Results 71 to 80 of about 3,807,656 (336)

IRAS 16293-2422: Evidence for Infall onto a Counter-Rotating Protostellar Accretion Disk [PDF]

open access: yes, 2005
We report high spatial resolution VLA observations of the low-mass star-forming region IRAS 16293-2422 using four molecular probes: ethyl cyanide (CH$_3$CH$_2$CN), methyl formate (CH$_3$OCHO), formic acid (HCOOH), and the ground vibrational state of ...
Hollis, J. M., Remijan, Anthony J.
core   +3 more sources

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

open access: yesMolecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto   +13 more
wiley   +1 more source

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

open access: yesMolecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad   +12 more
wiley   +1 more source

Estimating Total Methane Emissions from the Denver-Julesburg Basin Using Bottom-Up Approaches

open access: yesGases
Methane is a powerful greenhouse gas with a 25 times higher 100-year warming potential than carbon dioxide and is a target for mitigation to achieve climate goals. To control and curb methane emissions, estimates are required from the sources and sectors
Stuart N. Riddick   +6 more
doaj   +1 more source

Ground-based NIR emission spectroscopy of HD189733b

open access: yes, 2011
We investigate the K and L band dayside emission of the hot-Jupiter HD 189733b with three nights of secondary eclipse data obtained with the SpeX instrument on the NASA IRTF.
Agol   +21 more
core   +2 more sources

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

open access: yesMolecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller   +17 more
wiley   +1 more source

Impact analysis of Advanced Driver Assistance Systems (ADAS) regarding road safety – computing reduction potentials

open access: yesEuropean Transport Research Review
In the present study road safety impact analysis for certain advanced driver assistance systems (ADAS) was conducted. Based on a literature review, expert interviews and current adaptations in legislation, the most promising nine ADAS were selected.
Michael Aleksa   +5 more
doaj   +1 more source

Computational Fluid Dynamics-Based Modeling of Methane Flows Around Oil and Gas Equipment

open access: yesAtmosphere
Recent studies estimate that emissions from oil and gas production facilities contribute between 20 and 50% of the total methane (CH4) emitted in the US; therefore, quantifying and reducing these emissions are crucial for achieving climate goals. Methane
Abhinav Anand   +7 more
doaj   +1 more source

A correlation between the IRAS infrared cirrus at 60 or 100 microns and neutral atomic hydrogen in the outer galaxy [PDF]

open access: yes
A linear correlation was found between the infrared cirrus at 100 or 60 microns and neutral atomic hydrogen near the galactic plane. Infrared Astronomy Satellite (IRAS) Sky Brightness images were compared to the 0.5 deg resolution Weaver-Williams HI ...
hermal dust emission., Terebey, Susan
core   +1 more source

Pulsar optical emission as amplified synchrotron emission [PDF]

open access: yesMonthly Notices of the Royal Astronomical Society, 1981
Pulsed optical emission has been observed from the Crab and Vela pulsars (Manchester and Taylor 1977). The pulse profile of the Crab pulsar has a main pulse and a strong interpulse separated by about 40% of the pulsar period; the peak of the main pulse is just resolved at 20 μs resolution; the spectrum is peaked at about 1014.8 Hz; the pulse profile is
openaire   +2 more sources

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