Results 171 to 180 of about 6,268 (192)

N-terminal tags impair the ability of lamin A to provide structural support to the nucleus.

J Cell Sci
Odell J, Lammerding J.
europepmc   +1 more source

Prevalence of lamin and emerin deficit in scapuloperoneal myopathy

, 2004
Azorin, I, Mayordomo, E, Bataller, L, SEVILLA, T., Vilchez, JJ   +4 more
openaire   +1 more source

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The molecular basis of emerin-emerin and emerin-BAF interactions.

Journal of cell science, 2015
Emerin is a conserved membrane component of nuclear lamina structure. Here, we report an advance in understanding the molecular basis of emerin function: intermolecular emerin-emerin association. There were two modes: one mediated by association of residues 170-220 in one emerin molecule to residues 170-220 in another, and the second involving residues
Jason M, Berk, Dan N, Simon, Clifton R, Jenkins-Houk, Jason W, Westerbeck, Line M, Grønning-Wang, Cathrine R, Carlson, Katherine L, Wilson   +6 more
openaire   +2 more sources

Emerin presence in platelets

Acta Neuropathologica, 2000
Emerin is an almost ubiquitous protein which is abnormal in X-linked Emery-Dreifuss muscular dystrophy (EMD), a syndrome characterized by muscle weakness, joint contractures and cardiac arrhythmia. Emerin is localized in the cells at the nuclear rim and its function is still unknown.
S, Squarzoni, P, Sabatelli, C, Capanni, S, Petrini, A, Ognibene, D, Toniolo, F, Cobianchi, G, Zauli, A, Bassini, A, Baracca, C, Guarnieri, L, Merlini, N M, Maraldi   +12 more
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Interaction between Emerin and Nuclear Lamins

Journal of Biochemistry, 2001
Emerin is an inner nuclear membrane protein that is involved in X-linked recessive Emery-Dreifuss muscular dystrophy (X-EDMD). Although the function of this protein is still unknown, we revealed that C-terminus transmembrane domain-truncated emerin (amino acid 1-225) binds to lamin A with higher affinity than lamin C.
M, Sakaki, H, Koike, N, Takahashi, N, Sasagawa, S, Tomioka, K, Arahata, S, Ishiura   +6 more
openaire   +2 more sources

Direct Interaction between Emerin and Lamin A

Biochemical and Biophysical Research Communications, 2000
Emerin is the protein of the inner nuclear membrane that is affected by mutation in X-linked Emery-Dreifuss muscular dystrophy. The autosomal dominant form of the disease is caused by mutations in the lamin A/C gene. Several lines of circumstantial evidence have suggested an interaction of emerin with lamins in the nuclear lamina but direct interaction
L, Clements, S, Manilal, D R, Love, G E, Morris   +3 more
openaire   +2 more sources

Two distal mutations in the gene encoding emerin have profoundly different effects on emerin protein expression

Neuromuscular Disorders, 2000
Emerin, the product of the gene responsible for X-linked Emery-Dreifuss muscular dystrophy (EDMD), has a ubiquitous tissue distribution and is localised to the nuclear envelope. We present here the relationship between emerin protein expression, nuclear localization and clinical phenotype for two distal mutations identified in unrelated EDMD patients ...
Ellis, J A, Brown, C A, Tilley, L D, Kendrick-Jones, J, Spence, J E, Yates, J R   +5 more
openaire   +3 more sources

Emerin

The International Journal of Biochemistry & Cell Biology, 1999
Emerin encoded by the STA gene is the first nuclear protein linked with a muscular dystrophy. Emerin is a 34 kDa, predominantly hydrophilic protein with a single hydrophobic region supposed to serve as a transmembrane domain. It was classified as a type II integral membrane protein localized at the inner nuclear membrane/nuclear lamina with an ...
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Acute downregulation of emerin alters actomyosin cytoskeleton connectivity and function

Biophysical Journal, 2023
Fetal lung fibroblasts contribute dynamic infrastructure for the developing lung. These cells undergo dynamic mechanical transitions, including cyclic stretch and spreading, which are integral to lung growth in utero. We investigated the role of the nuclear envelope protein emerin in cellular responses to these dynamic mechanical transitions.
Qianru Jin, Deepesh Pandey, Carol B. Thompson, Shawna Lewis, Hyun Woo Sung, Thao D. Nguyen, Scot Kuo, Katherine L. Wilson, David H. Gracias, Lewis H. Romer   +9 more
openaire   +2 more sources