Results 61 to 70 of about 6,320,379 (300)

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Construction of an coordinated regional infectious disease emergency command and operation platform in Zhejiang province

Zhongguo gonggong weisheng
To implement the national Center for Disease Control and Prevention’s mandate for the development of provincially coordinated regional infectious disease emergency command and operation platforms and to enhance the efficiency and command capabilities of ...
Renjie ZHANG, Zhen WANG, Xiaopeng SHANG, Tao JIANG, Biyao LIU, Qiao BIAN, Zhen JIANG   +6 more
doaj   +1 more source

The Study of Utilization and Regulations of the Deep Web

Zhishi guanli luntan, 2016
[Purpose/significance] The “deep web” encrypts information for privacy protection, but it was used by IS terrorists to launch attacks in Paris. Except for analyzing the utilization and regulations of the “deep web”, this paper also analyzes its detriment
Zhao Zhiyun, Zhang Xu, Zhiyun1 Zhang Xu1 Luo Zheng, Yuan Weiping
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Research on Carbon Emission Accounting and the "Dual Carbon" Transformation Path of Industrial Parks

南方能源建设
[Introduction] As an important carrier of China's industrialization and urbanization, industrial parks not only provide a large amount of infrastructure and public services, but also become the main source of carbon emission in China and an important ...
Zhong WANG, Siming MA, Tingting WANG, Wei TAO, Jing XU   +4 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Other title: CT business and facility required reporting guidance : EPCRA law and regulations; Other title: Guidance for CT business and facility, required reporting under EPCRA law and regulations

, 2011
Updated Nov. 2011.; Previously published: Right-to-know compliance guidance . [Hartford] : Connecticut State Emergency Response Commission : Connecticut Dept. of Environmental Protection, [2008]

core   +1 more source

Meta-analysis of hybrid immunity to mitigate the risk of Omicron variant reinfection

Frontiers in Public Health
BackgroundHybrid immunity (a combination of natural and vaccine-induced immunity) provides additional immune protection against the coronavirus disease 2019 (COVID-19) reinfection.
Huiling Zheng, Huiling Zheng, Shenggen Wu, Wu Chen, Shaojian Cai, Meirong Zhan, Cailin Chen, Jiawei Lin, Zhonghang Xie, Jianming Ou, Wenjing Ye   +10 more
doaj   +1 more source