Results 81 to 90 of about 1,324,654 (403)
FEBS Open Bio, EarlyView.Cerebral organoids were employed as a novel model to explore the neurotoxicity of soman. Soman inhibited acetylcholinesterase activity, increased cell apoptosis and upregulated endoplasmic reticulum (ER) stress markers glucose‐regulated protein 78 (GRP78), activating transcription factor 6 (ATF6) and C/EBP homologous protein (CHOP).
Yue Wei +7 more
wiley +1 more source
Stem Cells International, 2016 Although human pluripotent stem cells (hPSCs) can proliferate robustly on the feeder-free culture system, genetic instability of hPSCs has been reported in such environment. Alternatively, feeder cells enable hPSCs to maintain their pluripotency.
Ruttachuk Rungsiwiwut +5 more
doaj +1 more source
Recognition and reconstruction of cell differentiation patterns with deep learning [PDF]
arXiv, 2022 Cell lineage decisions occur in three-dimensional spatial patterns that are difficult to identify by eye. There is an ongoing effort to replicate such patterns using mathematical modeling. One approach uses long ranging cell-cell communication to replicate common spatial arrangements like checkerboard and engulfing patterns.
arxiv
Mass-spectrometry of single mammalian cells quantifies proteome heterogeneity during cell differentiation [PDF]
Genome Biology, 2018, 2018 Cellular heterogeneity is important to biological processes, including cancer and development. However, proteome heterogeneity is largely unexplored because of the limitations of existing methods for quantifying protein levels in single cells. To alleviate these limitations, we developed Single Cell ProtEomics by Mass Spectrometry (SCoPE-MS), and ...
arxiv +1 more source
Journal of Nanobiotechnology, 2023 Dihydroartemisinin (DHA), a natural product derived from the herbal medicine Artemisia annua, is recently used as a novel anti-cancer agent. However, some intrinsic disadvantages limit its potential for clinical management of cancer patients, such as ...
Yuanliang Yan +8 more
doaj +1 more source
A history of embryonic stem cell research: Concepts, laboratory work, and contexts [PDF]
, 2017 This thesis focuses on the history of embryonic stem cell research, spanning in particular the nineteenth and twentieth centuries. As yet, there has not been a comprehensive history of embryonic stem cell research carried out, which is a particular aim ...
LANCASTER, CHERYL
core
Advanced Biology, EarlyView.By systematizing a large body of evidence and propose a cascade relationship between protein homeostasis, endoplasmic reticulum stress, mitochondrial dysfunction, and pro‐fibrotic factor, providing a theoretical basis for ATII cells dysfunction as a possible pathophysiological initiating event for idiopathic pulmonary fibrosis.
Zhaoxiong Dong +6 more
wiley +1 more source
Hadassah, provider of 'Regulatory-Ready' pluripotent clinical-grade stem cell banks
Stem Cell Research, 2020 The Hadassah hESC Research Center's aim is to be a supplier of clinical and research-grade human embryonic stem cell (hESC) lines. In 2012, we derived the first three entirely GMP-compliant and xeno-free, fully-characterised, feeder-dependent (human ...
Shelly E Tannenbaum +7 more
doaj
BMC Complementary Medicine and Therapies, 2021 Background An emerging body of evidence indicates that puerarin (PUE) plays an important role in the treatment of angina pectoris, myocardial ischemia-reperfusion injury, hypertension and other cardiovascular diseases, but how PUE affects the vascular ...
Xiaoxia Fang +14 more
doaj +1 more source
Epigenetic Tracking: a Model for Multicellular Biology [PDF]
arXiv, 2013 Epigenetic Tracking is a mathematical model of biological cells, originally conceived to study embryonic development. Computer simulations proved the capacity of the model to generate complex 3-dimensional cellular structures, and the potential to reproduce the complexity typical of living beings.
arxiv