Results 41 to 50 of about 9,614 (265)

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

New Symbiotic Stars from LAMOST DR10 Spectra and Multiband Photometry

The Astrophysical Journal
The Symbiotic star (SySt) is a long-period interacting binary system, typically consisting of a white dwarf (WD) and a red giant surrounded by a nebula. These systems are natural astrophysical laboratories for investigating binary star evolution. In this
Jing Chen, Liang Wang, Yin-Bi Li, Xiao-Xiao Ma, A-Li Luo, Zi-Chong Zhang, Ming-Yi Ding, Kai Zhang   +7 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

CO Second Overtone Line Variability in Three Carbon-rich Early Post–Asymptotic Giant Branch Stage Stars

The Astrophysical Journal
Near-infrared CO molecular lines are suggested to be linked with dynamic processes in post–asymptotic giant branch (post-AGB) stars; however, they have not been investigated at high spectral resolution.
Kārlis Puķītis
doaj   +1 more source

Mapping the line emission distribution of cataclismic variable stars [PDF]

Astrophysics and Space Science, 1987
AbstractWe describe a method for imaging the accretion disc of a Cataclysmic Variable star. We use the two-dimensional information contained in the line profiles as they vary with phase to invert the line formation process. Asymmetries in the disc, as are caused by the bright-spot, for example, are accounted for naturally.
T. R. Marsh, K. Horne
openaire   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

H2 Line Emission Associated with the Formation of the First Stars [PDF]

Publications of the Astronomical Society of Japan, 2004
Abstract Molecular hydrogen ($\mathrm{H}_2$) line radiation emitted in the formation events of first-generation stars is evaluated in a discussion of its detectability by future observational facilities. $\mathrm{H}_2$ luminosity evolution from the onset of prestellar collapse until the formation of a $\sim 100 \,{{{M}_{\odot ...
Mizusawa, Hiromi, Nishi, Ryoichi, Omukai, Kazuyuki   +2 more
openaire   +2 more sources

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Identification of New Be Stars from LAMOST Data Release 11 Based on Deep Learning

The Astrophysical Journal Supplement Series
Be stars are rapidly rotating B-type stars that exhibit Balmer emission lines in their optical spectra, which makes them crucial for studying stellar evolution and circumstellar disk structures.
Lei Tan, Hui Deng, Tianhang Liu, Huanbin Chi, Yixing Chen, Ying Mei, Feng Wang   +6 more
doaj   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source