New Perspectives on Semiconducting Conjugated Oligomers for Neuromodulation in Hydra vulgaris
Semiconducting organic compounds, thiophene‐based, modify the rhythmic electrical activity of the cnidarian Hydra vulgaris acting on specific neuronal circuits. The ETE‐S trimer also forms electronically conducting wires in the living tissues of the animal.
Giuseppina Tommasini+7 more
wiley +1 more source
Lipofection improves gene targeting efficiency in E14 TG2a mouse embryonic stem cells [PDF]
Electroporation has been the method of election for transfection of murine embryonic stem cells for over 15 years; however, it is a time consuming protocol because it requires large amounts of DNA and cells, as well as expensive and delicate equipment ...
ALONSO MORALES, ROGELIO ALEJANDRO+13 more
core
Peri‐implant soft tissue integration (STI), weaker than natural teeth, raises peri‐implant disease risk. Gingival‐region material surface properties critically modulate soft‐tissue responses, driving surface modifications to enhance STI. This review provides an in‐depth analysis of the challenges of STI around dental implants, comprehensively reviews ...
Shasha Jia+5 more
wiley +1 more source
4D Bioprinted Self‐Folding Scaffolds Enhance Cartilage Formation in the Engineering of Trachea
A bilayer self‐folding scaffold, triggerable by humidity, is fabricated via 4D bioprinting for trachea engineering. An analytical model is derived to predict its radius of curvature, enabling its scalability. Cartilage progenitor cells seeded on the scaffold perceive scaffold final curvature and react to it, by enhancing the upregulation of pro ...
Irene Chiesa+4 more
wiley +1 more source
Conventional pluripotency markers are unspecific for bovine embryonic-derived cell-lines [PDF]
Bovine embryonic stem cells are of potentially big value in transgenic research and studies of lineage commitment and development. Nevertheless, key aspects of the establishment of bovine embryonic stem cells such as the identification of specific ...
Caamaño, J.N. (José)+6 more
core
Emerging Therapeutic Strategies for Hearing Loss
Challenges still exist in treating hearing loss in cases of severe damage to hair cells or spiral ganglion neurons. Here, a schematic diagram of cochlear sensory hair cells and auditory nerves is presented. It is found that in normal Corti organs, hair cells have upright stereocilia at the top and auditory neurons at the base. Ototoxic drugs, noise, or
Shanying Han+9 more
wiley +1 more source
The CRL7FBXW8 Complex Controls the Mammary Stem Cell Compartment through Regulation of NUMB Levels
In breast cancer (BC), NUMB loss of function (LOF) is common and mainly driven by protein hyper‐degradation. The CRL7FBXW8 complex is the E3 ligase responsible for NUMB degradation. Inhibition of CRL7FBXW8 in NUMB‐LOF BC cells restores NUMB levels, and decreases the number of cancer stem cells and tumorigenic ability in vivo. Targeting CRL7FBXW8 offers
Simone Sabbioni+16 more
wiley +1 more source
The Role and Fate of DNA Ends for Homologous Recombination in Embryonic Stem Cells [PDF]
Paul Hasty+2 more
openalex +1 more source
Advances in Microfluidic Cochlea‐On‐A‐Chip
This review systematically examines diverse cell sources for inner ear organoids and outlines stepwise induction protocols. Furthermore, it discusses current applications and prospective developments of cochlea‐on‐a‐chip technologies in areas such as deafness modeling, mechanistic studies, and drug evaluation, with particular focus on gene‐therapy drug
Tian Shen+10 more
wiley +1 more source
A DNA signal from the Thy-1 gene defines de novo methylation patterns in embryonic stem cells. [PDF]
Moshe Szyf+2 more
openalex +1 more source