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The Validated Embryonic Stem Cell Test with Murine Embryonic Stem Cells
2018Birth defects are the leading cause of infant mortality in the USA, yet the causes of most of these conditions are unknown. While a combination of genetic and environmental factors are suspected in most cases, little information exists about the health risks that prenatal exposure to many common chemicals poses for the fetus.
Darcie L V McClelland-Descalzo +2 more
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2021
The earliest source of stem cells in humans are embryos at the blastocyst stage (a hollow ball of about 150–200 cells that is 4–5 days old) of their development. Such cells are identified and collected mainly from surplus embryos discarded after in vitro fertilization (IVF). The procedure requires destruction of the blastocyst.
Maria do Céu Patrão Neves +1 more
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The earliest source of stem cells in humans are embryos at the blastocyst stage (a hollow ball of about 150–200 cells that is 4–5 days old) of their development. Such cells are identified and collected mainly from surplus embryos discarded after in vitro fertilization (IVF). The procedure requires destruction of the blastocyst.
Maria do Céu Patrão Neves +1 more
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2013
Embryonic development prior to implantation of the embryo in the uterus includes a stage of blastocyst formation, where the initial mass of cells is segregated into an inner cell mass (ICM) that is destined to contribute to the developing embryo, and an outer layer of cells that will contribute to the fetal portion of the placenta.
Junying Yu, James A. Thomson
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Embryonic development prior to implantation of the embryo in the uterus includes a stage of blastocyst formation, where the initial mass of cells is segregated into an inner cell mass (ICM) that is destined to contribute to the developing embryo, and an outer layer of cells that will contribute to the fetal portion of the placenta.
Junying Yu, James A. Thomson
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Neurosurgery Clinics of North America, 2007
Human embryonic stem cells (hESCs) are stable in terms of their pluripotency, karyotype, global gene expression, ability to repair DNA and maintain telomerase levels, and growth characteristics. hESCs offer a renewable source of a wide range of cell types for use in research and cell-based therapies to treat disease.
Cleo Choong +2 more
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Human embryonic stem cells (hESCs) are stable in terms of their pluripotency, karyotype, global gene expression, ability to repair DNA and maintain telomerase levels, and growth characteristics. hESCs offer a renewable source of a wide range of cell types for use in research and cell-based therapies to treat disease.
Cleo Choong +2 more
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Best Practice & Research Clinical Obstetrics & Gynaecology, 2016
The establishment of permanent human embryonic stem cell lines (hESCs) was first reported in 1998. Due to their pluripotent nature and ability to differentiate to all cell types in the body, they have been considered as a cell source for regenerative medicine. Since then, intensive studies have been carried out regarding factors regulating pluripotency
Karl Tryggvason +6 more
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The establishment of permanent human embryonic stem cell lines (hESCs) was first reported in 1998. Due to their pluripotent nature and ability to differentiate to all cell types in the body, they have been considered as a cell source for regenerative medicine. Since then, intensive studies have been carried out regarding factors regulating pluripotency
Karl Tryggvason +6 more
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Trends in Cell Biology, 2012
Embryonic stem cells (ESCs) - undifferentiated cells originating from preimplantation stage embryos - have prolonged self-renewal capacity and are pluripotent. Activation of the canonical Wnt pathway is implicated in maintenance of and exit from the pluripotent state. Recent findings demonstrate that the essential mediator of canonical Wnt signaling, β-
Christine Hartmann, Jason Wray
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Embryonic stem cells (ESCs) - undifferentiated cells originating from preimplantation stage embryos - have prolonged self-renewal capacity and are pluripotent. Activation of the canonical Wnt pathway is implicated in maintenance of and exit from the pluripotent state. Recent findings demonstrate that the essential mediator of canonical Wnt signaling, β-
Christine Hartmann, Jason Wray
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EMBRYONIC POTENTIAL AND STEM CELLS
Bioethics, 2007ABSTRACTThis paper examines three arguments that use the concept of potential to identify embryos that are morally suitable for embryonic stem cell research (ESCR). According to the first argument, due to Ronald Green, the fact that they are scheduled for disposal makes embryos left over from IVF treatments morally appropriate for research. Paul McHugh
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Journal of Cell Science, 2000
ABSTRACT Embryonic stem (ES) cells are cells derived from the early embryo that can be propagated indefinitely in the primitive undifferentiated state while remaining pluripotent; they share these properties with embryonic germ (EG) cells. Candidate ES and EG cell lines from the human blastocyst and embryonic gonad can differentiate into
Martin F. Pera +2 more
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ABSTRACT Embryonic stem (ES) cells are cells derived from the early embryo that can be propagated indefinitely in the primitive undifferentiated state while remaining pluripotent; they share these properties with embryonic germ (EG) cells. Candidate ES and EG cell lines from the human blastocyst and embryonic gonad can differentiate into
Martin F. Pera +2 more
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2005
Stem cells, which have a great capacity for self-renewal and can differentiate into at least one committed cell type, exist in embryonic and adult organisms of many phyla. Although stem cells of various types from mice and other lower organisms have been studied for many years, it was not until the derivation of stem cell lines from human embryos in ...
Jon S. Odorico, Victoria L. Browning
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Stem cells, which have a great capacity for self-renewal and can differentiate into at least one committed cell type, exist in embryonic and adult organisms of many phyla. Although stem cells of various types from mice and other lower organisms have been studied for many years, it was not until the derivation of stem cell lines from human embryos in ...
Jon S. Odorico, Victoria L. Browning
openaire +2 more sources