Results 51 to 60 of about 133,089 (241)
Frontiers in Neuroscience, 2018 Sonification is an open-ended design task to construct sound informing a listener of data. Understanding application context is critical for shaping design requirements for data translation into sound.
Insook Choi
doaj +1 more source
Time after time – circadian clocks through the lens of oscillator theory
FEBS Letters, EarlyView.Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo +2 more
wiley +1 more source
Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions
FEBS Letters, EarlyView.Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf +6 more
wiley +1 more source
PENELITIAN BUDAYA HUKUM:KONSEP DAN METODOLOGI
Masalah-Masalah Hukum, 2014 This paper discusses the coherence between the concepts and methods of the legal culture study according to the ideational approach of anthropological perspective, and operational examples presented through techniques to formulate the problem in ...
Teddy Asmara
doaj +1 more source
Emergence in design science research
, 2020 Designing artifacts is a pivotal activity in Information Systems (IS) research. Beside the development process, the evaluation of artifacts is important as it allows the application of scientific methodologies to generate and accumulate knowledge. Commonly, the evaluation of an artifact is conducted in terms of the artifacts usefulness, utility or ...
Klesel, Michael, Henseler, Jörg
openaire +3 more sources
Designing with Emerging Science
32nd Australian Conference on Human-Computer Interaction, 2020 The emerging science of the “gut-brain axis” has been used as the basis for self-tracking technologies assuming that this connection can be used productively for better regulating mood, supporting digestive health, and avoiding disease. Taking this emerging science as a source of design inspiration, this paper presents a design research process to ...
Jenkins, Tom +4 more
openaire +2 more sources
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
Engaging Science, Technology, and Society, 2017 Game design offers a powerful pedagogical paradigm for engaging students in thinking and researching sociotechnical systems. Using the example of designing a game around fracking, this paper describes how game design grapples with emergent dynamic ...
Joseph Dumit
doaj +1 more source
Design of an emergency footbridge
WIT Transactions on The Built Environment, 2014 This paper will describe the design of a temporary emergency floating footbridge, to be made when the infrastructure is destroyed by a flood, hurricane, tsunami or any other disaster. The bridge is made of identical floating modules. The modules are composed of prefabricated elements: two trusses, a pontoon and the footpath.
Rihal, S. (author) +1 more
openaire +3 more sources
FEBS Letters, EarlyView.Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman +2 more
wiley +1 more source