Results 101 to 110 of about 3,481 (299)

Mental Causation and Intelligibility

open access: yesHumana.Mente: Journal of Philosophical Studies, 2015
I look at some central positions in the mental causation debate – reductionism, emergentism, and nonreductive physicalism – on the hypothesis that mental causation is intelligible.
David Robb
doaj  

What Makes a Computation Unconventional?

open access: yes, 2013
A coherent mathematical overview of computation and its generalisations is described. This conceptual framework is sufficient to comfortably host a wide range of contemporary thinking on embodied computation and its models.Comment: Based on an invited ...
Cooper, S. Barry
core   +1 more source

One size does not fit all: An in vitro evaluation of the effects of bezafibrate and medroxyprogesterone acetate on human SH‐SY5Y and U‐87 MG cancer cells

open access: yesFEBS Open Bio, EarlyView.
Drugs previously repurposed to target blood cancers reduced neuroblastoma and glioblastoma cell growth and viability. However, their levels of anticancer activity were different and their clinical application may be problematic due to side effects at effective doses.
Abhishek Kharawatkar   +4 more
wiley   +1 more source

PHILOSOPHY OF MIND; THEORETICAL AND EXPERIMENTAL CONTRIBUTION TO THE EMERGING VISION OF MIND-BRAIN INTERACTION.

open access: yesCuadernos de Neuropsicología, 2011
This work aims to contribute to the discussion of mind-brain interactions from an emergentism point of view of the Philosophy of Mind, using some of the naturalized theories.
Paul Ruiz Santos
doaj  

Leis, causas e poderes

open access: yesPrincipia: An International Journal of Epistemology, 2019
This paper deals with the notions of scientific law, natural causes, and the powers of causes to produce their effects from the point of view of perspectival realism. In the first section I deal with the conception of cause defended by George H.
Luiz Henrique de A. Dutra
doaj   +1 more source

Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment

open access: yesAging and Cancer, EarlyView.
Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey   +12 more
wiley   +1 more source

Prognostic Impact of European LeukemiaNet Genetic Risk Stratification System in Adult Patients With Acute Myeloid Leukemia

open access: yesAging and Cancer, EarlyView.
This study aimed to evaluate the prognostic value of ELN2017 in predicting survival outcomes and to assess the impact of clinical and molecular factors such as age, FLT3 and NPM1 mutations, and allogeneic hematopoietic stem cell transplantation (allo‐HSCT).
Mobina Shrestha   +4 more
wiley   +1 more source

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

open access: yesAging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang   +3 more
wiley   +1 more source

Fluid and Neuroimaging Biomarkers in Microgliopathy Colony‐Stimulating Factor‐1 Receptor‐Related Disorders

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective This study aims to identify both fluid and neuroimaging biomarkers for CSF1R‐RD that can inform the optimal timing of treatment administration to maximize therapeutic benefit, while also providing sensitive quantitative measurements to monitor disease progression.
Tomasz Chmiela   +13 more
wiley   +1 more source

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