Results 211 to 220 of about 2,119,073 (289)

Metabolic Dysfunction‐Associated Steatotic Liver Disease and Obesity: Pathogenesis, Diagnostics, Risk Stratification, and Therapeutic Approach

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Metabolic dysfunction‐associated steatotic liver disease (MASLD) has emerged as the most prevalent chronic liver disease worldwide, closely linked to the global rising incidence of obesity and metabolic syndrome. This review synthesizes current evidence on the pathogenesis, gut–liver axis, and multidisciplinary management of MASLD within the ...
Beom Kyung Kim
wiley   +1 more source

Molecular Epidemiology of <i>Candidozyma auris</i> Within a Case Cluster in North-Central Florida: Diverse Origins and Long-term Persistence of Strains. [PDF]

Open Forum Infect Dis
Morris JG, Tagliamonte MS, Messcher RL, Revazishvili T, Bourgeois BA, Kaplan ZD, Furat EA, Iovine NM, Cherabuddi K, Lednicky JA, Salemi M.   +10 more
europepmc   +1 more source

Proteoforms in Disease: Biomedical Applications of Top‐Down Proteomics

Mass Spectrometry Reviews, EarlyView.
ABSTRACT The proteome is a dynamic landscape of proteoforms arising from genetic mutations, alternative splicing, and post‐translational modifications (PTMs), which collectively drive biological function and disease phenotypes. Mass spectrometry (MS)‐based proteomics has emerged as an essential technique for elucidating this molecular complexity ...
Holden T. Rogers, Zachery R. Gregorich, Megan S. Gant, Zhan Gao, Julia Chamot‐Rooke, Ying Ge   +5 more
wiley   +1 more source

Endophytic Fungal Metabolites as Modulators of Key Signaling Pathways in Chronic Diseases and Aging. [PDF]

Antibiotics (Basel)
Nazir A, Bava P, Hussain A, Amna T, Chand Jamali M, Raza A, Barasarathi J.   +6 more
europepmc   +1 more source

Transforming Musculoskeletal Disorder Management With Multimodal AI Platform for Early Diagnosis, Self‐Screening, and Personalized Care

Med Research, EarlyView.
We developed a multimodal large language model‐enabled framework for the early detection, self‐screening, and personalized management of major musculoskeletal disorders, including osteoarthritis (OA), rheumatoid arthritis (RA), and osteoporosis (OP).
Pengyuan Xu, Guang Yang, Ge Zhang, Yafang Zhao, Pu Wan, Guiyun Zhou, Mengjie Jiang, Yixin Zhang, Zhaoyang Wang, Yichen Dai, Xiqing Zhao, Ziliang Fu, Ziyu Zheng, Ziyun Xu, Ruisi Dong, Xiaojie Xia, Duo Zhang, Yisheng He, Michael Moran, Qiguang Wang, Tim Woodfield, Khoon Lim, Tiantian Kong, Junnan Tang, Kang Tian, Kai Zhou, Hao Chi, Pengpeng Zhang, Jianhua Yang, Mingliang Zhang, Moyan Li, Yuan Cheng, Xiaolin Cui   +32 more
wiley   +1 more source

Cross-kingdom RNA interference as a unifying mechanism in plant-microbe interactions. [PDF]

New Phytol
Gul S, Cheng AP.
europepmc   +1 more source

Senotherapeutics for Knee Osteoarthritis

Medicinal Research Reviews, EarlyView.
ABSTRACT Osteoarthritis (OA) is a chronic disease that imposes a significant economic burden and deteriorates quality of life. Nevertheless, current therapeutic options for OA are limited to symptomatic remedies. As such, there is a high interest in novel methods for treating or preventing OA.
Ezgi Duman, Girish Pattappa, Patrick Pann, Stephan Reppenhagen, Maximilian Rudert, Peter Angele, Denitsa Docheva   +6 more
wiley   +1 more source

Diagnostic Failure in Invasive Fungal Infections: Causes, Clinical Consequences, and Mitigation Strategies. [PDF]

J Fungi (Basel)
Rivas-Pinedo P, Oñate Gutiérrez JM.
europepmc   +1 more source

Boronic Acid Inhibitors of β‐Lactamases: A Promising Strategy Against Antimicrobial Resistance

Medicinal Research Reviews, EarlyView.
ABSTRACT The rise of antimicrobial resistance (AMR) poses a critical threat to global health, mostly due to the proliferation of β‐lactamases, a class of enzymes responsible for the inactivation of β‐lactam antibiotics. Among the most promising strategies to restore β‐lactam efficacy is the use of β‐lactamase inhibitors (BLIs), with boronic acid ...
Nicolò Santi, Federico Corsini, Robert A. Bonomo, Emilia Caselli, Fabio Prati   +4 more
wiley   +1 more source

14‐3‐3 proteins orchestrate rice immunity through protein turnover and redox signaling

New Plant Protection, EarlyView.
Abstract 14‐3‐3 proteins are a highly conserved family of regulatory proteins that orchestrate diverse cellular processes through interactions with phosphorylated target proteins. Recent studies have identified rice 14‐3‐3 proteins as pivotal regulators of plant immunity, revealing both positive and negative roles in defense against the blast fungus ...
Colton Jordan, Guo‐Liang Wang
wiley   +1 more source