Results 81 to 90 of about 537,037 (306)

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

Human Umbilical Cord Blood-Derived Serum for Culturing the Supportive Feeder Cells of Human Pluripotent Stem Cell Lines

Stem Cells International, 2016
Although human pluripotent stem cells (hPSCs) can proliferate robustly on the feeder-free culture system, genetic instability of hPSCs has been reported in such environment. Alternatively, feeder cells enable hPSCs to maintain their pluripotency.
Ruttachuk Rungsiwiwut, Praewphan Ingrungruanglert, Pranee Numchaisrika, Pramuan Virutamasen, Tatsanee Phermthai, Kamthorn Pruksananonda   +5 more
doaj   +1 more source

Produksi Embryonic Stem Cell (Esc) Line Dari Blastosis Mencit Dengan Metode Immunosurgery [PDF]

, 2014
Embryonic Stem Cells (ESC) are pluripotent stem cells which has the ablility to self renew and differentiate into form all cells in the body. Inner Cell Mass (ICM) as a source of ESC that can be obtained from blastocyst stage of embryos. Isolation can be
Rinendyaputri, R. (Ratih), Susanti, N. (Nike)   +1 more
core  

The rate of X-ray-induced DNA double-strand break repair in the embryonic mouse brain is unaff ected by exposure to 50 Hz magnetic fi elds [PDF]

, 2015
Following in utero exposure to low dose radiation (10 – 200 mGy), we recently observed a linear induction of DNA double-strand breaks (DSB) and activation of apoptosis in the embryonic neuronal stem/progenitor cell compartment.
Ahlbom IC, Bayer SA, Brenner DJ, Cox J, Crumpton MJ, Ding GR, Draper G, Elizabeth Ainsbury, Fedele G, Gatz SA, Greenland S, International Agency for Research on Cancer (IARC), Ivancsits S, Jackie Haines, Kabacik S, Lagroye I, Lara Barazzuol, Lisa Woodbine, Luukkonen J, Luukkonen J, Maeda K, Mairs RJ, Margaret Coster, Mettler FA, Mitsuhashi T, O’Dea AR, Penny Jeggo, Pontious A, World Health Organization (WHO), Zenon Sienkiewicz, Zhao L   +30 more
core   +2 more sources

Developmental, Neuroanatomical and Cellular Expression of Genes Causing Dystonia

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Dystonia is one of the most common movement disorders, with variants in multiple genes identified as causative. However, an understanding of which developmental stages, brain regions, and cell types are most relevant is crucial for developing relevant disease models and therapeutics.
Darren Cameron, Nicholas E. Clifton, Daniel Cabezas de la Fuente, Peter Holmans, Nicholas J. Bray, Kathryn J. Peall   +5 more
wiley   +1 more source

Mechanisms of action of hESC-secreted proteins that enhance human and mouse myogenesis. [PDF]

, 2014
Adult stem cells grow poorly in vitro compared to embryonic stem cells, and in vivo stem cell maintenance and proliferation by tissue niches progressively deteriorates with age.
CONBOY, Irina M, Conboy, Michael, Mamiya, Hikaru, Schaffer, David, Schlesinger, Christina, Yousef, Hanadie, Zeiderman, Matthew   +6 more
core   +3 more sources

Super‐Refractory Status Epilepticus (SRSE) in a Patient With Compound Heterozygous OPA1 Variants: Case Report and Literature Review

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi, Lara Basovic, Christopher Michael McGraw   +2 more
wiley   +1 more source

Trimethylamine N-oxide promotes the proliferation and migration of hepatocellular carcinoma cell through the MAPK pathway

Discover Oncology
Trimethylamine-n-oxide (TMAO) is a metabolite of intestinal flora following the consumption of phosphatidylcholine-rich foods. Clinical cohort studies have shown that plasma TMAO may be a risk factor for cancer development, including hepatocellular ...
Chunfang Zhou, Rina Basnet, Chenxiang Zhen, Shinan Ma, Xingrong Guo, Zhongxia Wang, Yahong Yuan   +6 more
doaj   +1 more source

Conventional pluripotency markers are unspecific for bovine embryonic-derived cell-lines [PDF]

, 2013
Bovine embryonic stem cells are of potentially big value in transgenic research and studies of lineage commitment and development. Nevertheless, key aspects of the establishment of bovine embryonic stem cells such as the identification of specific ...
Caamaño, J.N. (José), Díez, C., Facal, Nieves, Frutos, C., Gómez, E., Muñoz, M., Rodríguez, A.   +6 more
core  

Signalling, cell cycle and pluripotency in embryonic stem cells [PDF]

, 2002
International ...
Burdon, Tom, Savatier, Pierre, Smith, Austin   +2 more
core   +1 more source