Results 91 to 100 of about 950,753 (317)
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
, 2012 The Employee Demand study (UKCES, 2009) highlighted the significant barriers to learning that are faced by a number of UK employees. This report sets out the findings of a study into the motivators and barriers to participation in workplace learning by ...
Egdell, Valerie +4 more
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Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Diagnostic accuracy of daytime polysomnography: a reappraisal during the COVID-19 era
Monaldi Archives for Chest DiseaseLevel I conventional polysomnography (PSG), the gold standard for diagnosing obstructive sleep apnea (OSA), requires an overnight stay. This study evaluated the role of daytime PSG as an alternative diagnostic tool.
Mahismita Patro +4 more
doaj +1 more source
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Federal employees peace referendum ballot
, 2017 The Federal Employees Peace Referendum was created and circulated to federal employees by Federal Employees for Peace in 1971 asking whether they "support an immediate and total cessation of all bombing, and the withdrawal of all American land, sea, and
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Diagnostic accuracy and utility of The Bethesda System for Reporting Thyroid Cytopathology (TBSRTC), 2017 in an Indian Scenario: A tertiary care appraisal [PDF]
Al Ameen Journal of Medical SciencesObjective: To categorize the cytological pattern according to Bethesda System for Reporting Thyroid Cytopathology and correlate them with the histopathological diagnosis.
Sujata Raychaudhuri +5 more
doaj
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Other title: Retirement Planning and the Regulations Affecting Benefits
, 2009 application/pdfA set of 12 documents provided by the Kansas Public Employees Retirement System with resources and information on Retirement Planning and the Regulations Affecting Benefits.Investment Expertise: Keenly Dedicated to Growing Assets for ...
Kansas Public Employees Retirement System.
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Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source