Results 71 to 80 of about 166,649 (285)

Effect of emphysema on AI software and human reader performance in lung nodule detection from low-dose chest CT

European Radiology Experimental
Background Emphysema influences the appearance of lung tissue in computed tomography (CT). We evaluated whether this affects lung nodule detection by artificial intelligence (AI) and human readers (HR).
Nikos Sourlos, GertJan Pelgrim, Hendrik Joost Wisselink, Xiaofei Yang, Gonda de Jonge, Mieneke Rook, Mathias Prokop, Grigory Sidorenkov, Marcel van Tuinen, Rozemarijn Vliegenthart, Peter M. A. van Ooijen   +10 more
doaj   +1 more source

Exercise intolerance and systemic manifestations of pulmonary emphysema in a mouse model

Respiratory Research, 2009
Background Systemic effects of chronic obstructive pulmonary disease (COPD) significantly contribute to severity and mortality of the disease. We aimed to develop a COPD/emphysema model exhibiting systemic manifestations of the disease.
Hasenfuss Gerd, Unsöld Bernhard, Michels Hellmuth, Raupach Tobias, Lüthje Lars, Kögler Harald, Andreas Stefan   +6 more
doaj   +1 more source

Prophylactic tracheostomy in aged and poor risk general surgical patients [PDF]

, 1959
The most common postoperative complications are those involving respiration, and they are especially dangerous to patients classified as poor risks because of age or other handicaps.
Farrell, JJ, Meyer, WH, Starzl, TE
core   +1 more source

Endoplasmic reticulum stress and the unfolded protein response in lung diseases: molecular pathways and therapeutic interventions

The Journal of Pathology, EarlyView.
Abstract Endoplasmic reticulum stress (ERS) occurs when the protein‐folding capacity of the endoplasmic reticulum (ER) is overwhelmed, triggering the unfolded protein response (UPR) to restore homeostasis. However, severe or persistent ERS can shift the UPR toward pro‐inflammatory, apoptotic, and fibrotic signaling, thereby exacerbating tissue injury ...
Lanlan Song, Yichen Liu, Chen Xu, Yaochen Zhang, Kaiming Xu, Dan Yao, Xiaoying Huang   +6 more
wiley   +1 more source

Barnes Hospital Bulletin [PDF]

, 1968
https://digitalcommons.wustl.edu/bjc_barnes_bulletin/1041/thumbnail ...

core   +1 more source

Epigenetic Dysregulation of the NKX2‐1/SPDEF Axis Drives Persistent Goblet Cell Differentiation and Epithelial Barrier Dysfunction in Chronic Obstructive Pulmonary Disease

Respirology, EarlyView.
This study investigated airway epithelial barrier dysfunction persistence in ex‐smokers with COPD and underlying mechanisms using single‐cell RNA and ATAC sequencing. Epigenetic NKX2‐1/SPDEF dysregulation maintains goblet cell hyperplasia and barrier dysfunction despite long‐term smoking cessation.
Ayaka Shiota, Keiko Kan‐o, Yumiko Ishii, Tomoaki Koga, Takeshi Sawada, Kei‐ichiro Yasunaga, Shingo Usuki, Tatsuya Katsuno, Shigesato Inoue, Tomohiro Ogawa, Akihiro Jo, Satoru Fukuyama, Mitsuyoshi Nakao, Hiroaki Ogata, Mizuho A. Kido, Sachiko Tsukita, Koichiro Matsumoto, Isamu Okamoto   +17 more
wiley   +1 more source

Higher body mass index is associated with increased lung stiffness and less airway obstruction in individuals with asthma and fixed airflow obstruction

ERJ Open Research, 2021
Sandra Rutting, David G. Chapman, Tanya Badal, Farid Sanai, Sabine C. Zimmermann, Cindy Thamrin, Gregory G. King, Katrina O. Tonga   +7 more
doaj   +1 more source

Hepatocyte and keratinocyte growth factors and their receptors in human lung emphysema

BMC Pulmonary Medicine, 2005
Background Hepatocyte and keratinocyte growth factors are key growth factors in the process of alveolar repair. We hypothesized that excessive alveolar destruction observed in lung emphysema involves impaired expression of hepatocyte and keratinocyte ...
Marchal Joëlle, Leçon-Malas Véronique, Boutten Anne, Bonay Marcel, Soler Paul, Fournier Michel, Leseche Guy, Dehoux Monique, Crestani Bruno   +8 more
doaj   +1 more source

Novel Therapeutics for Chronic Obstructive Pulmonary Disease: From Empirical Bronchodilation to Precision Medicine

Respirology, EarlyView.
ABSTRACT Chronic obstructive pulmonary disease (COPD) remains the third leading cause of death worldwide, and conventional bronchodilator‐based therapies have limited efficacy in preventing exacerbations and disease progression. The 2024–2026 period represents a historic inflection point: three mechanistically distinct agents received Food and Drug ...
Naoya Fujino, Hisatoshi Sugiura
wiley   +1 more source

Characteristics of phenotypes of elderly patients with asthma

Allergology International, 2016
Background: The characteristics of phenotypes of elderly patients with asthma are unknown. The aim of this study was to classify these phenotypes using lung function tests and images from high-resolution computed tomography (HRCT), and to identify ...
Hiroyuki Sano, Takashi Iwanaga, Osamu Nishiyama, Akiko Sano, Yuji Higashimoto, Katsuyuki Tomita, Yuji Tohda   +6 more
doaj   +1 more source