Results 1 to 10 of about 12,564 (213)

Evaluation of the inhibitory effects of emodin on Neospora caninum invasion and proliferation in vitro [PDF]

International Journal for Parasitology: Drugs and Drug Resistance
The impact of neosporosis on the livestock industry has worsening each year. Globally, annual losses were estimated to exceed $2.4 billion, with abortion rates reaching up to 47 % in affected herds.
Feixue Liu, Jianhua Li, Xin Li, Xu Zhang, Liuzhenxiu Yan, Lanbi Gao, Zhenzhen Liu, Pengtao Gong, Nan Zhang, Xichen Zhang, Xiaocen Wang   +10 more
doaj   +2 more sources

Emodin alleviates cardiac fibrosis by suppressing activation of cardiac fibroblasts via upregulating metastasis associated protein 3

Acta Pharmaceutica Sinica B, 2019
Excess activation of cardiac fibroblasts inevitably induces cardiac fibrosis. Emodin has been used as a natural medicine against several chronic diseases.
Hongtao Diao, Yuan Lin, Yong Zhang
exaly   +3 more sources

Emodin inhibits colon cancer tumor growth by suppressing tumor cell glycolysis through inhibition of NAT10-mediated PGK1 ac4C modification [PDF]

Frontiers in Oncology
IntroductionInhibition of glycolysis represents a potent therapeutic approach for colon cancer. Emodin, a natural plant-derived compound with anticancer properties, has shown efficacy in cancer treatment.
Zhuoxin Wei, Zhuo Lv, Weimin Zhang
doaj   +2 more sources

Emodin targets the β-hydroxyacyl-acyl carrier protein dehydratase from Helicobacter pylori: enzymatic inhibition assay with crystal structural and thermodynamic characterization [PDF]

BMC Microbiology, 2009
Background The natural product Emodin demonstrates a wide range of pharmacological properties including anticancer, anti-inflammatory, antiproliferation, vasorelaxant and anti-H. pylori activities. Although its H.
Jiang Hualiang, Guo Yuewei, Du Jiamu, Ding Jianping, Zhang Haitao, Zhang Yu, Zhang Liang, Chen Jing, Shen Xu   +8 more
doaj   +2 more sources

Nanoparticle-Mediated Delivery of Emodin via Colonic Irrigation Attenuates Renal Injury in 5/6 Nephrectomized Rats

Frontiers in Pharmacology, 2021
Our previous study showed that emodin enema modulates gut microbiota and delays CKD progression. However, the poor solubility, limited colonic irrigation retention time, and inadequate colon adhesion of emodin hinder its clinical application.
Zhaoyu Lu, Zhaoyu Lu, Chunlan Ji, Chunlan Ji, Xuewen Luo, Yong Lan, Lijuan Han, Yang Chen, Xusheng Liu, Qinzhan Lin, Fuhua Lu, Xiuqing Wu, Rui Guo, Chuan Zou   +13 more
doaj   +1 more source

Emodin inhibits invasion and migration of hepatocellular carcinoma cells via regulating autophagy-mediated degradation of snail and β-catenin

BMC Cancer, 2022
Background Previous studies reported that emodin extracted from Rheum palmatum L. exerts antiproliferation and antimetastatic effects in a variety of human cancer types.
Binyu Qin, Zhili Zeng, Jianliang Xu, Jing Shangwen, Zeng Jie Ye, Shutang Wang, Yanheng Wu, Gongfeng Peng, Qi Wang, Wenyi Gu, Ying Tang   +10 more
doaj   +1 more source

Emodin reverses leukemia multidrug resistance by competitive inhibition and downregulation of P-glycoprotein. [PDF]

PLoS ONE, 2017
Development of multidrug resistance (MDR) is a continuous clinical challenge partially due to the overexpression of P-glycoprotein (P-gp) for chronic myelogenous leukemia (CML) patients.
Hongping Min, Miaomiao Niu, Weilin Zhang, Jia Yan, Jiachang Li, Xiying Tan, Bo Li, Mengxiang Su, Bin Di, Fang Yan   +9 more
doaj   +1 more source

Adsorption Characteristics and Enrichment of Emodin from Marine-Derived Aspergillus flavipes HN4-13 Extract by Macroporous Resin XAD-16

Marine Drugs, 2022
Emodin, a hydroxyanthraquinone derivative, has been used as medicine for more than 2000 years due to its extensive pharmacological activities. Large-scale production of emodin has been achieved by optimizing the fermentation conditions of marine-derived ...
Lizhi Gong, Yuzhen Wu, Xiaohan Qiu, Xiujuan Xin, Faliang An, Miaomiao Guo   +5 more
doaj   +1 more source

Emodin prevents renal ischemia-reperfusion injury via suppression of p53-mediated cell apoptosis based on network pharmacology

Heliyon, 2023
Background: Previous evidence indicated that emodin has significant advantages for preventing acute kidney injury (AKI). However, the mechanisms responsible for these effects of emodin have yet to be elucidated.
Hongmei Lu, Dengpiao Xie, Bo Qu, Mingquan Li, Yuhua He, Weijing Liu   +5 more
doaj   +1 more source

Emodin regulates cell cycle of non-small lung cancer (NSCLC) cells through hyaluronan synthase 2 (HA2)-HA-CD44/receptor for hyaluronic acid-mediated motility (RHAMM) interaction-dependent signaling pathway

Cancer Cell International, 2021
Background Non-small cell lung cancers (NSCLC) account for most cases of lung cancer. More effort is needed to research new drug and combination therapies for this disease. An anthraquinone derivative, emodin shows anticancer potency.
Mingzhu Li, Shengbo Jin, Yang Cao, Jian Xu, Shendong Zhu, Zheng Li   +5 more
doaj   +1 more source