Results 191 to 200 of about 1,383,394 (337)

Induction of Pluripotent Stem Cells from Mouse Embryonic and Adult Fibroblast Cultures by Defined Factors

Cell, 2006
Kazutoshi Takahashi, S. Yamanaka
semanticscholar   +1 more source

Cryopreserved Human Otic Neuronal Spheroids Self‐assemble for Functional Connectivity Analysis and Long‐term Ototoxicity Evaluation

Advanced Science, EarlyView.
This study establishes a robust and reproducible protocol for generating human otic neuronal spheroids (hONS) from cryopreserved hPSC‐derived pre‐placodal ectoderm cells. These hONS further differentiate into functional SGN‐like neurons, which extend neurite projections toward both murine hair cells and human cortical organoids, thereby forming ...
Gaoying Sun, Yukai Wang, Man Wang, Xinyue Wang, Mingming Tang, Da Li, Jianhuan Qi, Xue Wang, Shujuan Sun, Lei Chen, Weibin An, Ligang Kong, Anqi Suo, Haibo Wang, Wenwen Liu, Lei Xu   +15 more
wiley   +1 more source

The role of METTL3 in transposable elements regulation and 2C-like program induction in mouse embryonic stem cell. [PDF]

Cell Regen
Chen X, Chen B, Zhao Y, Wen Z, Hao J, Jin L, Li D, Quan X, Wu K, Deng M, Bao X, Wang J, Chen J.   +12 more
europepmc   +1 more source

Derivation and characterization of new Chinese human embryonic stem cell lines with normal and abnormal karyotypes [PDF]

, 2008
Xiaofang Sun, Yifei Yin, Yonghua Jiang, Xiaolin Long, Hongzi Du, Wenhong Zhang, Xinjie Chen, Weihua Wang, Guohong Xiao   +8 more
openalex   +1 more source

Complete Meiosis from Embryonic Stem Cell-Derived Germ Cells In Vitro.

Cell Stem Cell, 2016
Quan Zhou, Mei Wang, Yan Yuan, Xuepeng Wang, Rui Fu, Haifeng Wan, Mingming Xie, Mingxi Liu, Xuejiang Guo, Ying Zheng, Guihai Feng, Qinghua Shi, Xiao-Yang Zhao, J. Sha, Qi Zhou   +14 more
semanticscholar   +1 more source

Plant Virus‐Induced Inheritable Apoptosis Drives Reproductive Costs in Female Insect Vectors to Balance Viral Biparental Transmission

Advanced Science, EarlyView.
Rice gall dwarf virus (RGDV), transmitted biparentally by leafhopper vector to their offspring, exploits the capsid protein to induce inheritable ovarian apoptosis via insulin‐driven PI3K/AKT/FoxO signaling axis. This mechanism enhances infection but reduces female reproductive fitness, causing inefficient maternal transmission.
Haibo Wu, Wenqiang Wan, Qingquan Liang, Hengsong Yang, Chengcong Lu, Taiyun Wei, Qian Chen   +6 more
wiley   +1 more source

Generation of implant-type tissue-engineered cartilage from human embryonic stem cell-derived chondrocytes. [PDF]

Regen Ther
Huang YC, Komura H, Ismael AC, Asawa Y, Chen J, Kawasaki T, Enosawa S, Akutsu H, Fuchimoto Y, Hoshi K, Umezawa A, Komura M.   +11 more
europepmc   +1 more source

Contacting co-culture of human retinal microvascular endothelial cells alters barrier function of human embryonic stem cell derived retinal pigment epithelial cells

, 2017
Heli Skottman, Jussi Muranen, Helena Lähdekorpi, Elina Pajula, Katja Mäkelä, Laura Koivusalo, Arto Koistinen, Hannu Uusitalo, Kai Kaarniranta, Kati Juuti‐Uusitalo   +9 more
openalex   +1 more source

Hyperandrogenemia Induces Trophoblast Ferroptosis and Early Pregnancy Loss in Patients With PCOS via CMA‐Dependent FTH1 Degradation

Advanced Science, EarlyView.
In PCOS patients with hyperandrogenemia, decreased ferritin heavy chain 1 (FTH1) causes Fe2⁺ overload and ferroptosis in trophoblasts. Androgens induce FTH1 protein degradation via AR‐LAMP2A‐mediated chaperone‐mediated autophagy pathway, leading to placental development disruption and early pregnancy loss. Metformin mitigates androgen‐induced placental
Hanjing Zhou, Weijie Yang, Na Liu, Qing Liu, Jiamin Jin, Chenqiong Zhao, Xiaoying Jin, Miao Gui, Haiyan Zhu, Songying Zhang, Yinli Zhang   +10 more
wiley   +1 more source

Embryonic stem cell-derived extracellular vesicles delay cellular senescence by inhibiting oxidative stress. [PDF]

J Biol Chem
Enomoto S, Hur YH, Solodova T, Neumann J, Cerione RA, Antonyak MA.   +5 more
europepmc   +1 more source