Results 141 to 150 of about 1,367,138 (398)

Translational Considerations for Injectable Biomaterials and Bioscaffolds to Repair and Regenerate Brain Tissue

Advanced Healthcare Materials, EarlyView.
The repair and regeneration of brain tissue faces both biological and technical challenges. Injectable bioscaffolds offer new opportunities to stimulate tissue regrowth in the brain by recruiting neural stem cells. Here, the translational issues are reviewed that need to be address to advance this promising new therapeutic approach from the bench to ...
Michel Modo, Alena Kisel
wiley   +1 more source

Human Endometrial Extracellular Matrix Hydrogel Facilitated Endometrial Mesenchymal Stem Cells for Endometrial Regeneration

Advanced Healthcare Materials, EarlyView.
Adequate thickness of the uterine lining is crucial for women with thin or damaged endometrium to achieve pregnancies. Endometrial mesenchymal stem cells (eMSC) can facilitate the cyclical repair and regeneration of the human endometrium. In this study, the human endometrium derived extracellular matrix hydrogel supports the growth of eMSC promoting ...
Jingwen Xu, Philip C N Chiu, Ernest H Y Ng, Sentao Hu, Zi Ye, Liaobing Xin, Lie Ma, Songying Zhang, William S B Yeung, Rachel W S Chan   +9 more
wiley   +1 more source

Induction of Pluripotent Stem Cells from Mouse Embryonic and Adult Fibroblast Cultures by Defined Factors

Cell, 2006
Kazutoshi Takahashi, S. Yamanaka
semanticscholar   +1 more source

Introduction of a point mutation into the mouse genome by homologous recombination in embryonic stem cells using a replacement type vector with a selectable marker [PDF]

, 1993
Marcelo Rubinstein, Miguel Á. Japón, Malcolm J. Low   +2 more
openalex   +1 more source

A Human Kidney Tubuloid Model of Repeated Cisplatin‐Induced Cellular Senescence and Fibrosis for Drug Screening

Advanced Healthcare Materials, EarlyView.
Replicating aging and senescence‐related pathophysiological responses in kidney organoids remains a significant challenge. Human adult renal tubular organoid, tubuloids, are successfully developed recapitulating cellular senescence that is the central pathophysiological mechanism of chronic kidney disease (CKD).
Yuki Nakao, Makiko Mori, Yuta Sekiguchi, Iori Morita, Ryota Shindoh, Shintaro Mandai, Tamami Fujiki, Hiroaki Kikuchi, Fumiaki Ando, Koichiro Susa, Takayasu Mori, Ayumi Suzuki, Yuji Nashimoto, Hirokazu Kaji, Yuma Waseda, Soichiro Yoshida, Yasuhisa Fujii, Eisei Sohara, Shinichi Uchida, Kensuke Miyake, Yutaro Mori   +20 more
wiley   +1 more source

Core Transcriptional Regulatory Circuitry in Human Embryonic Stem Cells

Cell, 2005
L. Boyer, Tong Ihn Lee, Megan F. Cole, Sarah E. Johnstone, S. Levine, J. Zucker, M. Guenther, Roshan M. Kumar, H. L. Murray, Richard G. Jenner, D. Gifford, D. Melton, R. Jaenisch, R. Young   +13 more
semanticscholar   +1 more source

3D‐Printed Multidimensional Bionic Mg‐MC/PLGA Composite for Tailored Repair of Segmental Long Bone Defects

Advanced Healthcare Materials, EarlyView.
This study develops 3D‐printed Mg‐MC/PLGA scaffolds with varying Mg concentrations (0–20%). The 5% Mg scaffold shows optimal cytocompatibility, osteogenic activity in vitro, and significantly enhances bone regeneration in rabbits, improving bone volume and mechanical strength.
Shihang Liu, Shuai Zhou, Tingting Zou, Guangzhao Hou, Qian Xiao, Lin Li, Jianjun Yang, Wei Chen, Yingze Zhang, Hongzhi Lv   +9 more
wiley   +1 more source

Engineering Extracellular Microenvironments: The Impact of Fibrous Materials on Cell Behavior

Advanced Healthcare Materials, EarlyView.
Fibrous structures are key elements of the native extracellular matrix and crucial for directing cell behavior. This review discusses how fiber properties such as composition, diameter, and alignment affect cell responses in 2D and 3D systems. Strategies for integrating fibrous cues into engineered tissues are highlighted, and future directions for ...
Zan Lamberger, Gregor Lang
wiley   +1 more source

Development of chick embryo explant cultures as an assay system to test mammalian stem cell migration and differentiation after transplantation [PDF]

, 2004
only availableStem cells are undifferentiated cells capable of achieving multiple developmental fates. The embryonic stem (ES) cell can differentiate into all cells of the body.
Jackson, Teresa, Joshua, Gina, Kirk, Mark D., Meyer, Jason, O'Connell, Sinead, Struckhoff, Jessica, Whitehead, Zach   +6 more
core  

Functional Expression Cloning of Nanog, a Pluripotency Sustaining Factor in Embryonic Stem Cells

Cell, 2003
I. Chambers, Douglas Colby, M. Robertson, J. Nichols, Sonia A Lee, S. Tweedie, Austin G Smith   +6 more
semanticscholar   +1 more source