Results 81 to 90 of about 3,481 (299)

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

open access: yesMolecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner   +14 more
wiley   +1 more source

Quantum, consciousness and panpsychism: a solution to the hard problem [PDF]

open access: yes, 2004
We analyze the results and implications of the combination of quantum and consciousness in terms of the recent QSC analysis. The quantum effect of consciousness is first explored. We show that the consciousness of the observer can help to distinguish the
Gao, Mr Shan
core  

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

open access: yesMolecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak   +10 more
wiley   +1 more source

«Land of Confusion»: Quantum Physic In IR Theory?

open access: yesVestnik MGIMO-Universiteta, 2016
The article deals with the "Quantum mind"hypothesis which has been elaborated in recent works of Alexander Wendt. It is ultimately significant to analyze this hypothesis and to expand on its difficulties and possible inconsistencies given Wendt's ...
Tatiana A. Alekseeva   +2 more
doaj   +2 more sources

Emergence and Downward Causation Reconsidered in Terms of the Aristotelian-Thomistic View of Causation and Divine Action

open access: yesScientia et Fides, 2016
One of the main challenges of the nonreductionist approach to complex structures and phenomena in philosophy of biology is its defense of the plausibility of the theory of emergence and downward causation.
Mariusz Tabaczek
doaj   +1 more source

Dewey’s Notion of Aesthetic Experience. A Comparative Approach [PDF]

open access: yes, 2015
This presentation attempts to contribute the nature and scope of Dewey’s aesthetic, through a comparative methodology, which brings Deweyan notion of aesthetic experience into dialogue with the concept of harmony that Confucian philosophy suggests. Thus,
Luque, Gloria
core  

Causation at different levels : Tracking the commitments of mechanistic explanations [PDF]

open access: yes, 2011
This paper tracks the commitments of mechanistic explanations focusing on the relation between activities at different levels. It is pointed out that the mechanistic approach is inherently committed to identifying causal connections at higher levels with
Fazekas, Péter
core   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

open access: yesMolecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena   +15 more
wiley   +1 more source

The mind-body problem; three equations and one solution represented by immaterial-material data [PDF]

open access: yes, 2018
Human life occurs within a complex bio-psycho-social milieu, a heterogeneous system that is integrated by multiple bidirectional interrelations existing between the abstract-intangible ideas and physical-chemical support of environment.
Motofei, Ion G., Rowland, David L.
core   +1 more source

Checkpoint blockade and the stem‐like T cell trade‐off

open access: yesMolecular Oncology, EarlyView.
Stem‐like T cells are key to the success of programmed cell death protein 1 (PD1) blockade, as they sustain long‐term anti‐tumor response by continuously generating effector CD8+ T cells. However, how these cells are maintained in cancer is not fully understood. Hor et al.
Julie M. Mazet, Johanna A. Joyce
wiley   +1 more source

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