Results 101 to 110 of about 631,916 (299)
Designing towards the Unknown: Engaging with Material and Aesthetic Uncertainty
Informatics, 2017 New materials with new capabilities demand new ways of approaching design. Destabilising existing methods is crucial to develop new methods. Yet, radical destabilisation—where outcomes remain unknown long enough that new discoveries become possible—is ...
Danielle Wilde, Jenny Underwood
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In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
FEBS Letters, EarlyView.We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source
Emergent digital possibilities for design-led reuse within circular economy
npj Urban SustainabilityThis paper discusses literature and practice-based case studies in transformative, design-led reuse using emerging technologies. The inability of recycling to manage the assortment and complexity of waste materials within Circular Economy (CE) demands ...
Guy Keulemans, Roxane Adams
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She Ji: The Journal of Design, Economics and InnovationSince at least the mid-1980s, design has been dominated by a human-centered and user-centered paradigm. Currently, the implications of technological and environmental transformations are challenging designers to focus on complex socio-technical systems ...
Laura Forlano
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Play in the city: Parkour and architecture [PDF]
, 2011 The ability to play freely in our cities is essential for sustainable wellbeing. When integrated successfully into our cities, Urban Play performs an important role; physically, socially and culturally contributing to the image of the city.
Guaralda, Mirko, Rawlinson, Christopher
core +1 more source
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Analysis of Dynamic Task Allocation in Multi-Robot Systems
, 2006 Dynamic task allocation is an essential requirement for multi-robot systems operating in unknown dynamic environments. It allows robots to change their behavior in response to environmental changes or actions of other robots in order to improve overall ...
Galstyan, Aram +3 more
core +5 more sources
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Metrópolis: un juego serio emergente en una ciudad inteligente
Dyna, 2019 Emerging serious games mark the beginning of a new era in video games. Emerging serious games introduce advances in distributed artificial intelligence into their design in order to guide the player’s manipulation of a specific subject in an adaptive way.
Jose Aguilar +5 more
doaj +1 more source
Emergent Form from Structural Optimisation of the Voronoi Polyhedra Structure [PDF]
, 2007 In the course of the exploration of computational means in the architectural design process, in order to investigate more complex, adaptive geometries, the Voronoi diagram has recently gained some attention, being a three-dimensional space-filling ...
Derix, C, Friedrich, E, Hanna, S
core