Results 41 to 50 of about 117,449 (268)

On the Memory Cost of EMD Algorithm

IEEE Access, 2022
Empirical mode decomposition (EMD) and its variants are adaptive algorithms that decompose a time series into a few oscillation components called intrinsic mode functions (IMFs). They are powerful signal processing tools and have been successfully applied in many applications.
Hsu-Wen Vincent Young, Yu-Chuan Lin, Yung-Hung Wang   +2 more
openaire   +2 more sources

Frontal chromatography purification of monoclonal antibodies with high loadings using a cation exchange hydrogel membrane

Journal of Chromatography Open
The application of frontal chromatography with cation exchange (CEX) resins to the downstream polishing of therapeutic monoclonal antibodies (mAbs) enables the selective removal of impurities, such as mAb aggregates and host cell proteins, with very high
Amit K. Dutta, Ariana Ly, Amro M. Elbakri, Vivian Pham, Brett S. Schroyer, Sean L. Foley, Philip M. Goddard, Kevin S. Rautio, Matthew T. Stone   +8 more
doaj   +1 more source

Temporal and spatial adaptation of transient responses to local features

Frontiers in Neural Circuits, 2012
Interpreting visual motion within the natural environment is a challenging task, particularly considering that natural scenes vary enormously in brightness, contrast and spatial structure.
David C O'Carroll, Paul eBarnett, Karin eNordström, Karin eNordström   +3 more
doaj   +1 more source

Update on the psychometric properties and minimal important difference (MID) thresholds of the FACT-M questionnaire for use in treatment-naïve and previously treated patients with metastatic Merkel cell carcinoma

Health and Quality of Life Outcomes, 2020
Objectives For valid and reliable assessment of patients’ Health-Related Quality of Life (HRQoL), it is crucial to use psychometrically robust instruments.
Murtuza Bharmal, Sandra Nolte, Mickaël Henry-Szatkowski, Meliessa Hennessy, Michael Schlichting   +4 more
doaj   +1 more source

Pharmacometric modeling and machine learning analyses of prognostic and predictive factors in the JAVELIN Gastric 100 phase III trial of avelumab

CPT: Pharmacometrics & Systems Pharmacology, 2022
Avelumab (anti–PD‐L1) is an approved anticancer treatment for several indications. The JAVELIN Gastric 100 phase III trial did not meet its primary objective of demonstrating superior overall survival (OS) with avelumab maintenance versus continued ...
Nadia Terranova, Jonathan French, Haiqing Dai, Matthew Wiens, Akash Khandelwal, Ana Ruiz‐Garcia, Juliane Manitz, Anja vonHeydebreck, Mary Ruisi, Kevin Chin, Pascal Girard, Karthik Venkatakrishnan   +11 more
doaj   +1 more source

Audio coding via EMD

Digital Signal Processing, 2020
Abstract In this paper an audio coding scheme based on the empirical mode decomposition in association with a psychoacoustic model is presented. The principle of the method consists in breaking down adaptively the audio signal into intrinsic oscillatory components, called Intrinsic Mode Functions (IMFs), that are fully described by their local ...
Abdel-Ouahab Boudraa, Kais Khaldi, Thierry Chonavel, Monia Turki-Hadj Alouane, Ali Komaty   +4 more
openaire   +4 more sources

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Matrix metalloproteinase‐9 regulates cell adhesion and membrane protrusive activity of ovarian cancer cells

FEBS Open Bio, EarlyView.
Matrix metalloproteinase‐9 (MMP9) drives ovarian cancer progression. Using MMP9‐null cells (M9‐KO) created from ovarian cancer cells, we found MMP9 loss did not block Epidermal Growth Factor (EGF)‐driven E‐cadherin dissolution or EMT but delayed and reduced EGF‐driven membrane protrusions. Transient MMP9 re‐expression drove membrane protrusion.
Claire Strauel, Sam Bennett, Natalie Ehlinger, Nelson Cook, Katelyn Marvin, Caleb L. Lines, Sam Reyes, Brooke Kirby, Shawn M. Ellerbroek   +8 more
wiley   +1 more source

Iron homeostasis disruption and lipid peroxidation in skeletal muscle during short‐term immobilization

FEBS Open Bio, EarlyView.
14‐day casting‐induced immobilization reduced gastrocnemius muscle mass and increased non‐heme iron and ferritin heavy chain levels. Despite iron accumulation, transferrin receptor 1 and iron regulatory protein 2 were paradoxically upregulated. Lipid peroxidation was elevated without compensatory antioxidant responses.
Haruka Yokogawa, Kazuhiko Higashida, Naoya Nakai   +2 more
wiley   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source