Results 141 to 150 of about 1,082,560 (364)

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

open access: yesMolecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir   +12 more
wiley   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

open access: yesMolecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He   +8 more
wiley   +1 more source

The Influence of the Physical Work Environment and Work Discipline on Employee Performance at the Tegal District Health Office

open access: yesIndonesian Interdisciplinary Journal of Sharia Economics
The Tegal District Health Service is responsible for health matters but experiences yearly fluctuations in employee performance. This research aims to evaluate the condition of the physical work environment, work discipline, and employee performance and
Malviana Febriyani, Ratna Komala Putri
doaj   +1 more source

Pengaruh Motivasi, Kompensasi Dan Jenjang Karier Yang Tersedia Terhadap Kinerja Karyawan [PDF]

open access: yes, 2012
This purpose of this research is to understand the influence of motivation, compensation, and availability of career ladder to employee performance. This research also gives a description of similar researches especially research that also related ...
., Melisa
core  

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

open access: yesMolecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia   +9 more
wiley   +1 more source

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