Results 51 to 60 of about 570,548 (262)

Ensuring the continuity of essential health services during mpox response in the African region

Journal of Public Health in Africa
N ...
Miriam Nanyunja, Viviane Fossouo, Ebenezer Obi Daniel, Joseph C. Okeibunor, Samuel Boland, Hilary K. Njenge, Brice W. Bicaba, Otim P.C. Ramadan, Solomon F. Woldetsadik, Dick D. Chamla, Fiona Braka, Abdou S. Gueye   +11 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Evaluation of the epidemic intelligence from open sources (EIOS) system for the early detection of outbreaks and health emergencies in the African region

BMC Public Health
Introduction Public health today is challenged by a wide array of hazards that threaten humans, often resulting in high rates of morbidity and mortality when they strike. These events should be detected and responded to as early as possible to save lives
George Sie Williams, Etien Luc Koua, Philip Abdelmalik, Freddy Kambale, Emerencienne Kibangou, Joyce Nguna, Charles Okot, Godwin Akpan, Fleury Moussana, Jean Paul Kimenyi, Ramazani Zaza, Raquel Medialdea Carerra, Yasmin Rabiyan, Mark Woolhouse, Joseph Okeibunor, Abdou Salam Gueye   +15 more
doaj   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Research and Application of Functional Model Construction Method for Production Equipment Operation Management and Control Oriented to Diversified and Personalized Scenarios

Machines
As complex system engineering involving multiple stakeholders, multi-objective collaboration, and multi-spatiotemporal scales, the components, logical structure, and functional mechanisms of production equipment operation management and control (PEOMC ...
Jun Li, Keqin Dou, Jinsong Liu, Qing Li, Yong Zhou   +4 more
doaj   +1 more source

Variability in the inorganic composition of colored acrylonitrile–butadiene–styrene and polylactic acid filaments used in 3D printing

SN Applied Sciences, 2022
Fused filament fabrication is a 3D printing technique that has gained widespread use from homes to schools to workplaces. Thermoplastic filaments, such as acrylonitrile–butadiene–styrene (ABS) and polylactic acid (PLA), are extruded at temperatures near ...
Derek M. Peloquin, Logan N. Rand, Eric J. Baumann, Ali Gitipour, Joanna Matheson, Todd P. Luxton   +5 more
doaj   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source