Results 131 to 140 of about 8,776,584 (297)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

THE EFFECT OF COMPENSATION, EMPLOYEE MOTIVATION, AND CHANGE MANAGEMENT ON EMPLOYEE PERFORMANCE AT PAM TIRTA MANGKALUKU PALOPO CITY

Journal of Management Small and Medium Enterprises (SME's)
This research investigates how compensation, employee motivation, and change management impact employee performance at PAM Tirta Mangkaluku in Palopo City. The research utilizes a quantitative approach.
Amalia Amalia, Edi Maszudi, Adil Adil
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Digital Leadership's Influence on Individual Creativity and Employee Performance: A View through the Generational Lens. [PDF]

Behav Sci (Basel), 2023
Öngel V, Günsel A, Gençer Çelik G, Altındağ E, Tatlı HS.   +4 more
europepmc   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

The impact of Performance Appraisal on Employee Performance: The Mediating Role of Employee Motivation

One of the significant aspects in the success of organizations is the performance of employees, and this is particularly in developing economies such as Pakistan where the formal HR practices are yet to take a formal approach. The research reviewed the relationship between Performance Appraisal (PA) and Employee Performance (EP) and a mediating ...
Dr. Omar Ahmed Shaikh, Shayan Munir
openaire   +2 more sources

Employee Performance Reviewed By The Perspective Of Employee Appreciation

International Journal Of Humanities Education and Social Sciences (IJHESS)
This study aims to analyze employee performance in terms of compensation variables and career development in PDAM Tirta Giri Cirebon. This type of research uses a multiple regression analysis. 58 respondents were given questionnaires as part of the research methodology, which employed quantitative techniques and primary data.
Zahroh Zahroh, Fikri Rido Junianto, Jinan Tibrani Baariq   +2 more
openaire   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

The Influence of the Physical Work Environment and Work Discipline on Employee Performance at the Tegal District Health Office

Indonesian Interdisciplinary Journal of Sharia Economics
The Tegal District Health Service is responsible for health matters but experiences yearly fluctuations in employee performance. This research aims to evaluate the condition of the physical work environment, work discipline, and employee performance and
Malviana Febriyani, Ratna Komala Putri
doaj   +1 more source