Targeted protein degradation in oncology: novel therapeutic opportunity for solid tumours?
Molecular Oncology, EarlyView.Current anticancer therapies are limited by the occurrence of resistance and undruggability of most proteins. Targeted protein degraders are novel, promising agents that trigger the selective degradation of previously undruggable proteins through the recruitment of the ubiquitin–proteasome machinery. Their mechanism of action raises exciting challenges,
Noé Herbel, Sophie Postel‐Vinay
wiley +1 more source
Epidemiology of the Systemic Inflammatory Response Syndrome (SIRS) in the Emergency Department
Western Journal of Emergency Medicine, 2014 Introduction: Consensus guidelines recommend sepsis screening for adults with systemic inflammatory response syndrome (SIRS), but the epidemiology of SIRS among adult emergency department (ED) patients is poorly understood.
Timothy Horeczko +2 more
doaj +1 more source
An Alternative Formulation of Coxian Phase-type Distributions with Covariates: Application to Emergency Department Length of Stay [PDF]
arXiv, 2019 In this paper we present a new methodology to model patient transitions and length of stay in the emergency department using a series of conditional Coxian phase-type distributions, with covariates. We reformulate the Coxian models (standard Coxian, Coxian with multiple absorbing states, joint Coxian, and conditional Coxian) to take into account ...
arxiv
Evaluation of Current Emergency Department Fall Risk Assessment Tools: Is An Emergency Department Specific Fall Risk Assessment Tool Needed? [PDF]
, 2017 Problem: The ability to accurately and quickly identify patients at high risk for falls at the point of entry into the emergency department is the most important step in fall prevention and avoiding harm.
Brown, Carrie A.
core +1 more source
Access to primary care and the route of emergency admission to hospital: retrospective analysis of national hospital administrative data [PDF]
, 2015 BACKGROUND: The UK government is pursuing policies to improve primary care access, as many patients visit accident and emergency (A and E) departments after being unable to get suitable general practice appointments.
Bottle, A +8 more
core +3 more sources
Systematic profiling of cancer‐fibroblast interactions reveals drug combinations in ovarian cancer
Molecular Oncology, EarlyView.Fibroblasts, cells in the tumor environment, support ovarian cancer cell growth and alter morphology and drug response. We used fibroblast and cancer cell co‐culture models to test 528 drugs and discovered new drugs for combination treatment. We showed that adding Vorinostat or Birinapant to standard chemotherapy may improve drug response, suggesting ...
Greta Gudoityte +10 more
wiley +1 more source
Western Journal of Emergency Medicine, 2014 Introduction: National guidelines suggest that most skin abscesses do not require antibiotics, and that cellulitis antibiotics should target streptococci, not community-associated MRSA (CA-MRSA).
Daniel J. Pallin +2 more
doaj +1 more source
Emergence and Synchronization in Chaotic Oscillators and in the Human Cortical Network [PDF]
arXiv, 2021 When we look at the world around us, we see complex physical systems and emergent phenomena. Emergence occurs when a system is observed to have properties that its parts do not have on their own. These properties or behaviors emerge only when the parts interact in a wider whole. Examples of emergence can vary from the synchronization of pendulum clocks
arxiv
Wireless E911 Emergency Communications Fund Iowa Homeland Security and Emergency Management Division of the Iowa Department of Public Defense independent auditor's reports, basic financial statements and supplementary information, June 30, 2009. [PDF]
, 2010 Audit report on the Wireless E911 Emergency Communication Fund of the Iowa Homeland Security and Emergency Management Division of the Iowa Department of Public Defense for the year ended June 30 ...
core
Ultrasound by emergency physicians to detect abdominal aortic aneurysms: a UK case series [PDF]
, 2004 Early identification of abdominal aortic aneurysms in some patients can be difficult and the diagnosis is missed in up to 30% of patients. Ultrasound cannot be used to identify a leak, but the presence of an aneurysm in an unstable patient is ...
Brenchley, J. +4 more
core +2 more sources