Results 71 to 80 of about 394 (257)
The foundational crisis of cognitive science: challenging the emergentist challenge
Revista de Filosofia, 2010 The following pages contend that, in spite of its intensive development, contemporary cognitive science has recently entered a phase of fairly acute uncertainty and confusion regarding some of its most essential foundations. They emphasize two aspects of
Jean-Michel Roy
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Molecular Oncology, EarlyView.Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou +12 more
wiley +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Enfermedades emergentes y re-emergentes
Revista de la Facultad de Medicina, 1996 Ante el surgimiento del Virus de la Inmunodeficiencia Humana, HIV, del Síndrome de la Inmuno Deficiencia Adquirida, SIDA, y del mortal virus del Ebola, que azotó al Zaire durante el año de 1995, el Instituto de Medicina de los Estados Unidos de América constituyo el Comité de Amenazas Microbianas Emergentes para la Salud, conformado por especialistas ...
openaire +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Mental Causation and Intelligibility
Humana.Mente: Journal of Philosophical Studies, 2015 I look at some central positions in the mental causation debate – reductionism, emergentism, and nonreductive physicalism – on the hypothesis that mental causation is intelligible.
David Robb
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Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Cuadernos de Neuropsicología, 2011 This work aims to contribute to the discussion of mind-brain interactions from an emergentism point of view of the Philosophy of Mind, using some of the naturalized theories.
Paul Ruiz Santos
doaj
Value Creation in Business Models is Based on Intellectual Capital – and Only Intellectual Capital!
Journal of Business Models, 2019 This chapter applies the lens of emergentism and emergent properties to the understanding of value propositions, value creation, value delivery and value realization.
Christian Nielsen, Henrik Dane-Nielsen
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Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source