Results 111 to 120 of about 117,694 (268)

Hydroxyurea (hydroxycarbamide) use in adults with haemoglobin SC disease: A real‐world study in Quebec

British Journal of Haematology, EarlyView.
Summary Haemoglobin SC (HbSC) disease is the second most prevalent form of sickle cell disease, but evidence for hydroxyurea (hydroxycarbamide; HU) to prevent pain episodes was limited until the prospective identification of variables as outcomes for treatment (PIVOT) trial.
Alice Girard, Laurianne Charette, Mélissa Haouchine, Laurence Bozec, Mohamed Zakaria Bachir Bouyadjera, Mariane Poitras, Vincent‐Thierry Taillefer, Chloé Trudeau, Yves Pastore, Nathalie Letarte, Stéphanie Forté   +10 more
wiley   +1 more source

Chemoproteomic discovery of a brain‐penetrant, covalent NLRP3 inhibitor that binds a novel allosteric pocket

British Journal of Pharmacology, EarlyView.
NLRP3 is a promising inflammatory target, but existing inhibitors lack diversity and brain penetrance, and none are approved. Using chemoproteomics, we discovered a novel series that binds to Cys463 in a previously uncharacterized pocket. Compounds showed nanomolar potency, brain exposure, and in vivo suppression of IL‐1β, supporting neuroinflammatory ...
Donald C. Rogness, Evelyn P. Sievert, Vincent F. Vartabedian, Steffen M. Bernard, Erick Aitchison, William Tao, Mikaela Lindvall, Jing Qian, Christie L. Eissler, Brian E. Nordin, Benjamin D. Horning, Cian Kingston, Kelsey N. Lamb, Joshua C. Bell, Bingwen Lu, Jonathan Pollock, Jun Shi, Roli Khattri, David S. Weinstein, Matthew P. Patricelli, Brian N. Cook, Gabriel M. Simon   +21 more
wiley   +1 more source

Oncogenic BRAF and KRAS Promote Global DNA Hypomethylation Through a Directed Pathway That Upregulates TET3

Cancer Science, EarlyView.
Oncogenic BRAF and KRAS promote global DNA hypomethylation through a directed pathway that increases the levels of TET3, which helps drive tumorigenesis. ABSTRACT Aberrant epigenetic modification is one of the characteristics of the cancer genome.
Ichiro Onoyama, W. Rod Hardy, Shoichiro Takeishi, Lihua Julie Zhu, Yanglan Tan, Lloyd Hutchinson, Jianhong Ou, Leyuan Ma, Ching‐Man Virbasius, Masafumi Yasunaga, Keiichi I. Nakayama, Scott A. Shaffer, Michael R. Green   +12 more
wiley   +1 more source

KPNA2 Drives Immunosuppression in Ovarian Cancer via CCL2/CCR2‐Dependent MDSC Recruitment

Cancer Science, EarlyView.
KPNA2 drives intratumoral MDSC accumulation and immunosuppression in ovarian cancer via the NF‐κB/CCL2/CCR2 axis. Mechanistically, KPNA2 facilitates NF‐κB/p65 nuclear translocation and induces CCL2 transcription, recruiting MDSCs to establish an immunosuppressive microenvironment.
Qingli Li, Jitong Zhao, Lu Yang, Lin Li, Ce Bian, Tao Yi, Huiqiong Huang, Gang Zheng, Xiaojuan Lin   +8 more
wiley   +1 more source

Characteristics, treatment regimens, and outcomes of patients with true extramedullary multiple myeloma: a real-world monocentric analysis. [PDF]

Ann Hematol
Harzer M, Gross-Fengels N, Melzer F, Molwitz I, Kosch R, Al-Bazaz M, Artzenroth J, Cords L, Bartke L, Kamili A, Alsdorf W, Bokemeyer C, Weisel K, Leypoldt LB, Schaefers C.   +14 more
europepmc   +1 more source

High-risk genomic features predict extramedullary progression in multiple myeloma with paraskeletal plasmacytomas. [PDF]

Hemasphere
Stork M, Ondrouskova E, Mayerova J, Mareckova A, Porc JP, Reigl T, Mensikova K, Sendlerova N, Boichuk I, Cieslar J, Bilcikova M, Adam Z, Krejci M, Sandecka V, Knechtova Z, Jelinkova Z, Krticka M, Nekuda V, Rohan T, Hrabcakova V, Janska Vojtkova L, Borsky M, Radova L, Jarosova M, Pour L, Kotaskova J.   +25 more
europepmc   +1 more source

Does Visual Working Memory Decline Explain Age Differences in Visualization Performance?

Computer Graphics Forum, EarlyView.
Abstract Visualization studies that examine age effects on task performance often attribute the performance gap between young adults (YA) and people in late adulthood (PLA) to declines in cognitive abilities, especially reduced visual working memory (VWM) capacity.
Y. Li, S. Shao, P. Baudains, A. I. Meso, A. Abdul‐Rahman, R. Borgo   +5 more
wiley   +1 more source

Efficacy of Bispecific Antibodies in Relapsed or Refractory Multiple Myeloma With Extramedullary Disease: A Systematic Review and Meta-Analysis. [PDF]

Cureus
Burke OJ, Peruzzo N, Tul Ain Khan N, Kancharla P.   +3 more
europepmc   +1 more source

Advances in 4D Representation: Geometry, Motion, and Interaction

Computer Graphics Forum, EarlyView.
We survey 4D representation through three key pillars — geometry, motion, and interaction — offering a selective, representation‐centric perspective to guide researchers in choosing and customizing the right 4D representation for their tasks. Abstract We present a survey on 4D generation and reconstruction, a fast‐evolving subfield of computer graphics
M. Zhao, S. Nag, K. Wang, A. Vora, G. Ji, P. Chun, A. Mahdavi‐Amiri, H. Zhang   +7 more
wiley   +1 more source

Three Decades of Enamel Matrix Derivative: From Dental Innovation to Extra-Oral Applications. [PDF]

Int J Dent
Mercado F, Loch C, Mustafa A, Lee E, Hecker M.   +4 more
europepmc   +1 more source