Results 61 to 70 of about 570,548 (262)
Molecular Oncology, EarlyView.RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner +14 more
wiley +1 more source
BMJ Public HealthMalawi—one of the low-income countries in Africa—has witnessed a series of flood-related disasters in many years. The recent tropical cyclone Freddy (TCF) has indispensable effects on the unequal distribution of the social determinants of health with ...
Joseph Okeibunor +12 more
doaj +1 more source
Molecular Oncology, EarlyView.CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Molecular Oncology, EarlyView.Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou +12 more
wiley +1 more source
Zhongguo gonggong weishengTo implement the national Center for Disease Control and Prevention’s mandate for the development of provincially coordinated regional infectious disease emergency command and operation platforms and to enhance the efficiency and command capabilities of ...
Renjie ZHANG +6 more
doaj +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Meta-analysis of hybrid immunity to mitigate the risk of Omicron variant reinfection
Frontiers in Public HealthBackgroundHybrid immunity (a combination of natural and vaccine-induced immunity) provides additional immune protection against the coronavirus disease 2019 (COVID-19) reinfection.
Huiling Zheng +10 more
doaj +1 more source
The exploration and thinking of the application of Go language on domestic CPU platform
Dianzi Jishu Yingyong, 2018 The Go language, which represents the new age of information, has a high degree of concurrency for server programming, and has natural cross-platform advantage, which reduces the difficulty of developing distributed heterogeneous computing platforms, and
Chen Xi, Hu Bin
doaj +1 more source
Emerging Powers, Emerging Markets, Emerging Societies: Global Responses [PDF]
, 2016 In Chapter 1, we presented our understanding of the “great transformations” taking place in international relations and in the international political economy. These transformations are also creating responses at national level in terms of economic/market orientation, political alliance, development strategy, and so on. One of the book’s key objectives
Christensen, Steen Fryba, Li, Xing
openaire +1 more source