Results 81 to 90 of about 219,949 (396)

The association of chest computed tomography-defined visual emphysema and prognosis in patients with nonsmall cell lung cancer

ERJ Open Research, 2023
Background Although computed tomography (CT)-defined emphysema is considered a predictor of lung cancer risk, it is not fully clear whether CT-defined emphysema is associated with the prognosis of lung cancer. We aimed to assess the clinical impact of CT-
Yixiao Zhang, Jiawen Yi, Dan Sun, Yanping Su, Yingting Zuo, Min Zhu, Shu Zhang, Kewu Huang, Xiaojuan Guo, Yuhui Zhang   +9 more
doaj   +1 more source

Functional Pulmonary Imaging

Journal of Magnetic Resonance Imaging, EarlyView.
ABSTRACT The aging of the world population gave rise to an increased prevalence of many lung diseases, with chronic obstructive pulmonary disease now ranking as the third‐leading cause of death according to the World Health Organization. To diagnose lung disease, a thorough assessment of lung function is essential since it may reveal unique signatures ...
Agilo L. Kern, Filip Klimeš, Andreas Voskrebenzev, Hoen‐Oh Shin, Jens Vogel‐Claussen   +4 more
wiley   +1 more source

Three new Alpha1-Antitrypsin deficiency variants help to define a C-Terminal region regulating conformational change and polymerization [PDF]

, 2012
Alpha1-antitrypsin (AAT) deficiency is a hereditary disorder associated with reduced AAT plasma levels, predisposing adults to pulmonary emphysema.
Benini, F., Corda, L., Ferrarotti, I., Fra, A.M., Gasset, M., Gooptu, Bibek, Luisetti, M., Medicina, D., Miranda, E., Ronzoni, R., Scabini, R., Schiaffonati, L.   +11 more
core   +7 more sources

Basophils trigger emphysema development in a murine model of COPD through IL-4–mediated generation of MMP-12–producing macrophages

Proceedings of the National Academy of Sciences of the United States of America, 2018
Significance Chronic obstructive pulmonary disease has generally been considered a non-Th2-type lung disease, in contrast to allergic asthma. We identified unexpected roles for basophils, Th2 cytokine IL-4, and interstitial macrophages in triggering ...
S. Shibata, K. Miyake, T. Tateishi, S. Yoshikawa, Y. Yamanishi, Y. Miyazaki, N. Inase, H. Karasuyama   +7 more
semanticscholar   +1 more source

MRI of the lung (3/3)-current applications and future perspectives [PDF]

, 2011
BACKGROUND: MRI of the lung is recommended in a number of clinical indications. Having a non-radiation alternative is particularly attractive in children and young subjects, or pregnant women.
A Hebestreit, A Kluge, A Kluge, A Kluge, AA Bankier, AC Henderson, AS Brody, BJ Pichler, BJ Pichler, C Fink, C Hintze, C Hintze, C Rieger, CA Yi, CA Yi, CP Heussel, DM Mannino, F Molinari, F Risse, F Santamaria, G Antoch, G Antoch, G Bauman, G Bauman, G Lutterbey, G Lutterbey, G Sergiacomi, H Hatabu, H Zaidi, HF Wehrl, HK Song, HK Song, IL Theissen, J Biederer, J Biederer, J Biederer, J Biederer, J Biederer, J Biederer, J Biederer, J Ley-Zaporozhan, J Ley-Zaporozhan, JC Hogg, K Cederlund, K Sandek, K Suga, K Suga, LP Qi, M Bhalla, M Decramer, M Eichinger, M Gaeta, M Oudkerk, M Puderbach, M Puderbach, M Puderbach, M Puderbach, M Stern, M Wagner, MD Cohen, ND Abolmaali, NJ Morrison, NL Müller, O Ratib, PA Jong de, PA Jong de, PD Stein, PD Stein, R Eibel, R Failo, RE Jacob, RG McFadden, RJ Theilmann, RL Gibson, S Akata, S Montella, S Pauls, SK Alford, T Amundsen, T Iwasawa, T Iwasawa, T Iwasawa, T Mori, T Rupprecht, TA Kuder, TH Helbich, US Euler, V Peltola, W Hirsch, W Lin, Y Berthezène, Y Ohba, Y Ohno, Y Ohno, Y Ohno, Y Ohno, Y Shao   +96 more
core   +1 more source

Effect and Mechanism of Running on Mouse Emphysema Model Induced by Cigarette Extract

康复学报, 2022
ObjectiveTo observe the effect of running on mouse emphysema model induced by cigarette extract, and to explore its mechanism based on signal transducer and activator of transcription 3 (STAT3).MethodsA total of 40 male C57BL/6 mice were randomly divided
LI Yongrong, XIE Haibin, LI hong, SUN Jie   +3 more
doaj  

Magnetic Resonance Imaging in the Clinical Evaluation of Lung Disorders: Current Status and Future Prospects

Journal of Magnetic Resonance Imaging, EarlyView.
ABSTRACT The low proton density and high signal decay rate of pulmonary tissue have previously hampered the application of magnetic resonance imaging (MRI) in the clinical evaluation of lung disorders. With the continuing technical advances in scanners, coils, pulse sequences, and image postprocessing, pulmonary MRI can provide structural and ...
Linyu Wu, Chen Gao, Ting Wu, Ning Kong, Ziwei Zhang, Jie Li, Li Fan, Maosheng Xu   +7 more
wiley   +1 more source

Roles of mitochondrial ROS and NLRP3 inflammasome in multiple ozone-induced lung inflammation and emphysema

Respiratory Research, 2018
BackgroundMitochondrial damage leading to oxidant stress may play an important role in the pathogenesis of airflow obstruction and emphysema. NLPR3 inflammasome can be activated by mitochondrial ROS (mtROS) and other stimuli.
Feng Li, Mengmeng Xu, Muyun Wang, Lei Wang, Han-Yue Wang, Hai Zhang, Yuqing Chen, J. Gong, J. Zhang, I. Adcock, K. Chung, Xin Zhou   +11 more
semanticscholar   +1 more source

Lung volumes identify an at-risk group in persons with prolonged secondhand tobacco smoke exposure but without overt airflow obstruction. [PDF]

, 2018
IntroductionExposure to secondhand smoke (SHS) is associated with occult obstructive lung disease as evident by abnormal airflow indices representing small airway disease despite having preserved spirometry (normal forced expiratory volume in 1 s-to ...
Arjomandi, Mehrdad, Blanc, Paul D, Bos, Bruce, Elicker, Brett, Geerts, Jeroen, Gold, Warren M, Keene, Jason, Stiner, Rachel K, van Koeverden, Ian, Zeng, Siyang   +9 more
core   +2 more sources

Pulmonary Emphysema Regional Distribution and Extent Assessed by Chest Computed Tomography Is Associated With Pulmonary Function Impairment in Patients With COPD

Frontiers in Medicine, 2021
Objective: This study aimed to evaluate how emphysema extent and its regional distribution quantified by chest CT are associated with clinical and functional severity in patients with chronic obstructive pulmonary disease (COPD).Methods/Design: Patients ...
Plácido Gomes, Hélder Novais e Bastos, Hélder Novais e Bastos, Hélder Novais e Bastos, Hélder Novais e Bastos, André Carvalho, André Carvalho, André Lobo, Alan Guimarães, Rosana Souza Rodrigues, Rosana Souza Rodrigues, Walter Araujo Zin, Alysson Roncally S. Carvalho, Alysson Roncally S. Carvalho, Alysson Roncally S. Carvalho, Alysson Roncally S. Carvalho   +15 more
doaj   +1 more source