Results 61 to 70 of about 933 (281)

ESR1 methylation and ESR1 mutations in circulating tumor cells (CTCs) and paired plasma‐cfDNA of advanced breast cancer patients: A feasibility proof‐of‐concept study

open access: yesMolecular Oncology, EarlyView.
Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou   +12 more
wiley   +1 more source

Emergencja duszy. Andreasa Nordlandera odczytanie potencjalizmu św. Augustyna i kwestia stworzenia duszy ludzkiej w ewoluującym wszechświecie

open access: yesStudia Philosophiae Christianae
This article takes up the question of the creation of the human soul in the context of evolution, using St. Augustine’s interpretive framework.
Tomasz Maziarka
doaj   +1 more source

Tecnologías emergentes, ¿pedagogías emergentes?

open access: yes, 2012
Adell, J. y Castañeda, L. (2012). Tecnologías emergentes, ¿pedagogías emergentes? En J. Hernández, M. Pennesi, D. Sobrino y A. Vázquez (coord.). Tendencias emergentes en educación con TIC. Barcelona: Asociación Espiral, Educación y Tecnología. págs. 13-32.
Adell, Jordi   +1 more
openaire   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska   +13 more
wiley   +1 more source

Theology and Naturalism

open access: yesSt Andrews Encyclopaedia of Theology, 2023
Historically and today, the movement of naturalism affirms the reality of the natural world, rejecting religious views of God, the soul, and values when these are understood to be supernatural or transcending the natural world.
Charles Taliaferro
doaj  

The Interaction of Noetic and Psychosomatic Operations in a Thomist Hylomorphic Anthropology

open access: yesScientia et Fides, 2018
This article, the second of a two-part essay, outlines a solution to certain tensions in Thomist philosophical anthropology concerning the interaction of the human person’s immaterial intellectual or noetic operations with the psychosomatic sensory ...
Daniel De Haan
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

open access: yesMolecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober   +16 more
wiley   +1 more source

Cartesian Libertarianism: "Intrinsic Autonomy" and the need for Other-Worldly Substance [PDF]

open access: yesPizhūhish/hā-yi Falsafī- Kalāmī
Contemporary discussions on freedom have recently drawn attention to the implications the mind-body relation.Contemporary discussions on freedom have recently drawn attention to the implications of the mind-body relation.
Joshua Farris
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

«LAND OF CONFUSION»: QUANTUM PHYSICS IN IR THEORY?

open access: yesVestnik MGIMO-Universiteta, 2016
The article deals with the "Quantum mind"hypothesis which has been elaborated in recent works of Alexander Wendt. It is ultimately significant to analyze this hypothesis and to expand on its difficulties and possible inconsistencies given Wendt's ...
T. A. Alekseeva   +2 more
doaj   +1 more source

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