Results 261 to 270 of about 1,293,017 (382)

Development of Endothelial Cell Lines From Embryonic Stem Cells [PDF]

, 2000
Giovanna Balconi, Raffaella Spagnuolo, Elisabetta Dejana   +2 more
openalex   +1 more source

PRMT5 Inhibitor Synergizes with Chemotherapy to Induce Resembling Mismatch Repair Deficiency and Enhance Anti‐TIGIT Therapy in Microsatellite‐Stable Colorectal Cancer

Advanced Science, EarlyView.
Microsatellite‐stable (MSS) colorectal cancer (CRC) resists immunotherapy. PRMT5 inhibition enhances CPT‐11 sensitivity, inducing a PMS2‐deficient‐like state and cytosolic dsDNA release, which activates the cGAS‐STING pathway to promote anti‐tumor immunity. However, this combination therapy upregulates TIGIT expression on CD8+ T cells, and the addition
Jiang Zhu, Shenao Fu, Xi Zou, Hanjiang Zeng, Guangzu Cui, Yinghui Peng, Diya Tang, Fan Zhang, Hong Shen, Shan Zeng, Ying Han   +10 more
wiley   +1 more source

Correction: CRISPR/Cas9-mediated activation of NR5A1 steers female human embryonic stem cell-derived bipotential gonadal-like cells towards a steroidogenic cell fate. [PDF]

J Ovarian Res
Danti L, Lundin K, Sepponen K, Yohannes DA, Kere J, Tuuri T, Tapanainen JS.   +6 more
europepmc   +1 more source

Engineered Genetic Circuits Activated by Bezafibrate Improve ESC‐Based TAA Cancer Vaccine Efficacy and PD‐L1 Nanobody Therapy

Advanced Science, EarlyView.
Synthetic gene circuits regulated by bezafibrate are developed to express tumor antigens and PD‐L1 nanobody (PD‐L1nb), enhancing cancer immunotherapy. Delivered via HEK293T cells, ESCs, or directly injected the plasmids containing the circuit into the tumor, the circuits reduce tumor growth, boost CD8+ T cells, and minimize T cell exhaustion.
Meiling Jin, Shuzhen Liu, Mingshuo Zhan, Jian‐Dong Huang   +3 more
wiley   +1 more source

Enhancing the neural differentiation capabilities of genetically asymmetric mouse F1 hybrid embryonic stem cell lines. [PDF]

Exp Anim
Saito A, Kato H, Kiyosawa H.
europepmc   +1 more source

Role of cell–cell adhesion complexes in embryonic stem cell biology

Journal of Cell Science, 2014
T. Pieters, F. van Roy
semanticscholar   +1 more source

Hosts and Commensal Bacteria Synergistically Antagonize Opportunistic Pathogens at the Single‐Cell Resolution

Advanced Science, EarlyView.
In the tripartite‐species model, Drosophila larvae stimulate lactate production through excreting digestion enzymes. S. marcescens population senses a cue of lactate and tends to diverge into virulent and reduced virulence subclusters with remarkable heterogeneity to metabolize carbon metabolism and counter colonization resistance, giving a fitness ...
Sheng Zhang, Ziguang Wang, Anqi Liu, Jinshu Li, Jingjing Zhuang, Xiaowen Ji, Paul I. Mulama, Maoye Li, Haiqun Cao, Eng‐King Tan, Wei Liu   +10 more
wiley   +1 more source

Embryonic Stem Cell Differentiation to Definitive Endoderm As a Model of Heterogeneity Onset During Germ Layer Specification. [PDF]

Acta Naturae
Gordeev MN, Zinovyeva AS, Petrenko EE, Lomert EV, Aksenov ND, Tomilin AN, Bakhmet EI.   +6 more
europepmc   +1 more source

Establishment of New Embryonic Stem (ES) Cell Lines from C57BL/6 Strain Mice by Whole Blastocyst Culture Method.

, 1996
Makoto Osonoi, Sang-Yong Kim, Jutaro Takahashi, Yasuhisa YASUDA   +3 more
openalex   +2 more sources

A Cre-lox recombination system for the targeted integration of circular yeast artificial chromosomes into embryonic stem cells [PDF]

, 2000
Linda Call
openalex   +1 more source