Results 51 to 60 of about 1,650,458 (302)

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Greening Multi-Tenant Data Center Demand Response [PDF]

, 2015
Data centers have emerged as promising resources for demand response, particularly for emergency demand response (EDR), which saves the power grid from incurring blackouts during emergency situations.
Chen, Niangjun, Ren, Shaolei, Ren, Xiaoqi, Wierman, Adam   +3 more
core   +3 more sources

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Ensuring the continuity of essential health services during mpox response in the African region

Journal of Public Health in Africa
N ...
Miriam Nanyunja, Viviane Fossouo, Ebenezer Obi Daniel, Joseph C. Okeibunor, Samuel Boland, Hilary K. Njenge, Brice W. Bicaba, Otim P.C. Ramadan, Solomon F. Woldetsadik, Dick D. Chamla, Fiona Braka, Abdou S. Gueye   +11 more
doaj   +1 more source

Most Say Disaster Spending Does Not Require Offsetting Cuts: A Pew Research Center/Washington Post Survey [PDF]

, 2013
As Oklahoma recovers from severe damage caused by last week's tornado, a majority of Americans (59%) say federal spending in response to natural disasters is emergency aid that does not need to be offset by cuts to other programs, while 29% say such ...
Alec Tyson, Carroll Doherty, Michael Dimock   +2 more
core  

Ambulance Emergency Response Optimization in Developing Countries

, 2019
The lack of emergency medical transportation is viewed as the main barrier to the access of emergency medical care in low and middle-income countries (LMICs).
Boutilier, Justin J., Chan, Timothy C. Y.   +1 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gabor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Modeling emergency management data by UML as an extension of geographic data sharing model: AST approach [PDF]

, 2009
Applying GIS functionality provides a powerful decision support in various application areas and the basis to integrate policies directed to citizens, business, and governments.
Aydinoglu, Arif Cagdas, Dilo, Arta, Quak, Wilko, Yomralioglu, Tashin   +3 more
core   +1 more source