Results 91 to 100 of about 2,119,073 (289)
Targeting the NR1D1–IGF2BP2–V‐ATPase Axis With Hybrid Nanovesicles Restores Macrophage Rhythms to Reverse Sepsis‐Induced Immunosuppression
Advanced Science, EarlyView.Sepsis disrupts immune‐cell rhythms and weakens bacterial clearance. Biomimetic nanovesicles combining erythrocyte and inflammation‐activated macrophage membranes deliver siNR1D1 to dysfunctional macrophages, restoring the NR1D1–IGF2BP2–V‐ATPase pathway, circadian regulation, phagolysosomal acidification, and antimicrobial defense.Lang Chen, Wenyi Lin, Lang Jiang, Xuehui Gao, Chenyan Yu, Jili Han, Zhenping Liu, Xuefeng Li, Mei He, Chang Li, Qilan Li, Chaoying Song, Jiqian Xu, You Shang +13 morewiley +1 more sourceGlycobiology of Human Fungal Pathogens: New Avenues for Drug Development
, 2019 Invasive fungal infections (IFI) are an increasing threat to the developing world, with fungal spores being ubiquitous and inhaled every day. Some fungal species are commensal organisms that are part of the normal human microbiota, and, as such, do not ...Lee, Danielle J, Thomas Haselhorst, Danielle J. Lee, Haselhorst, Thomas, Françoise H. Routier, Holly O’Donnell, Tiralongo, Joe, Routier, Francoise H, Joe Tiralongo, O'Donnell, Holly +9 morecore +1 more sourceGenome analysis of the necrotrophic fungal pathogens Sclerotinia sclerotiorum and Botrytis cinerea [PDF]
, 2011 Sclerotinia sclerotiorum and Botrytis cinerea are closely related necrotrophic plant pathogenic fungi notable for their wide host ranges and environmental persistence.Giraud-Delville, Corinne, Grossetete, S., Jérome Collémare, de Vries, Ronald P., Kohn, L., Cuomo, CA, Poulain, J., Simon, A, Quévillon, E., Henrissat, B., Howlett, BJ., Yarden, O., Nicholas J Talbot, Howlett, BJ, Poussereau, Nathalie, Beever, Ross E., Kretschmer, M., Howlett, Barbara J., Poussereau, N, Templeton, M, Sexton, Adrienne, Kodira, Chinnappa, Dyer, P., Patrick Wincker, Sirven, C, Da Silva, C., Jeffrey A Rollins, Rascle, Christine, Amir Sharon, Kodira, C., Talbot, N.J., Have, A, Ross E. Beever, Danchin, EG, Silva, C., Da, Qu��villon, Emmanuel, Howlett, B., Dickman, Marty, Tatiana Giraud, Linda Kohn, Fournier, E., Lebrun, MH, Mauceli, E, Tudzynski, Paul, Joelle Amselem, Kim M. Plummer, Anthouard, Véronique, Amselem, Joelle,, Plummer, Kim M., Güldener, Ulrich, Julia Schumacher, Lappartient, Anne, ten Have, Arjen, Mathias Choquer, Poulain, Julie, Brault, B, Beffa, Rolland, Mauceli, Evan, Rolland Beffa, Pearson, M, Yandava, C., Cécile Neuvéglise, Danchin, E., Pedro M Coutinho, Neuvéglise, C, Sirven, C., Ross E Beever, Chandri Yandava, Gautier, A, Cuomo, C., Bouzid, O, Marion Andrew, Christina A. Cuomo, Brault, B., Soanes, Darren M., Hahn, M., Choquer, M., Ernesto P Benito, Gautier, Angelique, Amselem, Joelle, J., Andrew, M., Barbara J. Howlett, Yandava, Chandri, Beever, R., Cuomo, C.A., Marc-Henri Lebrun, Soanes, D.M., Giraud, C., Howlett, B.J., Yarden, Oded, Gonzalez, C, Templeton, M., Sabine Fillinger, Matthias Kretschmer, Elisabeth Fournier, Gout, L., Nicolas Lapalu, Hahn, Matthias, Lebrun, Marc-Henri, Ernesto P. Benito, Couloux, A, Dickman, M, Corinne Da Silva, Lappartient, A., Caroline Levis, Viaud, M., Tudzynski, Bettina, Benoit, I, Gautier, A., van Kan, JAL, Choquer, M, van Kan, Jan A. L., Lapalu, N., Richardson, Paul M., Beever, RE, Giraud, Corinne, van Kan, J., Silva, E, Plummer, K.M., Viaud, Muriel,, Darren