Results 71 to 80 of about 97,184 (241)

The role of pain in Graves' orbitopathy: Associations with clinical activity and quality of life

open access: yesActa Ophthalmologica, EarlyView.
Abstract Purpose Pain is included in the clinical activity score (CAS) as an indicator of inflammatory activity in Graves' orbitopathy (GO), yet its clinical relevance has not been systematically evaluated. We therefore investigated the relationship between pain, other inflammatory signs and quality of life (QoL), and assessed the effect of intravenous
Gijsbert J. Hötte   +7 more
wiley   +1 more source

The relation between clinical response and quality of life improvement after treatment with intravenous methylprednisolone in Graves' orbitopathy

open access: yesActa Ophthalmologica, EarlyView.
Abstract Background Quality of life (QoL) is a key outcome in Graves' orbitopathy (GO), but prior studies have reported overall QoL changes without evaluating whether improvements occur specifically in patients who achieve objective clinical response.
Gijsbert J. Hötte   +8 more
wiley   +1 more source

Correction: Development of a 4-aminopyrazolo[3,4-d]pyrimidine-based dual IGF1R/Src inhibitor as a novel anticancer agent with minimal toxicity

open access: yesMolecular Cancer, 2023
Ho Jin Lee   +8 more
doaj   +1 more source

Narrative Review on Therapies That Influence Inflammatory Responses During Extremely Premature Perinatal Respiratory Transition

open access: yesActa Paediatrica, EarlyView.
ABSTRACT Aims and Methods Advances in neonatal care have extended borderline survival to 22–24 post‐conceptional weeks. Present review discusses approaches for prolonging short pregnancies and prevention of serious morbidities in extremely premature infants born before 28 weeks of pregnancy.
Mikko Hallman
wiley   +1 more source

Meta‐Analysis: Redefining Liver Disease Risk in Heterozygous Alpha‐1 Antitrypsin Deficiency

open access: yesAlimentary Pharmacology &Therapeutics, EarlyView.
SERPINA1 MZ/SZ genotypes is a common but under‐recognised liver risk state. Despite modest shifts in liver function tests, it is associated with approximately doubled odds of fibrosis, cirrhosis, and liver transplantation, supporting its inclusion in chronic liver disease risk assessment.
Adam M. Syanda   +8 more
wiley   +1 more source

Treatment For Subcutaneous Emphysema From Dental/OMFS Procedures: A Systematic Review

open access: yesDentistry Review
OBJECTIVES: Review causes of subcutaneous emphysema in the dental setting Evaluate trends in treatment of subcutaneous emphysema from 2009-2015, especially regarding antibiotics for this condition METHODS: We used the PubMed and web of science databases ...
Macarius Abdelsayed, Matthew Zhang
doaj   +1 more source

The lung is more than an organ of gas exchange: immunocompetency, platelets and implications for drug discovery

open access: yesBritish Journal of Pharmacology, EarlyView.
Abstract The lungs have for a long time been recognised as having pharmacological significance as a specific organ to modulate the pharmacokinetics of endogenous substances needed to maintain homeostasis. The lungs are therefore the site of action of certain drugs that act on these homeostatic processes, resulting in systemic effects on the ...
Simon C. Pitchford
wiley   +1 more source

Localized emphysema [PDF]

open access: yesActa Radiologica, 1960
S, BRUNNER, O C, POCK-STEEN
openaire   +2 more sources

Targeting m6A Modifications Regulating Ferroptosis Offers Novel Therapy in Diseases

open access: yesCell Proliferation, EarlyView.
m6A RNA modification regulates ferroptosis by balancing iron metabolism, lipid peroxidation, and antioxidant defenses. Dysregulated m6A signaling disrupts pro‐ and anti‐ferroptotic factors, leading to excess ROS, Fe3+ accumulation, and lipid peroxidation–driven cell death. Targeting m6A‐mediated ferroptotic regulation represents a promising therapeutic
Lida Du   +7 more
wiley   +1 more source

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