Results 11 to 20 of about 117,449 (268)

NOISE-ASSISTED EMD METHODS IN ACTION

Advances in Adaptive Data Analysis, 2012
In this work we explore the capabilities of two noise-assisted EMD methods: Ensemble EMD (EEMD) and the recently proposed Complete Ensemble EMD with Adaptive Noise (CEEMDAN), to recover a pure tone embedded in different kinds of noise, both stationary and nonstationary.
Marcelo A Colominas, Gaston Schlotthauer, Patrick Flandrin   +2 more
exaly   +3 more sources

A Modified Noise-Resistant Trend Estimation Method Based on EMD and SSA for Aeroelastic Aircraft Systems [PDF]

AUT Journal of Modeling and Simulation, 2021
Aimed at the nonlinear system identification of aeroelastic aircraft, the signal decomposition methods are required to extract the contributing natural and non-standard flight modes from flight test data, especially in the presence of flight noise.
Seyed Amin Bagherzadeh, Hamed Mohammadkarimi   +1 more
doaj   +1 more source

3A-EMD: A generalized approach for monovariate and multivariate EMD [PDF]

10th International Conference on Information Science, Signal Processing and their Applications (ISSPA 2010), 2010
EMD is an emerging topic in signal processing research and is applied in various practical fields. Its recent extension to multivariate signals, motivated by the need to jointly analyze multi-channel signals, is an active topic of research. However, all the existing extensions specifically hold either mono-, bi- or tri-variate signals or require ...
Fleureau, Julien, Kachenoura, Amar, Nunes, Jean-Claude, Albera, Laurent, Senhadji, Lotfi   +4 more
openaire   +2 more sources

Avelumab internalization by human circulating immune cells is mediated by both Fc gamma receptor and PD-L1 binding

OncoImmunology, 2021
Avelumab is an IgG1 anti–programmed death ligand 1 (anti–PD-L1) monoclonal antibody that has been approved as a monotherapy for metastatic Merkel cell carcinoma and advanced urothelial carcinoma, and in combination with axitinib for advanced renal cell ...
Hulin Jin, Vittorio D'Urso, Berend Neuteboom, Sean D. McKenna, Rene Schweickhardt, Alec W. Gross, Yves Fomekong Nanfack, Andrea Paoletti, Carina Carter, Lars Toleikis, Markus Fluck, Juergen Scheuenpflug, Ti Cai   +12 more
doaj   +1 more source

Autoantibody repertoire characterization provides insight into the pathogenesis of monogenic and polygenic autoimmune diseases

Frontiers in Immunology, 2023
Autoimmune diseases vary in the magnitude and diversity of autoantibody profiles, and these differences may be a consequence of different types of breaks in tolerance.
Thomas Clarke, Pan Du, Satyendra Kumar, Shinji L. Okitsu, Mark Schuette, Qi An, Jinyang Zhang, Evgeni Tzvetkov, Mark A. Jensen, Timothy B. Niewold, Elise M. N. Ferre, Julie Nardone, Michail S. Lionakis, Jaromir Vlach, Julie DeMartino, Andrew T. Bender   +15 more
doaj   +1 more source

Risk assessment of drug–drug interaction potential for bintrafusp alfa with cytochrome P4503A4 substrates: A totality of evidence approach

Clinical and Translational Science, 2022
Bintrafusp alfa, a first‐in‐class bifunctional fusion protein composed of the extracellular domain of TGF‐βRII (a TGF‐β “trap”) fused to a human IgG1 mAb blocking PD‐L1, is being evaluated for efficacy and safety in solid tumor indications as monotherapy
Yulia Vugmeyster, George Locke, Christoph Helwig, P. Alexander Rolfe, Jennifer Q. Dong, Karthik Venkatakrishnan   +5 more
doaj   +1 more source

Identifying lupus Patient Subsets Through Immune Cell Deconvolution of Gene Expression Data in Two Atacicept Phase II Studies

ACR Open Rheumatology, 2023
Objective To use cell‐based gene signatures to identify patients with systemic lupus erythematous (SLE) in the phase II/III APRIL–SLE and phase IIb ADDRESS II trials most likely to respond to atacicept.
Matthew Studham, Cristina Vazquez‐Mateo, Eileen Samy, Philipp Haselmayer, Aida Aydemir, P. Alexander Rolfe, Joan T. Merrill, Eric F. Morand, Julie DeMartino, Amy Kao, Robert Townsend   +10 more
doaj   +1 more source

Bispecific antibodies: A guide to model informed drug discovery and development

Heliyon, 2021
Affinity (KD) optimization of monoclonal antibodies is one of the factors that impacts the stoichiometric binding and the corresponding efficacy of a drug.
Irina Kareva, Anup Zutshi, Pawan Gupta, Senthil Kabilan   +3 more
doaj   +1 more source

Preclinical evidence for the effective use of TL-895, a highly selective and potent second-generation BTK inhibitor, for the treatment of B-cell malignancies

Scientific Reports, 2023
TL-895 (formerly known as M7583) is a potent, highly selective, adenosine triphosphate (ATP)-competitive, second-generation, irreversible inhibitor of Bruton’s tyrosine kinase (BTK).
Samantha M. Goodstal, Jing Lin, Timothy Crandall, Lindsey Crowley, Andrew T. Bender, Albertina Pereira, Maria Soloviev, John S. Wesolowski, Riham Iadevaia, Sven-Eric Schelhorn, Edith Ross, Federica Morandi, Jianguo Ma, Anderson Clark   +13 more
doaj   +1 more source

NHS-IL12 and bintrafusp alfa combination therapy enhances antitumor activity in preclinical cancer models

Translational Oncology, 2022
Combinatorial immunotherapy approaches are emerging as viable cancer therapeutic strategies for improving patient responses and outcomes. This study investigated whether two such immunotherapies, with complementary mechanisms of action, could enhance ...
Chunxiao Xu, Bo Marelli, Jin Qi, Guozhong Qin, Huakui Yu, Hong Wang, Molly H. Jenkins, Kin-Ming Lo, Yan Lan   +8 more
doaj   +1 more source