Results 181 to 190 of about 1,293,017 (382)

The Reconstruction of Peripheral Auditory Circuit: Recent Advances and Future Challenges

Advanced Science, EarlyView.
This paper summarizes the potential of biomaterials, stem cells, and gene editing technologies in the regeneration of inner ear hair cells, spiral ganglion neurons, and inner ear organoids. Challenges and potential developments are discussed and explored.
Zhe Li, Ying Zhang, Zhenyu Xiao, Jieyu Qi   +3 more
wiley   +1 more source

Essential role of STAT3 for embryonic stem cell pluripotency [PDF]

, 1999
Regina Raz, Chien‐Kuo Lee, Linda A. Cannizzaro, Peter D’Eustachio, David E. Levy   +4 more
openalex   +1 more source

Accurate Transcription Factor Activity Inference to Decipher Cell Identity from Single‐Cell Transcriptomic Data with MetaTF

Advanced Science, EarlyView.
MetaTF is a new computational framework that uses single‐cell RNA sequencing (scRNA‐seq) data to infer transcription factor activity with the aim to help in deciphering cells identity starting from a heterogeneous population, and apply it to characterize mouse hematopoietic stem cells and breast cancer epithelial cells, thus identifying a novel subset ...
Yongfei Hu, Yuanyuan Zhu, Guangjue Tang, Ming Shan, Puwen Tan, Ying Yi, Xiyuan Zhang, Man Liu, Xinyu Li, Le Wu, Jia Chen, Hailong Zheng, Yan Huang, Zhuan Li, Xiaobo Li, Dong Wang   +15 more
wiley   +1 more source

In vitro differentiation of embryonic stem cells into lymphocyte precursors able to generate T and B lymphocytes in vivo.

, 1992
José Carlos Gutierrez‐Ramos, Ronald Palacios   +1 more
openalex   +1 more source

DNA‐PKcs‐Driven YAP1 Phosphorylation and Nuclear Translocation: a Key Regulator of Ferroptosis in Hyperglycemia‐Induced Cardiac Dysfunction in Type 1 Diabetes

Advanced Science, EarlyView.
In the context of chronic hyperglycemia, a DDR is initiated, leading to the pathological activation of DNA‐PKcs in the diabetic heart. This activated DNA‐PKcs directly interacts with and phosphorylates YAP1 at Thr226, thereby increasing the nuclear expression of YAP1.
Junyan Wang, Xing Chang, Chun Li, Jing Gao, Zhijiang Guo, Haowen Zhuang, Lingjun Wang, Yusheng Huang, Wei Wang, Chao Li, Qingyong He   +10 more
wiley   +1 more source

Triclosan induces pyroptosis by activation of the caspase-9/3/gasdermin E axis

Emerging Contaminants
The high concentrations of TCS in personal care products, and the potential for even greater exposure in occupational settings, raise significant concerns about its cytotoxic effects.
Shiqi Wu, Lei You, Shan He, Wenqaing Liu, Jinlin Lei, Jiahui Yang, Xiangyin Luo, Zhenxiu Ye, Yonghong Zhang, Jing Wang, Huailan Guo, Yan Zheng, Lanlan Zheng, Chen Li   +13 more
doaj  

B-Myb deficiency boosts bortezomib-induced immunogenic cell death in colorectal cancer

Scientific Reports
B-Myb has received considerable attention for its critical tumorigenic function of supporting DNA repair. However, its modulatory effects on chemotherapy and immunotherapy have rarely been reported in colorectal cancer.
Yuan-Jian Hui, Ting-Ting Yu, Liu-Gen Li, Xing-Chun Peng, Mao-Jun Di, Hui Liu, Wen-Long Gu, Tong-Fei Li, Kai-Liang Zhao, Wei-Xing Wang   +9 more
doaj   +1 more source

Introduction of specific point mutations into RNA polymerase II by gene targeting in mouse embryonic stem cells: evidence for a DNA mismatch repair mechanism.

, 1990
C M Steeg, James Ellis, A Bernstein
openalex   +1 more source

Histone Lactylation Antagonizes Senescence and Skeletal Muscle Aging by Modulating Aging‐Related Pathways

Advanced Science, EarlyView.
This study reveals histone lactylation as a metabolic‐epigenetic regulator countering cellular senescence and skeletal muscle aging. Reduced lactylation impairs cell cycle, DNA repair and proteostasis pathways, while exercise restores glycolytic activity and lactylation levels, preserving muscle function.
Fanju Meng, Jianuo He, Xuebin Zhang, Wencong Lyu, Ran Wei, Shiyi Wang, Zhehao Du, Haochen Wang, Jinlong Bi, Xueyang Hua, Chao Zhang, Yiting Guan, Guoliang Lyu, Xiao‐Li Tian, Lijun Zhang, Wenbing Xie, Wei Tao   +16 more
wiley   +1 more source

A new mouse embryonic stem cell line with good germ line contribution and gene targeting frequency

, 1992
Thomas M. Magin, Jim McWhir, David W. Melton   +2 more
openalex   +1 more source