Results 161 to 170 of about 1,123,946 (363)

Dynamics of Cell Fate Decisions during Chemically Induced Multi‐Lineage Trans‐Differentiation at Single‐Cell Level

Advanced Science, EarlyView.
A critical aspect of chromosomal remodeling in small molecule‐induced multilineage trans‐differentiation(iMT) is elucidated. A dynamic atlas spanning over 35 days profiles terminal trans‐differentiated cells, which reverted to a more youthful state. This study reveals parallels between iMT and other cell fate determination processes, emphasizing an ...
Weigao E, Lijiang Fei, Jingjing Wang, Xinru Wang, Renying Wang, Xueyi Wang, Peijing Zhang, Jianhui Chen, Junqing Wu, Mengmeng Jiang, Daosheng Huang, Danmei Jia, Guoji Guo, Xiaoping Han   +13 more
wiley   +1 more source

B-Myb deficiency boosts bortezomib-induced immunogenic cell death in colorectal cancer

Scientific Reports
B-Myb has received considerable attention for its critical tumorigenic function of supporting DNA repair. However, its modulatory effects on chemotherapy and immunotherapy have rarely been reported in colorectal cancer.
Yuan-Jian Hui, Ting-Ting Yu, Liu-Gen Li, Xing-Chun Peng, Mao-Jun Di, Hui Liu, Wen-Long Gu, Tong-Fei Li, Kai-Liang Zhao, Wei-Xing Wang   +9 more
doaj   +1 more source

Blood island formation in attached cultures of murine embryonic stem cells [PDF]

, 1996
Victoria L. Bautch, William L. Stanford, Rebecca Rapoport, Scott D. Russell, Robert S. Byrum, Tracy A. Futch   +5 more
openalex   +1 more source

Self-assembly of embryonic and two extra-embryonic stem cell types into gastrulating embryo-like structures

Nature Cell Biology, 2018
B. Sozen, G. Amadei, A. Cox, Ran Wang, Ellen Na, S. Czukiewska, L. Chappell, T. Voet, Geert Michel, N. Jing, D. Glover, M. Zernicka-Goetz   +11 more
semanticscholar   +1 more source

Nanotherapy for Neural Retinal Regeneration

Advanced Science, EarlyView.
Nanotechnology enhances ophthalmic treatments by improving drug delivery and regenerating ocular tissues, combating vision loss from retinal diseases through innovative nano‐systems. This review outlines ocular anatomy, pathology, immune microenvironment, and barriers, detailing nanocarrier characteristics, classification, and preparation methods, and ...
Chuyao Yu, Li Dong, Yujia Lv, Xuhan Shi, Ruiheng Zhang, Wenda Zhou, Haotian Wu, Heyan Li, Yitong Li, Zhou Li, Dan Luo, Wen‐Bin Wei   +11 more
wiley   +1 more source

Triclosan induces pyroptosis by activation of the caspase-9/3/gasdermin E axis

Emerging Contaminants
The high concentrations of TCS in personal care products, and the potential for even greater exposure in occupational settings, raise significant concerns about its cytotoxic effects.
Shiqi Wu, Lei You, Shan He, Wenqaing Liu, Jinlin Lei, Jiahui Yang, Xiangyin Luo, Zhenxiu Ye, Yonghong Zhang, Jing Wang, Huailan Guo, Yan Zheng, Lanlan Zheng, Chen Li   +13 more
doaj  

High-dimensional Array Bayesian Screening Based on Distributions with Structural Zeroes [PDF]

arXiv
In many biomedical applications with high-dimensional features, such as single-cell RNA-sequencing, it is not uncommon to observe numerous structural zeros. Identifying important features from a pool of high-dimensional data for subsequent detailed analysis is often of interest.
arxiv  

Testing an “In-Out” Targeting Procedure for Making Subtle Genomic Modifications in Mouse Embryonic Stem Cells

, 1991
Vicky Valancius, Oliver Smithies
openalex   +2 more sources

Osteosarcoma Cell‐Derived Migrasomes Promote Macrophage M2 Polarization to Aggravate Osteosarcoma Proliferation and Metastasis

Advanced Science, EarlyView.
Migrasomes are newly discovered organelles in migrating cells. This study finds that osteosarcoma cell‐derived migrasomes promote the tumor‐promoting phenotype of macrophages and further aggravate osteosarcoma malignant progression via milk fat globule‐EGF factor 8.
Wanshun Liu, Lei Li, Xiaoming Bai, Mengxue Zhang, Wei Lv, Yongbin Ma, Yuzhi Sun, Hongjing Zhang, Qing Jiang, Qingqiang Yao, Zhi‐Yuan Zhang   +10 more
wiley   +1 more source

lncRNA FGD5-AS1 is required for gastric cancer proliferation by inhibiting cell senescence and ROS production via stabilizing YBX1

Journal of Experimental & Clinical Cancer Research
Background The vast majority of lncRNAs have low expression abundance, which greatly limits their functional range and impact. As a high expression abundance lncRNA, FGD5-AS1’s non-ceRNA biological function in cancer is unclear.
Shanshan Qin, Yue Liu, Xiangang Zhang, Pan Huang, Lingyun Xia, Weidong Leng, Dandan Li   +6 more
doaj   +1 more source