M. Soanes, Coutinho, Pedro, M, Kretschmer, M, Güldener, U, Vries, R.P., de, Kim M Plummer, ten Have, A., Talbot, Nicholas J., Hadi Quesneville, van Kan, J.A., Quévillon, E, Dyer, PS, Sexton, A, Coutinho, P.M., Coll��mare, J��rome, Sharon, A, Anthouard, V., Lappartient, A, Quesneville, H., Bouzid, O., Marty Dickman, Rollins, JA, Wincker, P., Giraud, Tatiana, Giraud, T., Paul S. Dyer, Soanes, DM, Templeton, Matt, Nicholas J. Talbot, Ségurens, B., Schumacher, J., Andrew, M, Choquer, Mathias, Grossetete, S, Levis, C., Silva, E.I.L., Beffa, R, Sandrine Grossetete, Michaela Leroch, Quesneville, H, Coutinho, Pedro M., Kohn, Linda, Andrew, Marion, Viaud, M, Pedro M. Coutinho, Zehua Chen, Collemare, Jerome, Segurens, Béatrice, Plummer, K., Viaud, Muriel, Rascle, C, Couloux, Arnaud, Levis, C, Matthias Hahn, Talbot, NJ, Henrissat, Bernard, Cuomo, Christina A., Tudzynski, B., Pradier, JM, Jean-Marc Pradier, Zeng, Q, Qiandong Zeng, Silva, Evelyn, Gueldener, U., Tudzynski, B, Emmanuel Quévillon, Have, A., ten, Brault, Baptiste, Coutinho, Pedro,, Hahn, M, Oeser, Birgitt, Etienne G Danchin, Plummer, KM, Kodira, Ch., Silva, E., Jan A. L. van Kan, Neuv��glise, C��cile, Amselem, J, Schumacher, J, Amselem, J., Oeser, B, Pascale Cotton, Henrissat, B, Yandava, C, Bettina Tudzynski, Pradier, J., Fournier, Elisabeth, Tudzynski, P, Catherine Sirven, S��gurens, B��atrice, Grossetete, Sandrine, Güldener, U., Collémare, J, Leroch, M, Coutinho, P., Bouzid, Ourdia, Bernard Henrissat, Kohn, L, Simon, A., Adeline Simon, Cotton, Pascale, Rollins, Jeffrey A., Kan, J.A.L., van, Giraud, C, Benito, E.P., Leroch, Michaela, van Kan, J.A.L., Leroch, M., Véronique Anthouard, Ulrich Güldener, Quevillon, Emmanuel, Danchin, Etienne G., Paul S Dyer, Oeser, B., Anthouard, V, Beffa, R., Pearson, M., Giraud, T, Fournier, E, Kodira, C, Tudzynski, P., Isabelle Benoit, Arjen ten Have, Cotton, P., Fillinger-David, Sabine, Helma, Couloux, A., Pearson, Matthew, Sexton, A., Muriel Viaud, Da Silva, C, Poussereau, N., Lebrun, M.H., Anne Lappartient, Julie Poulain, Gueldener, Ulrich, Fillinge, S., Zeng, Qiandong, Gonzalez, C., Pradier, J.M., Chen, Z., Matthew Pearson, Gout, Lilian, Etienne G. Danchin, Nathalie Poussereau, Gautier, Ang��lique, Danchin, Etienne, Wincker, Patrick, Birgitt Oeser, Cotton, P, Sirven, Catherine, de Vries, RP, Evelyn Silva, Adrienne Sexton, Benito, E., Levis, Caroline, Fillinger, S, Have, A., Dyer, P.S., Ségurens, B, Lapalu, N, Baptiste Brault, Corinne Giraud, Oded Yarden, Coutinho, PM, Danchin, E.G., Collemare, J., Simon, Adeline, Neuvéglise, C., Dyer, Paul S., Paul Tudzynski, Christine Rascle, Fillinger, S., Evan Mauceli, Benoit, I., Darren M Soanes, Lilian Gout, Rollins, J.A., Benito, EP, Christina A Cuomo, Anthouard, V��ronique, Sharon, Amir, Gout, L, Béatrice Ségurens, Beever, R.E., Benoit, Isabelle, da Silva, Corinne, Wincker, P, Zeng, Q., Dickman, M., Chen, Z, Rascle, C., Sharon, A., Benito, Ernesto P., G��ldener, Ulrich, Barbara J Howlett, Jeffrey A. Rollins, Amselem, Joelle, Angélique Gautier, Ronald P de Vries, Gonzalez, Celedonio, Neuvéglise, Cécile, Schumacher, Julia, Matt Templeton, Pradier, Jean-Marc, Arnaud Couloux, Chen, Zehua, Mauceli, E., Lapalu, Nicolas, Poulain, J, Quesneville, Hadi, de Vries, R., de Vries, R.P., Jan A L van Kan, Celedonio Gonzalez, Yarden, O, Hahn, M.W., Ronald P. de Vries, Cotton, P.A., Chinnappa Kodira, Ourdia Bouzid, Fillinger, Sabine, Kretschmer, Matthias +341 morecore +2 more sourcesChemoenzymatic Radiosynthesis of a Gluconate Transporter‐Targeted In Vivo Bacterial Sensor From Clinical [18F]FDG
