Results 81 to 90 of about 2,119,073 (289)
Drug Resistance and Evolvability in an Emerging Human Fungal Pathogen
mBio, 2022 Over the past decade, Candida auris has emerged as a highly transmissible human fungal pathogen. Because of its ability to transmit between patients in hospitals and its ability to rapidly develop drug resistance, C. auris presents unique challenges.
openaire +3 more sources
Investigations of the Evolved Molecular Basis for Terpenoid Biosynthesis in Marine Sponges
Advanced Science, EarlyView.Confirming and extending a previous observation in another Bubarida sponge, genomic and functional analyses of A. cavernosa reveal that sponges retain the mevalonate pathway and employ single α‐domain T1TSs and UbiA‐type TSs for terpenoid biosynthesis. The absence of T1TSs clustering with other biosynthetic genes tentatively suggests, based on limited ...
Fangyan Chen +6 more
wiley +1 more source
Fungal Pathogens of Maize Gaining Free Passage Along the Silk Road
, 2018 Silks are the long threads at the tips of maize ears onto which pollen land and sperm nuclei travel long distances to fertilize egg cells, giving rise to embryos and seeds; however fungal pathogens also use this route to invade developing grain, causing ...
Manish Raizada +3 more
core +1 more source
Structural and Functional Siderophore Remodeling by Enzymatic Delipidation
Angewandte Chemie, EarlyView.A surprising functional switch in bacterial siderophores was discovered through genome mining and the analysis of environmental and pathogenic Pandoraea species. Pandorachelin B, a lipocyclopeptide that promotes swarming motility, is cleaved by a specialized acylase, yielding a ring‐contracted, homodetic cyclopeptide, pandorachelin A, which exhibits ...
Elena Herzog +5 more
wiley +2 more sources
Genomic and physiological signatures of adaptation in pathogenic fungi
Nature CommunicationsEmerging fungal pathogens have detrimental impacts on crops, animals, and humans. Despite the mounting threat of these emerging fungal pathogens, little is known about their transition from saprotrophic to pathogenic lifestyles.
Marco Alexandre Guerreiro +4 more
doaj +1 more source
Repurposing FDA‐Approved Drugs to Inhibit Fungal PPTases for Broad‐Spectrum Synergy
Advanced Science, EarlyView.Fungal secondary metabolites serve as crucial virulence effectors; however, the potential of their biosynthetic pathways as antifungal targets remains inadequately comprehended. Repurposed FDA‐approved drugs inhibit fungal PPTase (essential for secondary metabolism) in vivo.
Zili Song +7 more
wiley +1 more source
Fungi such as Aspergillus fumigatus, Candida albicans, and Cryptococcus neoformans are opportunistic pathogens in humans. They usually infect individuals whose immune system is compromised due to either a primary infection, e.g., HIV/AIDS, or as part of ...
Colin M. Stack +3 more
core +1 more source
, 2019 International audienceSeminal work by Louis Pasteur revealed the contribution of fungi - yeasts and microsporidia to agro-industry and disease in animals, respectively.
Guilhem Janbon +7 more
core +1 more source
Real-time quantitative PCR for analysis of candidate fungal biopesticides against malaria: Technique validation and first applications [PDF]
, 2009 Recent research has indicated that fungal biopesticides could augment existing malaria vector control tools. Here we present a set of methodologies to monitor the in vivo kinetics of entomopathogenic fungi in Anopheles in the presence or absence of ...
Thomas, Matthew B. +9 more
core +1 more source
, 2022 Fungal pathogens produce a broad array of secondary metabolites (SMs), which allow the fungus to thrive in its natural habitat and gain competitive advantage.
Kuhnert, Eric, Collemare, Jérôme
core +1 more source