (382)

Saikogenin A improves ethanol-induced liver injury by targeting SIRT1 to modulate lipid metabolism

Communications Biology
Chronic alcohol consumption can lead to alcohol live disease (ALD). Steatosis is a critical hallmark of ALD, making it an important stage for therapeutic intervention.
Mingzhu Jiang, Ying Feng, Jingxian Wang, Xiang Xu, Zegan Liu, Tongfei Li, Shinan Ma, Yufeng Wang, Xingrong Guo, Shiming Du   +9 more
doaj   +1 more source

The ground state of embryonic stem cell self-renewal

Nature, 2008
Qi-Long Ying, Jason P. Wray, J. Nichols, L. Batlle-Morera, B. Doble, J. Woodgett, P. Cohen, Austin G Smith   +7 more
semanticscholar   +1 more source

Emerging Therapeutic Strategies for Hearing Loss

Advanced Therapeutics, EarlyView.
Challenges still exist in treating hearing loss in cases of severe damage to hair cells or spiral ganglion neurons. Here, a schematic diagram of cochlear sensory hair cells and auditory nerves is presented. It is found that in normal Corti organs, hair cells have upright stereocilia at the top and auditory neurons at the base. Ototoxic drugs, noise, or
Shanying Han, Tian Shen, Weiwei He, Hao Wei, Xiaolong Zhao, Wen Yang, Chuan Bu, Xinghua Tang, Yu Zhao, Jiangang Fan   +9 more
wiley   +1 more source

Droplet Barcoding for Single-Cell Transcriptomics Applied to Embryonic Stem Cells

Cell, 2015
Allon M. Klein, L. Mazutis, Ilke Akartuna, Naren P. Tallapragada, A. Veres, V. Li, L. Peshkin, D. Weitz, M. Kirschner   +8 more
semanticscholar   +1 more source

The CRL7FBXW8 Complex Controls the Mammary Stem Cell Compartment through Regulation of NUMB Levels

Advanced Science, EarlyView.
In breast cancer (BC), NUMB loss of function (LOF) is common and mainly driven by protein hyper‐degradation. The CRL7FBXW8 complex is the E3 ligase responsible for NUMB degradation. Inhibition of CRL7FBXW8 in NUMB‐LOF BC cells restores NUMB levels, and decreases the number of cancer stem cells and tumorigenic ability in vivo. Targeting CRL7FBXW8 offers
Simone Sabbioni, Maria Grazia Filippone, Letizia Amadori, Stefano Confalonieri, Roberta Bonfanti, Stefano Capoano, Ivan Nicola Colaluca, Stefano Freddi, Giovanni Bertalot, Giovanni Fagà, Elisa Zagarrí, Mario Varasi, Rosalind Helen Gunby, Ciro Mercurio, Salvatore Pece, Pier Paolo Di Fiore, Daniela Tosoni   +16 more
wiley   +1 more source

The Presence of Stem Cells in Human Breast Milk and Research Implications [PDF]

, 2016
Stem cell therapy research is an expanding area of study as stem cell therapy is believed to have the potential to provide treatment options for numerous disease processes.
Peterson, Melody (Brooke)
core  

The Role and Fate of DNA Ends for Homologous Recombination in Embryonic Stem Cells [PDF]

, 1992
Paul Hasty, Jaime A. Rivera‐Pérez, Allan Bradley   +2 more
openalex   +1 more source

An embryonic stem cell–like gene expression signature in poorly differentiated aggressive human tumors

Nature Genetics, 2008
I. Ben-Porath, Matthew Thomson, V. Carey, Ruping Ge, G. Bell, A. Regev, R. Weinberg   +6 more
semanticscholar   +1 more source

Advances in Microfluidic Cochlea‐On‐A‐Chip

Advanced Science, EarlyView.
This review systematically examines diverse cell sources for inner ear organoids and outlines stepwise induction protocols. Furthermore, it discusses current applications and prospective developments of cochlea‐on‐a‐chip technologies in areas such as deafness modeling, mechanistic studies, and drug evaluation, with particular focus on gene‐therapy drug
Tian Shen, Shanying Han, Weiwei He, Wen Yang, Xinghua Tang, Xiaolong Zhao, Xinghong Liu, Zhenhua Shao, Lin Cheng, Yu Zhao, Jiangang Fan   +10 more
wiley   +1 more source

A DNA signal from the Thy-1 gene defines de novo methylation patterns in embryonic stem cells. [PDF]

, 1990
Moshe Szyf, G Tanigawa, Philip L. McCarthy   +2 more
openalex   +1 more source