Results 111 to 120 of about 8,776,584 (297)

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

open access: yesFEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Do Workers Gain by Sharing? Employee Outcomes under Employee Ownership, Profit Sharing, and Broad-based Stock Options [PDF]

open access: yes
This paper examines how shared capitalism compensation systems - those that link employee pay to company performance - affect diverse employee outcomes.
Joseph Blasi   +2 more
core  

Top management green commitment and employee in-role green performance: An emerging economy study

open access: yesSustainable Futures
This study examines how and when top management green commitment influences in-role employee green performance, by investigating the mediating role of employee green passion and employee green commitment, and the moderating role of adverse working ...
Hung Trong Hoang   +4 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

open access: yesMolecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla   +9 more
wiley   +1 more source

Employee Ownership, Board Representation, and Corporate Financial Policies. [PDF]

open access: yes
French law mandates that employees of large publicly listed companies be allowed to elect two types of directors to represent employees. First, partially privatized companies must reserve two or three (depending on board size) board seats for directors ...
Megginson, William   +2 more
core   +2 more sources

Psychological Meaningfulness and Contextual Performance: Mediation Role of Employee Engagement

open access: yesJurisma: Jurnal Riset Bisnis & Manajemen
Research has increasingly focused on psychological factors that enhance employee engagement and improve outcomes. While prior studies have shown a positive link between psychological meaningfulness and contextual performance, the mediating role of ...
Samuel Kwesi Cudjor   +2 more
doaj   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

open access: yesMolecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera   +11 more
wiley   +1 more source

High Performance Work Practices and Employee Voice: A Comparison of Japanese and Korean Workers [PDF]

open access: yes
Using a unique new cross-national survey of Japanese and Korean workers, we report the first systematic evidence on the effects on employee voice of High Performance Work Practices (HPWPs) from the two economies which are noted for the wide use of HPWPs.
Chuma, Hiroyuki   +4 more
core  

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

open access: yesMolecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner   +14 more
wiley   +1 more source

Linking behavioral control to frontline employee commitment and performance: a test of two alternative explanations using motivation theories [PDF]

open access: yes, 2006
We propose and empirically test a model in which behavioral control is linked to frontline employee commitment and performance. We test two alternative explanations by examining the intermediate role of job autonomy and situational learning orientation ...
Dewettinck, Koen, Buyens, Dirk
core  

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