Results 111 to 120 of about 334,116 (311)

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

Pengaruh Gaya Kepemimpinan Demokratis Terhadap Disiplin Kerja Karyawan PT. Mega Duta Sejahtera Cabang Palembang [PDF]

, 2018
This research aimed to examine the influence between style of democratic leadership against discipline of employee at PT. Mega Sejahtera Palembang Branch. The sample of this research were 31 respondents.
William, Yulius
core  

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Pengaruh Kemampuan Kerja,disiplin Kerja, Motivasi Kerja Terhadap Kepuasan Kerja Dan Kinerja Karyawan Administrasi Universitas Warmadewa [PDF]

, 2016
Human resource is the executor of the various activities in an organization and have a very large role for the development of the organization. Employees of the University Warmadewa Denpasar guided to always be able to improve the performance, purpose of
sekartini, N. L. (ni)
core  

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

KEPUASAN KERJA SEBAGAI VARIABEL INTERVENING UNTUK MOTIVASI, DISIPLIN, DAN SISTEM INFORMASI AKUNTANSI TERHADAP KINERJA KARYAWAN

Journal of Management Small and Medium Enterprises (SME's)
This study aims to explore the impact of motivation, discipline, and accounting information systems on employee performance, with job satisfaction serving as a mediating factor.
Nadea Fitriani, Mahameru Rosy Rochmatullah   +1 more
doaj   +1 more source

Pengaruh Budaya Organisasi Dan Disiplin Kerja Terhadap Kinerja Karyawan (Studi Kasus Pada Karyawan Bagian Produksi PT. Nyonya Meneer Semarang) [PDF]

, 2015
Employee performance can determine the success of a company. Several factors influencing employee performance are organizational cuture and work discipline. PT. Nyonya Meneer Semarang is a company which engaged in traditional medicine industry.
Agustin, E. A. (Estetika), Hadi, S. P. (Sudharto), Widiartanto, W. (Widiartanto)   +2 more
core  

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

The Role of Performance-Based Allowances, Work Motivation, and Work Discipline on Employee Performance

Almana: Jurnal Manajemen dan Bisnis
Performance Allowances, Work Motivation, and Work Discipline are essential in improving employee performance. They improve employee abilities and commitment to tasks and affect employee performance.
Nji Raden Laila Mahmudah, Sri Astuti Pratminingsih   +1 more
doaj   +1 more source