Results 101 to 110 of about 117,694 (268)

Time‐Restricted Eating on Appetite and Inflammation in Adults With Obesity and Prediabetes: A Randomized Feeding Study

Obesity, EarlyView.
ABSTRACT Objective Time‐restricted eating (TRE) has gained attention for weight loss and cardiometabolic health improvement. The Time‐Restricted Intake of Meals (TRIM) study was a 12‐week randomized isocaloric and eucaloric feeding trial comparing 10‐h TRE to a 16‐h usual eating pattern (UEP) in adults with obesity and either prediabetes or diet ...
Daisy Duan, Susan Carnell, Scott J. Pilla, Stephanie T. Chung, Jeanne M. Clark, Nisa M. Maruthur   +5 more
wiley   +1 more source

Nonwoven rCF/PA6 Thermoplastic Composites: Hybrid Commingled Fibers vs. Powder Impregnation—Effects on Microstructure and Mechanical Properties

Polymer Composites, EarlyView.
Comparison of powder impregnation and hybrid commingled non‐wovens for PA6/rCF nonwoven composites. The two‐step powder route gives lower voids and higher properties, while the single‐step hybrid route is limited by precursor inhomogeneity and high void content.
Gaia Francesca Lupia, Tommaso Pini, Ilaria Rossitti, Sara Taherinezhad Tayebi, Marco Valente   +4 more
wiley   +1 more source

Thermosensitive Nanostructured Coacervates Developed by Mixing ABA‐ and AB‐Block Copolymers and Their Unique Sustained Release of Nano‐Micelles in a Regulated Manner

Small, EarlyView.
Polyion complex micelles composed of blends of ABA and AB block copolymers can form coacervates with a hexagonally packed cylinder nanostructure after heating. The resulting coacervates can release the micelles under physiological conditions in a zero‐order kinetics, possessing cargo proteins.
Takumi Egashira, Hiroshi Kamizawa, Yujiro Hamada, Wataru Fushimoto, Hiroshi Y. Yoshikawa, Yuji Higaki, Atsushi Takahara, Takeshi Mori, Yoshiki Katayama, Akihiro Kishimura   +9 more
wiley   +1 more source

Bifunctional Electrocatalysts in Rechargeable Lithium‐Gas Batteries: Material Evolution and Mechanistic Insights from Metal‐Free Carbons to Carbon‐Supported Single‐Atom Sites

Small, EarlyView.
This review charts the material evolution of bifunctional electrocatalysts for rechargeable lithium‐gas batteries. It highlights the journey from heteroatom‐doped, metal‐free carbon architectures to precision‐engineered carbon‐supported single‐atom sites. The discussion focuses on mechanistic insights into how these catalysts govern reversible O2, CO2,
Daming Ren, Shuimei Chen, Yuzheng Wu, Xiaodan Huang, Jong Beom Baek, Ashok Kumar Nanjundan   +5 more
wiley   +1 more source

Immunogenicity of avelumab in patients with metastatic Merkel cell carcinoma or advanced urothelial carcinoma

Clinical and Translational Science
Like other monoclonal antibodies, immune checkpoint inhibitors may be immunogenic in some patients, potentially affecting pharmacokinetics (PKs) and clinical outcomes.
Ping Hu, Haiqing Isaac Dai, James Bourdage, Dongli Zhou, Ky Trang, Karey Kowalski, Carlo Bello, Jennifer Hibma, Akash Khandelwal, Kyra Cowan, Jennifer Dong, Karthik Venkatakrishnan, Wei Gao   +12 more
doaj   +1 more source

Juvenile and Pubertal Exposure to Polystyrene Nanoplastics Impairs Epididymal Structure and Sperm Quality in Mice

Environmental Toxicology, EarlyView.
ABSTRACT Nanoplastics (NPs) are emerging environmental contaminants capable of crossing biological barriers, accumulating in tissues, and disrupting physiological pathways. The male reproductive system is particularly vulnerable during the postnatal period, a developmental window characterized by intense testicular differentiation and epididymal ...
Gabriel Magalhães Oliveira Rigo, Nicoly Caixêta Gonçalves, Cristiana Livramento Oliveira Pinto, Patrícia Corona Lopes, Raul Silva Santarem, Juliana Reis Machado, Régia Caroline Peixoto Lira, Ana Paula Ramos, Marcos Vinicius da Silva, Hugo Felix Perini, Gláucia Eloisa Munhoz de Lion Siervo   +10 more
wiley   +1 more source

Model‐based meta‐analysis using latent variable modeling to set benchmarks for new treatments of systemic lupus erythematosus

CPT: Pharmacometrics & Systems Pharmacology
Several investigational agents are under evaluation in systemic lupus erythematosus (SLE) clinical trials but quantitative frameworks to enable comparison of their efficacy to reference benchmark treatments are lacking. To benchmark SLE treatment effects
Kosalaram Goteti, Ramon Garcia, William R. Gillespie, Jonathan French, Lena Klopp‐Schulze, Ying Li, Cristina Vazquez Mateo, Sanjeev Roy, Oliver Guenther, Lisa Benincosa, Karthik Venkatakrishnan   +10 more
doaj   +1 more source

Assessing the host plants of the invasive apricot aphid, Myzus mumecola (Hemiptera: Aphididae)

Agricultural and Forest Entomology, EarlyView.
We investigated the host plants of the invasive apricot aphid Myzus mumecola (Hemiptera: Aphididae), an emerging pest species in Europe, by combining molecular and ecological approaches. The winter host plant was confirmed as apricot by both methods.
Marta Chignola, Urban Spitaler, Hannes Schuler   +2 more
wiley   +1 more source

Factors Associated With Long‐Term Survivors With Epidermal Growth Factor Receptor Positive Non‐Small Cell Lung Cancer Treated With First or Second‐Generation Tyrosine Kinase Inhibitors: A Canadian Multi‐Center Cohort

Asia-Pacific Journal of Clinical Oncology, EarlyView.
In a multi‐center Canadian cohort of 577 patients with advanced epidermal growth factor receptor‐mutated non‐small cell lung cancer treated with first/second‐generation TKIs, Asian ancestry and female sex predicted longer survival, while the L858R mutation predicted shorter survival.
Heather Halperin, Amanda J. W. Gibson, Ali Hussein, Mike Sung, Pascale Tomasini, Michelle Dean, Jennifer H. Law, Cheryl Ho, Vishal Navani, Natasha B. Leighl, Desiree Hao   +10 more
wiley   +1 more source

Skin Abnormalities at Checkpoint Inhibitor Therapy Initiation Are Associated With Skin Rash Development in Oncology Patients

Allergy, EarlyView.
Skin tape strip lipidomic analysis revealed preexisting skin barrier lipid abnormalities at day 0 that were further exacerbated after 6 weeks of CPI treatment. Significant changes in skin (but not plasma) proinflammatory cytokines were identified in future ircAE patients after 6 weeks of CPI immunotherapy.
Taras Lyubchenko, Evgeny Berdyshev, Ryan M. Weight, Olivia Xiao, Neil J. Shah, Alina Markova, Mario E. Lacouture, Jeffrey A. Kern, Elena Goleva, Donald Y. M. Leung   +9 more
wiley   +1 more source