Results 151 to 160 of about 848,551 (267)

Polycomb repressive complex PRC1 spatially constrains the mouse embryonic stem cell genome

Nature Genetics, 2015
S. Schoenfelder, R. Sugar, Andrew Dimond, B. Javierre, Harry Armstrong, Borbála Mifsud, Emilia Dimitrova, Louise S. Matheson, Filipe Tavares-Cadete, M. Furlan-Magaril, A. Segonds-Pichon, W. Jurkowski, S. Wingett, Kristina Tabbada, Simon Andrews, Bram Herman, E. Leproust, Cameron S. Osborne, H. Koseki, P. Fraser, N. Luscombe, Sarah Elderkin   +21 more
semanticscholar   +1 more source

Excessive DNA Double‐Strand Breaks–Associated 3D Genome Reorganization Contributes to Neural Tube Defects with Folate Deficiency

Advanced Science, EarlyView.
Neural tube defects (NTDs) are among the most common congenital malformations. However, the underlying etiology and mechanism remain elusive. Here, the role of DNA double‐strand breaks (DSBs) in 3D genome organization within the NTDs with folate deficiency is reported.
Ting Zhang, Lin Lin, Jianting Li, Caihua Li, Shengjun Liang, Xuemei Bai, Fang Wang, Yihua Bao, Dan Guo, Xiaochen Bo, Hao Li, Hebing Chen, Qiu Xie   +12 more
wiley   +1 more source

Selective Ablation of Cochlear Hair Cells Promotes Engraftment of Human Embryonic Stem Cells-derived Progenitors in The Mouse organ of Corti [PDF]

, 2020
Hiroki Takeda, Anna Dondzillo, Jessica A. Randall, Samuel P. Gubbels   +3 more
openalex   +1 more source

Human embryonic stem cell-derived cardiac progenitors for severe heart failure treatment: first clinical case report.

European Heart Journal, 2015
P. Menasché, V. Vanneaux, A. Hagège, A. Bel, B. Cholley, Isabelle Cacciapuoti, Alexandre Parouchev, N. Benhamouda, G. Tachdjian, L. Tosca, J. Trouvin, J. Fabréguettes, V. Bellamy, R. Guillemain, C. Suberbielle Boissel, E. Tartour, M. Desnos, J. Larghero   +17 more
semanticscholar   +1 more source

Integrin α8‐Mediated Pericyte Morphogenesis Controls Blood‐Brain Barrier Integrity

Advanced Science, EarlyView.
This study highlights that ITGA8 impacts pericyte morphology and function, both crucial for BBB integrity, via RhoA/ROCK signaling, thus influencing TGF‐β1 activation through cytoskeletal tension and ECM interactions. Notably, in post‐ischemic recovery models, ITGA8 deficiency exacerbates vascular dysfunction by impairing pericyte‐mediated BBB ...
Chang‐Xiong Gong, Lin‐Lin Hu, Ling Jiang, Pei‐Xia Shi, Shuang Zhang, Yuan Zhao, Bing‐Qiao Wang, Xiao‐Feng Cheng, Cheng‐Kang He, Sen Lin, Yue Dai, Zhao‐You Meng, Chen‐Hao Zhao, Bao‐Liang Sun, Qi Xie, Fang‐Fei Li, Qing‐Wu Yang   +16 more
wiley   +1 more source

In vitro culture of chicken embryonic stem cell-like cells

, 2014
Bo Ram Lee, Hyeon Yang
openalex   +2 more sources

Exploring Functionally Enhanced BLP‐Trained Macrophage Subpopulations in S. Aureus Infection: Underlying Mechanisms and Therapeutic Significance

Advanced Science, EarlyView.
BLP‐trained macrophages show augmented resistance to infection, but their mechanisms remain unclear. scRNA‐seq identified 13 BMDM subsets, with two novel anti‐inflammatory/antibacterial subpopulations (C5/C7) emerging post‐BLP training. BLP training activates NRF2, attenuates oxidative stress/ferroptosis, and boosts glycolysis/OXPHOS. Adoptive transfer
Yantong Wan, Yinghao Hong, Xiangjun Ji, Jing Xiang, Jinxi Liu, Lixin Liang, Meng Ren, Wenhan Chen, Tengfei Xu, Zhijie Li, Tieliu Shi, Yong Jiang, Huaping Liang, Jinghua Liu   +13 more
wiley   +1 more source

Effects of C-Reactive Protein on the Cardiac Differentiation of Mouse Embryonic Stem Cells

, 2015
Yan Jin, Jianing Cao, Xin Xu, Xinhe Ye, Ying Chen, Jun Yang, Qiuting Feng, Li Zhu, Qian Xi, Chengjian Yang   +9 more
openalex   +2 more sources

Lnc‐HZ05 Suppresses Trophoblast Cell Migrasome Formation by Disrupting TGFβ2 Pathway in Unexplained Recurrent Miscarriage

Advanced Science, EarlyView.
TGFβ2 signaling‐mediated migration/invasion and migrasome formation are suppressed in recurrent miscarriage (RM) versus healthy control villous tissues and are negatively associated with unexplained RM. In mechanism, TGFβ2 promotes trophoblast cell migration/invasion and migrasome formation, all of which are suppressed by lnc‐HZ05. In details, lnc‐HZ05
Weina Chen, Ying Zhang, Zimeng Zhao, Yang Yang, Geng Guo, Yi Sun, Tao Zhang, Zhihong Zhang, Liqin Zeng, Wenxin Huang, Qingjun Shen, Ruining Han, Zhaohui He, Depeng Zhao, Huidong Zhang   +14 more
wiley   +1 more source

Characterization and multilineage differentiation of embryonic stem cells derived from a buffalo parthenogenetic embryo [PDF]

, 2007
Hathaitip Sritanaudomchai, K. Pavasuthipaisit, Yindee Kitiyanant, Piengchai Kupradinun, Shoukhrat Mitalipov, Thanit Kusamran   +5 more
openalex   +1 more source