Results 91 to 100 of about 13,374 (270)

LP‐003, a novel high‐affinity anti‐IgE antibody for inadequately controlled seasonal allergic rhinitis: A multicenter, randomized, double‐blind, placebo‐controlled phase 2 clinical trial

Clinical and Translational Allergy, Volume 15, Issue 6, June 2025.
Abstract Background Anti‐IgE therapy can serve as an option for inadequately controlled seasonal allergic rhinitis (SAR) patients. LP‐003, a novel anti‐IgE antibody, is being tested as an add‐on treatment for SAR. This trial aimed to evaluate whether LP‐003 is effective and safe for SAR.
Kai Guan, Shuang Liu, Yan Feng, Lisha Li, Xiaoming Zhu, Nai‐Chau‐Sun Bill, Haili Ma, Jie Yang, Cuicui Han, Heng Liu, Qingyu Wei, Haiyun Shi, Xueyan Wang   +12 more
wiley   +1 more source

Turning the Tide: Natural Products and Natural-Product-Inspired Chemicals as Potential Counters to SARS-CoV-2 Infection

Frontiers in Pharmacology, 2020
The novel and highly pathogenic severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which causes coronavirus disease 2019 (COVID-19), has become a continued focus of global attention due to the serious threat it poses to public health.
Zhonglei Wang, Zhonglei Wang, Liyan Yang
doaj   +1 more source

Plasticity of Gene Expression in Spaceflight and Postflight in Relation to Cardiovascular Disease: Mechanisms and Candidate Repurposed Drugs

PROTEOMICS, Volume 25, Issue 11-12, June 2025.
ABSTRACT Spaceflight poses unique challenges to human health due to exposure to increased levels of cosmic radiation, microgravity, and associated oxidative stress. These environmental factors can lead to cellular damage, inflammation, and a range of health complications, including cardiovascular problems, immune system impairment, and an increased ...
Marilena M. Bourdakou, Eleni M. Loizidou, George M. Spyrou   +2 more
wiley   +1 more source

SARS-CoV-2 Nsp1 mediated mRNA degradation requires mRNA interaction with the ribosome

RNA Biology, 2023
Nsp1 is a SARS-CoV-2 host shutoff factor that both represses cellular translation and promotes host RNA decay. However, it is unclear how these two activities are connected and interact with normal translation processes.
Soraya I. Shehata, Roy Parker
doaj   +1 more source

Organoid‐based precision medicine in pancreatic cancer

United European Gastroenterology Journal, Volume 13, Issue 1, Page 21-33, February 2025.
Abstract Pancreatic ductal adenocarcinoma (PDAC) ranks among the leading causes of cancer‐related deaths worldwide. Despite advances in precision oncology in other malignancies, treatment of PDAC still largely relies on conventional chemotherapy. Given the dismal prognosis and heterogeneity in PDAC, there is an urgent need for personalized therapeutic ...
Alica K. Beutel, Menar Ekizce, Thomas J. Ettrich, Thomas Seufferlein, Jessica Lindenmayer, Johann Gout, Alexander Kleger   +6 more
wiley   +1 more source

5-HT2a receptor in mPFC influences context-guided reconsolidation of object memory in perirhinal cortex [PDF]

, 2018
Context-dependent memories may guide adaptive behavior relaying in previous experience while updating stored information through reconsolidation. Retrieval can be triggered by partial and shared cues.
Bekinschtein, Pedro Alejandro, Gallo, Francisco Tomás, Miranda, Magdalena, Morici, Juan Facundo, Weisstaub, Noelia V., Zanoni Saad, María Belén   +5 more
core   +1 more source

Investigation of Novel Isatinylhydantoin Derivatives as Potential Anti‐Kinetoplastid Agents

ChemMedChem, Volume 20, Issue 1, January 2, 2025.
A series of isatinylhydantoin derivatives were synthesized and investigated for antileishmanial and antitrypanosomal activities in vitro and in vivo. The derivative 5 was identified with higher leishmanicidal activity than the clinical drug amphotericin B while 4b was uncovered as in vitro trypanocidal hit against T. congolense parasite.
Keamogetswe Sechoaro, Janine Aucamp, Christina Kannigadu, Helena D. Janse van Rensburg, Keisuke Suganuma, David D. N'Da   +5 more
wiley   +1 more source

Exploration of Novel “Ferroxazide/Ferrazone” Derivatives as Antitrypanosomatid Agents: Design, Synthesis, and Biological Efficacy

Applied Organometallic Chemistry, Volume 39, Issue 1, January 2025.
A series of novel ferrocene derivatives, mimics of the clinical antibiotics, nifuroxazide and nitrofurazone, termed ferroxazides and ferrazones, respectively, were synthesized and evaluated for antitrypanosomatid activities. The ferroxazide 15 bearing dimethylamino moiety was identified in vitro as hit against Trypanosoma congolense strain but ...
Christina Kannigadu, Helena D. Janse van Rensburg, Janine Aucamp, Keisuke Suganuma, David D. N'Da   +4 more
wiley   +1 more source

Ars Magna: The Ten-Square [PDF]

, 1985
Word squares have always fascinated me. From an early age I took delight in devising regular 3-by-3 and 4-by-4 squares, perhaps to the detriment of a few well-meaning teachers, who mistook my linguistic activities for doodling.
Grant, Jeff
core   +1 more source

Hsp70–Bag3 complex is a hub for proteotoxicity-induced signaling that controls protein aggregation [PDF]

, 2019
Protein abnormalities in cells are the cause of major pathologies, and a number of adaptive responses have evolved to relieve the toxicity of misfolded polypeptides.
Alexandrov, Ilya, Cisse, Ibrahim I, Meng, Le, Meriin, Anatoli B., Narayanan, Arjun V., Sherman, Michael Y., Varelas, Xaralabos   +6 more
core   +1 more source