Results 41 to 50 of about 94,361 (225)

Pharmacokinetic Drug–Drug Interaction Potential of Oral Anticancer Drugs

Clinical Pharmacology &Therapeutics, EarlyView.
Drug–drug interaction (DDI) management is critical for safe and effective use of oral anticancer drugs (OADs). Our study objectives were to (i) compile clinically relevant pharmacokinetic (PK) DDI mechanisms for OADs and (ii) assess the prevalence of PK potential DDIs (PDDIs) in patients with advanced solid cancers.
Fatimah Alhurayri, Islam R. Younis, Shadia I. Jalal, Theodore F. Logan, Rohan Maniar, Steven M. Bray, Sara K. Quinney, Zeruesenay Desta, Todd C. Skaar, James E. Tisdale, Tyler Shugg   +10 more
wiley   +1 more source

Cytologic Findings in Esophageal Perforation: An Institutional Experience With Pleural Fluid Specimens

Diagnostic Cytopathology, EarlyView.
ABSTRACT Introduction Esophageal perforation (EP) is a rare but life‐threatening condition, and most cases are due to iatrogenic causes. The rest occur spontaneously, due to malignancies, or trauma. The mortality rates can approach 50%, and delayed diagnosis of EP exacerbates patient outcomes.
Mason Marshall, Samer Khader, Sigfred Lajara, Liron Pantanowitz   +3 more
wiley   +1 more source

Hypervision Proton Surgery: The Future Direction of Proton Therapy

iNew Medicine, EarlyView.
ABSTRACT Proton beams provide unique physical advantages characterized by a low entrance dose, negligible exit dose, and a sharp Bragg peak, which enable superior sparing of normal tissues and support safe dose escalation for improved tumor control. However, conventional photon‐based fractionation remains widely used in proton therapy, where prolonged ...
Li Li, Shuanghu Yuan
wiley   +1 more source

Analysis of Pulsatile Vessel Expansion in Healthy, COPD‐and PH‐Patients Using Dynamic Vessel Segmentation in Free‐Breathing Lung MRI

Journal of Magnetic Resonance Imaging, EarlyView.
ABSTRACT Background The pulsatile expansion of pulmonary vessels carries dynamic cardiopulmonary information that may reveal disease earlier than structural changes alone. Purpose To test (i) intra‐ and inter‐scan repeatability of dynamic vessel metrics in healthy subjects, and (ii) whether chronic obstructive pulmonary disease (COPD) and postcapillary
Julian Glandorf, Marius M. Klein, Filip Klimeš, Agilo Luitger Kern, Marcel Gutberlet, Jens M. Hohlfeld, Marius M. Hoeper, Karen M. Olsson, Frank Wacker, Jens Vogel‐Claussen, Andreas Voskrebenzev   +10 more
wiley   +1 more source

Airway and emphysema assessment by quantitative CT among emphysema phenotype of chronic obstructive pulmonary disease

The Egyptian Journal of Radiology and Nuclear Medicine
Background Chronic obstructive pulmonary disease (COPD) has been a major public health problem. Although pulmonary function test remains the primary diagnostic method, quantitative computed tomography (QCT) analysis has become more significant in the ...
Taghreed Abdelaziz Nasr, Hosny Abdelghany, Nasr M. Osman, Azza Farag Said, Mohamed Ahmed Abdelsamie   +4 more
doaj   +1 more source

Biofilm removal capacity and titanium surface integrity in non‐abrasive versus abrasive peri‐implantitis cleaning interventions

Journal of Periodontology, EarlyView.
Abstract Background Current peri‐implantitis treatment methods are modeled after dental cleaning modalities like abrasive surface cleaning. However, mechanical abrasive cleaning not only inadequately removes implant biofilms but also compromises implant surface integrity with adverse biological effects.
Marzieh S. Jazaeri, Danyal A. Siddiqui, Yi‐Wen C. Tsai, Kathryn Gabel, Zachary Lorenzana, Georgios A. Kotsakis   +5 more
wiley   +1 more source

Effect of emphysema on AI software and human reader performance in lung nodule detection from low-dose chest CT

European Radiology Experimental
Background Emphysema influences the appearance of lung tissue in computed tomography (CT). We evaluated whether this affects lung nodule detection by artificial intelligence (AI) and human readers (HR).
Nikos Sourlos, GertJan Pelgrim, Hendrik Joost Wisselink, Xiaofei Yang, Gonda de Jonge, Mieneke Rook, Mathias Prokop, Grigory Sidorenkov, Marcel van Tuinen, Rozemarijn Vliegenthart, Peter M. A. van Ooijen   +10 more
doaj   +1 more source

Exercise intolerance and systemic manifestations of pulmonary emphysema in a mouse model

Respiratory Research, 2009
Background Systemic effects of chronic obstructive pulmonary disease (COPD) significantly contribute to severity and mortality of the disease. We aimed to develop a COPD/emphysema model exhibiting systemic manifestations of the disease.
Hasenfuss Gerd, Unsöld Bernhard, Michels Hellmuth, Raupach Tobias, Lüthje Lars, Kögler Harald, Andreas Stefan   +6 more
doaj   +1 more source

Dose‐dependent association of systemic comorbidities with periodontitis severity: A large population cross‐sectional study

Journal of Periodontology, EarlyView.
Abstract Background To examine whether the associations between periodontitis and multiple systemic conditions increase with increasing severity of periodontitis using a multi‐center electronic health record (EHR) repository. Methods A cross‐sectional analysis was conducted using EHR data from 9 dental schools in the United States.
Muhammad H. A. Saleh, Hamoun Sabri
wiley   +1 more source

CT-defined Emphysema Morphology as a Predictor for Histological Subtypes of Lung Cancer: A Single-center Retrospective Study

Thoracic Research and Practice
OBJECTIVE: Lung cancer and pulmonary emphysema share common risk factors and pathophysiological pathways. Emerging evidence suggests that emphysema morphology, rather than emphysema burden, may influence lung cancer histology.
Fadlan Adima Adrianta, Dini Rachma Erawati, Suryanti Dwi Pratiwi, Nanik Setijowati   +3 more
doaj   +1 more source