Results 111 to 120 of about 631,916 (299)
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
TechnologiesVideo games, as interactive artifacts within the continuum of information and communication technology (ICT), encapsulate an ontological inquiry: which mechanism maintains user engagement while evolving with ICT-driven innovations?
Mengfan Zou +3 more
doaj +1 more source
Structure Design and Deflection Analysis of the New Large Deflection Lamina Emergent Joints
Jixie chuandong, 2022 Two kinds of large deflection plane folding hinges, named OSD-LEJ (outside-series-deployed lamina emergent joint) and IOSD-LEJ (inverted-outside-series-deployed lamina emergent joint), are designed with flexible segments arranged in series on the outside,
Liu Qingling
doaj
Emergent design principles for prediction algorithms in health care. [PDF]
Heart Rhythm, 2020 Wheelock K, Lee JM, Ghanbari H.
europepmc +1 more source
Topology of Networks in Generalized Musical Spaces [PDF]
, 2019 The abstraction of musical structures (notes, melodies, chords, harmonic or rhythmic progressions, etc.) as mathematical objects in a geometrical space is one of the great accomplishments of contemporary music theory.
Nardelli, Marco Buongiorno
core +1 more source
FEBS Letters, EarlyView.Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley +1 more source
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
No free lunch for avoiding clustering vulnerabilities in distributed systems
Scientific ReportsEmergent design failures are ubiquitous in complex systems, and often arise when system elements cluster. Approaches to systematically reduce clustering could improve a design’s resilience, but reducing clustering is difficult if it is driven by ...
Pheerawich Chitnelawong +4 more
doaj +1 more source