Results 341 to 350 of about 1,293,017 (382)
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2014
Preimplantation embryo development sets the stage for pluripotency Regenerative medicine has the potential to revolutionize health care by offering the promise of replacement cells, tissues, and organs to combat injury, disease, and aging. In an ideal setting, stem cell therapies would begin with a pluripotent cell that by definition is able to give ...
Irina Klimanskaya +2 more
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Preimplantation embryo development sets the stage for pluripotency Regenerative medicine has the potential to revolutionize health care by offering the promise of replacement cells, tissues, and organs to combat injury, disease, and aging. In an ideal setting, stem cell therapies would begin with a pluripotent cell that by definition is able to give ...
Irina Klimanskaya +2 more
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The Nature of Embryonic Stem Cells
Annual Review of Cell and Developmental Biology, 2014Mouse embryonic stem (ES) cells perpetuate in vitro the broad developmental potential of naïve founder cells in the preimplantation embryo. ES cells self-renew relentlessly in culture but can reenter embryonic development seamlessly, differentiating on schedule to form all elements of the fetus.
MARTELLO, GRAZIANO, Austin Smith
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Differentiation of Embryonic Stem Cells
Current Protocols in Neuroscience, 2009AbstractMouse embryonic stem (ES) cells are derived from mouse blastocyst and are able to generate all embryonic tissues in vitro. This propensity of ES cells has acquired considerable attention in recent years due to the promising potential for future cell replacement–based therapies.
Kerstin Krieglstein +4 more
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Pluripotency of embryonic stem cells
Cell and Tissue Research, 2007Embryonic stem (ES) cells derived from pre-implantation embryos have the potential to differentiate into any cell type derived from the three germ layers of ectoderm (epidermal tissues and nerves), mesoderm (muscle, bone, blood), and endoderm (liver, pancreas, gastrointestinal tract, lungs), including fetal and adult cells.
Yamanaka, S +7 more
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2013
Embryonic development prior to implantation of the embryo in the uterus includes a stage of blastocyst formation, where the initial mass of cells is segregated into an inner cell mass (ICM) that is destined to contribute to the developing embryo, and an outer layer of cells that will contribute to the fetal portion of the placenta.
Junying Yu, James A. Thomson
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Embryonic development prior to implantation of the embryo in the uterus includes a stage of blastocyst formation, where the initial mass of cells is segregated into an inner cell mass (ICM) that is destined to contribute to the developing embryo, and an outer layer of cells that will contribute to the fetal portion of the placenta.
Junying Yu, James A. Thomson
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The Validated Embryonic Stem Cell Test with Murine Embryonic Stem Cells
2018Birth defects are the leading cause of infant mortality in the USA, yet the causes of most of these conditions are unknown. While a combination of genetic and environmental factors are suspected in most cases, little information exists about the health risks that prenatal exposure to many common chemicals poses for the fetus.
Darcie L V McClelland-Descalzo +2 more
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Neurosurgery Clinics of North America, 2007
Human embryonic stem cells (hESCs) are stable in terms of their pluripotency, karyotype, global gene expression, ability to repair DNA and maintain telomerase levels, and growth characteristics. hESCs offer a renewable source of a wide range of cell types for use in research and cell-based therapies to treat disease.
Cleo Choong +2 more
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Human embryonic stem cells (hESCs) are stable in terms of their pluripotency, karyotype, global gene expression, ability to repair DNA and maintain telomerase levels, and growth characteristics. hESCs offer a renewable source of a wide range of cell types for use in research and cell-based therapies to treat disease.
Cleo Choong +2 more
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2021
The earliest source of stem cells in humans are embryos at the blastocyst stage (a hollow ball of about 150–200 cells that is 4–5 days old) of their development. Such cells are identified and collected mainly from surplus embryos discarded after in vitro fertilization (IVF). The procedure requires destruction of the blastocyst.
Maria do Céu Patrão Neves +1 more
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The earliest source of stem cells in humans are embryos at the blastocyst stage (a hollow ball of about 150–200 cells that is 4–5 days old) of their development. Such cells are identified and collected mainly from surplus embryos discarded after in vitro fertilization (IVF). The procedure requires destruction of the blastocyst.
Maria do Céu Patrão Neves +1 more
openaire +2 more sources
Journal of Cell Science, 2000
ABSTRACT Embryonic stem (ES) cells are cells derived from the early embryo that can be propagated indefinitely in the primitive undifferentiated state while remaining pluripotent; they share these properties with embryonic germ (EG) cells. Candidate ES and EG cell lines from the human blastocyst and embryonic gonad can differentiate into
Martin F. Pera +2 more
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ABSTRACT Embryonic stem (ES) cells are cells derived from the early embryo that can be propagated indefinitely in the primitive undifferentiated state while remaining pluripotent; they share these properties with embryonic germ (EG) cells. Candidate ES and EG cell lines from the human blastocyst and embryonic gonad can differentiate into
Martin F. Pera +2 more
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2012
The embryonic stem cell test is an animal-free alternative test method for developmental toxicity. Mouse embryonic stem cells are cultured in a hanging drop method to form embryoid bodies. These embryoid bodies, when plated on tissue culture dishes, differentiate to form contracting myocardial cell foci within 10 days.
Sjors H.W. Schulpen, Aldert H. Piersma
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The embryonic stem cell test is an animal-free alternative test method for developmental toxicity. Mouse embryonic stem cells are cultured in a hanging drop method to form embryoid bodies. These embryoid bodies, when plated on tissue culture dishes, differentiate to form contracting myocardial cell foci within 10 days.
Sjors H.W. Schulpen, Aldert H. Piersma
openaire +3 more sources