Results 291 to 300 of about 1,293,017 (382)

HDAC6 and USP9X Control Glutamine Metabolism by Stabilizing GS to Promote Glioblastoma Tumorigenesis

Advanced Science, EarlyView.
Glioblastoma (GBM) growth relies on glutamine synthetase (GS), which is stabilized by histone deacetylase 6 (HDAC6) and deubiquitinated by ubiquitin‐specific peptidase 9, X‐linked (USP9X). HDAC6 promotes GS deacetylation, while USP9X removes its K48‐linked polyubiquitination, enhancing GS stability.
Go Woon Kim, Minhae Cha, Hien Thi My Ong, Jung Yoo, Yu Hyun Jeon, Sang Wu Lee, Soo Yeon Oh, Min‐Jung Kang, Youngsoo Kim, So Hee Kwon   +9 more
wiley   +1 more source

RNA binding protein with multiple splicing (RBPMS) promotes contractile phenotype splicing in human embryonic stem cell-derived vascular smooth muscle cells. [PDF]

Cardiovasc Res
Jacob AG, Moutsopoulos I, Petchey A, Kollyfas R, Knight-Schrijver VR, Mohorianu I, Sinha S, Smith CWJ.   +7 more
europepmc   +1 more source

Modulation of β-catenin function maintains mouse epiblast stem cell and human embryonic stem cell self-renewal

Nature Communications, 2013
Hoon Kim, Jun Wu, Shoudong Ye, Chih-I Tai, Xingliang Zhou, Hexin Yan, Ping Li, M. Pera, Qi-Long Ying   +8 more
semanticscholar   +1 more source

Colorectal Cancer Cells–Derived Exosomal PIK3CA Mutation DNA Promotes Tumor Metastasis by Activating Fibroblast and Affecting Tumor Metastatic Microenvironment

Advanced Science, EarlyView.
PIK3CAH1047R DNA in colorectal cancer (CRC) cell‐derived exosomes can be delivered into recipient fibroblasts, where it is transcribed and translated, leading to the activation of fibroblasts into cancer‐associated fibroblasts, which secrete elevated levels of IL6. The simultaneous detection and targeting of PIK3CAH1047R mutation and IL6 may serve as a
Rui Wang, Wanming Li, Yuqiong Lv, Wei Ba, Ying Jiang, Xiaoshuai Li, Jin Fang   +6 more
wiley   +1 more source

Optimized administration of human embryonic stem cell-derived immunity-and-matrix regulatory cells for mouse lung injury and fibrosis. [PDF]

Stem Cell Res Ther
Song D, Li Z, Sun F, Wu K, Zhang K, Liu W, Liu K, An B, Wang Z, Zhao T, Chen H, Xiao L, Wang L, Xie L, Li W, Peng L, Hao J, Wu J, Dai H.   +18 more
europepmc   +1 more source

Limited Gene Expression Variation in Human Embryonic Stem Cell and Induced Pluripotent Stem Cell‐Derived Endothelial Cells

Stem Cells, 2013
Mark P. White, A. J. Rufaihah, Lei Liu, Yohannes T. Ghebremariam, Kathryn N. Ivey, J. Cooke, D. Srivastava   +6 more
semanticscholar   +1 more source

Nephronectin (NPNT) is a Crucial Determinant of Idiopathic Pulmonary Fibrosis: Modulating Cellular Senescence via the ITGA3/YAP1 Signaling Axis

Advanced Science, EarlyView.
Through a comprehensive multi‐omics analysis, this study identifies a marked reduction in Nephronectin (NPNT) expression within fibrotic lung tissue. This reduction impairs the binding capability to the ITGA3 receptor, consequently causing YAP1 to persist in the cytoplasm, where it undergoes degradation.
Jiayu Guo, Yan Wang, Qiudi Liu, Zhaoyang Luo, Xiaomu Tian, Yuquan Wang, Yang Liu, Zhiwei Ning, Yingying Guo, Huiying Gao, Xinyue Wang, Jinglong Feng, Mengmeng Liu, Dina Saifullina, Yixin Zhang, Tengfei Pan, Yu Bian, Tao Ban, Tianyu Li, Yunyan Gu, Haihai Liang   +20 more
wiley   +1 more source

Correction to 'PRC2-independent actions of H3.3K27M in embryonic stem cell differentiation'. [PDF]

Nucleic Acids Res, 2023
europepmc   +1 more source

Maternal germ-line transmission of mutant mtDNAs from embryonic stem cell-derived chimeric mice

, 2000
James E. Sligh, Shawn Levy, Katrina G. Waymire, Paulette Allard, Dirck L. Dillehay, Steven Nusinowitz, John R. Heckenlively, Grant R. MacGregor, Douglas C. Wallace   +8 more
openalex   +1 more source

Enhancer decommissioning by LSD1 during embryonic stem cell differentiation

Nature, 2012
Warren A. Whyte, S. Bilodeau, David A. Orlando, Heather A. Hoke, G. Frampton, Charles T. Foster, S. Cowley, R. Young   +7 more
semanticscholar   +1 more source