Angewandte Chemie, EarlyView.An efficient radiosynthesis of fluorine‐18 labeled gluconic acid ([18F]FGA) was developed using two readily available materials, 2‐deoxy‐2‐[18F]fluoro‐D‐glucose ([18F]FDG) and glucose oxidase. [18F]FGA is highly specific for bacterial gluconate metabolism mediated by gluconate permease (GntP) and gluconate kinase (GntK), with rapid clearance, low off ...Sang Hee Lee, Jung Min Kim, Joseph Blecha, Robert R. Flavell, Michael A. Ohliger, Joanne Engel, Youngho Seo, David M. Wilson +7 morewiley +2 more sourcesThe Quiet and Underappreciated Rise of Drug-Resistant Invasive Fungal Pathogens
Journal of Fungi, 2020 Human fungal pathogens are attributable to a significant economic burden and mortality worldwide. Antifungal treatments, although limited in number, play a pivotal role in decreasing mortality and morbidities posed by invasive fungal infections (IFIs ...Amir Arastehfar, Cornelia Lass-Flörl, Rocio Garcia-Rubio, Farnaz Daneshnia, Macit Ilkit, Teun Boekhout, Toni Gabaldon, David S. Perlin +7 moredoaj +1 more sourceSymbiont‐Induced HSP83 Establishes Two‐Tiered Control of Antifungal Immunity in an Invasive Beetle–Fungus Complex
Advanced Science, EarlyView.In an invasive beetle–fungus complex, the mutualist Leptographium procerum induces host HSP83 and modulates Toll‐dependent antifungal immunity. HSP83 mediates two‐tiered control by associating with selected fungal recognition receptors and restraining Dorsal‐driven antimicrobial peptide transcription.Qingtai Yang, Zhudong Liu, Yuqiao Yin, Jing Su, Dunyang Yu, Longsheng Xing, Zhen Zou, Le Kang, Jianghua Sun +8 morewiley +1 more sourceValidation and clinical application of molecular methods for the identification of molds in tissue [PDF]
, 2006 Background. Invasive fungal infections due to less-common molds are an increasing problem, and accurate diagnosis is difficult.Methods. We used our previously established molecular method, which allows species identification of molds in histological ...Potter, M, Paterson, PJ, McLaughlin, J, Prentice, HG, McHugh, TD, Kibbler, CC, Seaton, S +6 morecore A Synthetic β‐Mannan Epitope Enables Immunization and Detection of Candida auris
Angewandte Chemie, EarlyView.A synthetic β‐mannan epitope enables both active and passive immunization against Candida auris. Conjugation to the carrier protein CRM197 induces protective antibody responses, while monoclonal antibodies targeting the same epitope support detection using a lateral flow assay, linking glycochemistry with antifungal prevention and diagnostics ...
Emelie E. Reuber, Arnab Pradhan, Ian Leaves, Rajat K. Singh, Emer Hickey, Carola Geiler, Neil A. R. Gow, Alistair J. P. Brown, Peter H. Seeberger +8 morewiley +2 more sourcesLeveraging Microphysiological Systems to Facilitate Neutrophil‐Based Cancer Immunotherapy
Advanced Science, EarlyView.Microphysiological systems are emerging as powerful human‐relevant platforms for studying neutrophil biology in cancer. Current applications of spheroids, organoids, and organ‐on‐a‐chip models are reviewed, together with future opportunities in behaviorome profiling, multi‐omics integration, personalized medicine, immune crosstalk, and multi‐organ ...Shuai Shao, Markus Isfeld Diehl, Caroline N. Jones +2 morewiley +1 more source
