Results 201 to 210 of about 1,274,889 (380)

NF2 is Essential for Human Endoderm Development

Advanced Science, EarlyView.
This study demonstrates that NF2, moesin‐ezrin‐radixin like (MERLIN) tumor suppressor (NF2) is essential for human endoderm formation. NF2 knockout human induced pluripotent stem cells fail to form endoderm both in vitro and in vivo due to yes‐associated protein 1 (YAP1) nuclear translocation, redirecting differentiation toward myofibroblast‐like cells.
Minjin Jeong, Dongjun Han, Preetida Bhetariya, D. Bradley Welling, Miodrag Stojkovic, Konstantina M. Stankovic   +5 more
wiley   +1 more source

Capture of Totipotency in Mouse Embryonic Stem Cells in the Absence of Pdzk1. [PDF]

Adv Sci (Weinh)
Zhang W, Zhao Y, Yang Z, Yan J, Wang H, Nie S, Jia Q, Ding D, Tong C, Zhang XO, Gao Q, Shuai L.   +11 more
europepmc   +1 more source

Derivation of melanocytes from embryonic stem cells in culture [PDF]

, 1999
Toshiyuki Yamane, Shinichi Hayashi, Masako Mizoguchi, Hidetoshi Yamazaki, Takahiro Kunisada   +4 more
openalex   +1 more source

DNA methylation on N6-adenine in mammalian embryonic stem cells

Nature, 2016
Tao P. Wu, Tao Wang, M. Seetin, Yongquan Lai, Shijia Zhu, Kaixuan Lin, Yifei Liu, S. Byrum, S. Mackintosh, Mei Zhong, A. Tackett, Guilin Wang, Lawrence S. Hon, Gang Fang, J. Swenberg, A. Xiao   +15 more
semanticscholar   +1 more source

CK2B Induces CD8+ T‐Cell Exhaustion through HDAC8‐Mediated Epigenetic Reprogramming to Limit the Efficacy of Anti‐PD‐1 Therapy in Non‐Small‐Cell Lung Cancer

Advanced Science, EarlyView.
αPD‐1 therapy has left an indelible mark in the field of NSCLC treatment; however, its efficacy is limited in clinical practice owing to the effector T‐cell exhaustion. These findings underscore CK2B as a promising target for overcoming the exhaustion of effector CD8+ T cells, thereby enhancing the efficacy of αPD‐1 and adoptive cell therapies in NSCLC.
Shaochuan Liu, Shiya Ma, Gen Liu, Lingjie Hou, Yong Guan, Liang Liu, Yuan Meng, Wenwen Yu, Ting Liu, Li Zhou, Zhiyong Yuan, Shuju Pang, Siyuan Zhang, Junyi Li, Xiubao Ren, Qian Sun   +15 more
wiley   +1 more source

Dual-Selection Strategy for Generating Knock-Out Lines of Human Embryonic Stem Cells. [PDF]

J Cell Mol Med
Zhou Z, Tong L, Chen Y, Wang R, Shen Y, Chen D.   +5 more
europepmc   +1 more source

Synthetic Lethality of SHP2 and XIAP Suppresses Proliferation and Metastasis in KRAS‐mutant Nonsmall Cell Lung Cancer

Advanced Science, EarlyView.
Embelin cotargets SHP2 to disrupt the SHP2/GRB2/SOS complex, inhibiting cancer‐related signaling pathways such as MAPK, (PI3K)/AKT pathway, and XIAP to induce apoptosis signaling pathway, respectively, leading to synthetic lethality in KRAS‐mutant NSCLC cells both in vivo and in vitro.
Nai‐jie Fu, Yu‐wen Sheng, Zhe Fan, Zhao Wu, Ling‐yu Li, Rui‐ying Xi, Xiao‐ke Shi, Guo‐lin Zhang, Fei Wang   +8 more
wiley   +1 more source

ERK phosphorylates ESRRB to regulate the self-renewal and differentiation of mouse embryonic stem cells. [PDF]

Stem Cell Reports
Duan X, Zhang Q, Gao L, Ling B, Du X, Chen L.   +5 more
europepmc   +1 more source

Non-CpG methylation is prevalent in embryonic stem cells and may be mediated by DNA methyltransferase 3a [PDF]

, 2000
Bernard Ramsahoye, Detlev Biniszkiewicz, Frank Lyko, Victoria H. Clark, Adrian Bird, Rudolf Jaenisch   +5 more
openalex   +1 more source

From Invaginating Site to Deep Lesion: Spatial Transcriptomics Unravels Ectopic Endometrial Penetration Features in Adenomyosis

Advanced Science, EarlyView.
This work utilizes spatial transcriptomics to map the transcriptional landscape of adenomyosis with obvious invagination structure from the invaginating site to deep lesions. By integrating with single‐cell RNA sequencing, this study elucidates the molecular features of invagination, invasion, and fibrosis, and finds the major participants and vital ...
Boyu Li, Jia Qi, Yumeng Cao, Yijing Long, Zhe Wei, Wang‐Sheng Wang, Shuanggang Hu, Yuan Wang, Qinling Zhu, Xiao Hu, Zhe Sun, Jie Zhu, Taiyang Ye, Yejie Yao, Yiwen Meng, Xuejiao Bian, Xinyi Dong, Hengyu Guan, Yunfei Huang, Yun Sun   +19 more
wiley   +1 more source